Zobrazeno 1 - 10
of 198
pro vyhledávání: '"Robert N. Pike"'
Autor:
Xiaojun Yuan, Matthew D. Johnson, Jing Zhang, Alvin W. Lo, Mark A. Schembri, Lakshmi C. Wijeyewickrema, Robert N. Pike, Gerard H. M. Huysmans, Ian R. Henderson, Denisse L. Leyton
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Autotransporter passenger domains are presented on or released from the bacterial surface upon translocation through an outer membrane β-barrel anchor. Here the authors study the two E. coli autotransporters Pet and EspP and propose that the β-barr
Externí odkaz:
https://doaj.org/article/f98a1b1242774a1e9a6565cc46622c09
Autor:
Ruby H.P. Law, Tom Caradoc-Davies, Nathan Cowieson, Anita J. Horvath, Adam J. Quek, Joanna Amarante Encarnacao, David Steer, Angus Cowan, Qingwei Zhang, Bernadine G.C. Lu, Robert N. Pike, A. Ian Smith, Paul B. Coughlin, James C. Whisstock
Publikováno v:
Cell Reports, Vol 1, Iss 3, Pp 185-190 (2012)
Plasminogen is the proenzyme precursor of the primary fibrinolytic protease plasmin. Circulating plasminogen, which comprises a Pan-apple (PAp) domain, five kringle domains (KR1-5), and a serine protease (SP) domain, adopts a closed, activation-resis
Externí odkaz:
https://doaj.org/article/2c62663f2bb6490196cafd3ad423cc3a
Autor:
Nidhish Francis, Reza Sanaei, Babatunde A. Ayodele, Neil M. O'Brien‐Simpson, David P. Fairlie, Lakshmi C. Wijeyewickrema, Robert N. Pike, Eleanor Jean Mackie, Charles Neil Pagel
Publikováno v:
Journal of Periodontal Research. 58:544-552
Autor:
Rhys Grinter, Pok Man Leung, Lakshmi C Wijeyewickrema, Dene Littler, Simone Beckham, Robert N Pike, Daniel Walker, Chris Greening, Trevor Lithgow
Publikováno v:
PLoS Genetics, Vol 15, Iss 10, p e1008435 (2019)
Bacteria have evolved sophisticated uptake machineries in order to obtain the nutrients required for growth. Gram-negative plant pathogens of the genus Pectobacterium obtain iron from the protein ferredoxin, which is produced by their plant hosts. Th
Externí odkaz:
https://doaj.org/article/368c0a8a4298484d89ac2283aa82291b
Autor:
Tang Yongqing, Jing Pan, Tracey J. Brown, Robert N. Pike, Pascal G. Wilmann, Tracey Mynott, Lakshmi C. Wijeyewickrema, Michael L. West
Publikováno v:
Biochimie. 166:194-202
Ananain (EC 3.4.22.31) accounts for less than 10% of the total enzyme in the crude pineapple stem extract known as bromelain, yet yields the majority of the proteolytic activity of bromelain. Despite a high degree of sequence identity between ananain
Autor:
Angela Mika, Simone L Reynolds, Frida C Mohlin, Charlene Willis, Pearl M Swe, Darren A Pickering, Vanja Halilovic, Lakshmi C Wijeyewickrema, Robert N Pike, Anna M Blom, David J Kemp, Katja Fischer
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40489 (2012)
Scabies is a parasitic infestation of the skin by the mite Sarcoptes scabiei that causes significant morbidity worldwide, in particular within socially disadvantaged populations. In order to identify mechanisms that enable the scabies mite to evade h
Externí odkaz:
https://doaj.org/article/febdc3f5832d46f69ef210d1b47c34a3
Publikováno v:
Molecular immunology. 126
The serpin, C1-inhibitor (also known as SERPING1), plays a vital anti-inflammatory role in the body by controlling pro-inflammatory pathways such as complement and coagulation. The inhibitor's action is enhanced in the presence of polyanionic cofacto
Autor:
Roger J. Daly, Jerico Revote, Tatiana T. Marquez-Lago, Geoffrey I. Webb, Jiangning Song, James C. Whisstock, A. Ian Smith, Gholamreza Haffari, André Leier, Yanan Wang, Kuo-Chen Chou, Robert N. Pike, Chen Li, Neil D. Rawlings, Fuyi Li, Tatsuya Akutsu, Anthony W. Purcell, Trevor Lithgow
Publikováno v:
Briefings in Bioinformatics. 20:2150-2166
The roles of proteolytic cleavage have been intensively investigated and discussed during the past two decades. This irreversible chemical process has been frequently reported to influence a number of crucial biological processes (BPs), such as cell
Autor:
Robert N. Pike, Eleanor J. Mackie, Charles N. Pagel, Babatunde A. Ayodele, Nidhish Francis, Alison L. Every
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 92:95-103
Activation of protease-activated receptor-2 (PAR2) expressed by T cells has been linked to the bone loss associated with periodontitis. We generated PAR2 conditional-null mice and crossed these with mice expressing Cre recombinase under control of th
Autor:
Poh Chee Ong, Sarah J Golding, Mary C Pearce, James A Irving, Sergei A Grigoryev, Debbie Pike, Christopher G Langendorf, Tanya A Bashtannyk-Puhalovich, Stephen P Bottomley, James C Whisstock, Robert N Pike, Sheena McGowan
Publikováno v:
PLoS ONE, Vol 4, Iss 3, p e4727 (2009)
Chromatin condensation to heterochromatin is a mechanism essential for widespread suppression of gene transcription, and the means by which a chromatin-associated protein, MENT, induces a terminally differentiated state in cells. MENT, a protease inh
Externí odkaz:
https://doaj.org/article/8b3084587a85488b8314866eeae7b760