Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Robert N Kirchdoerfer"'
Autor:
Mona Seifert, Subhas C Bera, Pauline van Nies, Robert N Kirchdoerfer, Ashleigh Shannon, Thi-Tuyet-Nhung Le, Xiangzhi Meng, Hongjie Xia, James M Wood, Lawrence D Harris, Flavia S Papini, Jamie J Arnold, Steven Almo, Tyler L Grove, Pei-Yong Shi, Yan Xiang, Bruno Canard, Martin Depken, Craig E Cameron, David Dulin
Publikováno v:
eLife, Vol 10 (2021)
The absence of ‘shovel-ready’ anti-coronavirus drugs during vaccine development has exceedingly worsened the SARS-CoV-2 pandemic. Furthermore, new vaccine-resistant variants and coronavirus outbreaks may occur in the near future, and we must be r
Externí odkaz:
https://doaj.org/article/3f924b912930433ba8d5da28b1275015
Publikováno v:
PLoS Pathogens, Vol 12, Iss 10, p e1005937 (2016)
Filoviruses are capable of causing deadly hemorrhagic fevers. All nonsegmented negative-sense RNA-virus nucleocapsids are composed of a nucleoprotein (NP), a phosphoprotein (VP35) and a polymerase (L). However, the VP30 RNA-synthesis co-factor is uni
Externí odkaz:
https://doaj.org/article/adf6cdfcf9fe4970a96376943322f807
Autor:
Nadide Altincekic, Sophie Marianne Korn, Nusrat Shahin Qureshi, Marie Dujardin, Martí Ninot-Pedrosa, Rupert Abele, Marie Jose Abi Saad, Caterina Alfano, Fabio C. L. Almeida, Islam Alshamleh, Gisele Cardoso de Amorim, Thomas K. Anderson, Cristiane D. Anobom, Chelsea Anorma, Jasleen Kaur Bains, Adriaan Bax, Martin Blackledge, Julius Blechar, Anja Böckmann, Louis Brigandat, Anna Bula, Matthias Bütikofer, Aldo R. Camacho-Zarco, Teresa Carlomagno, Icaro Putinhon Caruso, Betül Ceylan, Apirat Chaikuad, Feixia Chu, Laura Cole, Marquise G. Crosby, Vanessa de Jesus, Karthikeyan Dhamotharan, Isabella C. Felli, Jan Ferner, Yanick Fleischmann, Marie-Laure Fogeron, Nikolaos K. Fourkiotis, Christin Fuks, Boris Fürtig, Angelo Gallo, Santosh L. Gande, Juan Atilio Gerez, Dhiman Ghosh, Francisco Gomes-Neto, Oksana Gorbatyuk, Serafima Guseva, Carolin Hacker, Sabine Häfner, Bing Hao, Bruno Hargittay, K. Henzler-Wildman, Jeffrey C. Hoch, Katharina F. Hohmann, Marie T. Hutchison, Kristaps Jaudzems, Katarina Jović, Janina Kaderli, Gints Kalniņš, Iveta Kaņepe, Robert N. Kirchdoerfer, John Kirkpatrick, Stefan Knapp, Robin Krishnathas, Felicitas Kutz, Susanne zur Lage, Roderick Lambertz, Andras Lang, Douglas Laurents, Lauriane Lecoq, Verena Linhard, Frank Löhr, Anas Malki, Luiza Mamigonian Bessa, Rachel W. Martin, Tobias Matzel, Damien Maurin, Seth W. McNutt, Nathane Cunha Mebus-Antunes, Beat H. Meier, Nathalie Meiser, Miguel Mompeán, Elisa Monaca, Roland Montserret, Laura Mariño Perez, Celine Moser, Claudia Muhle-Goll, Thais Cristtina Neves-Martins, Xiamonin Ni, Brenna Norton-Baker, Roberta Pierattelli, Letizia Pontoriero, Yulia Pustovalova, Oliver Ohlenschläger, Julien Orts, Andrea T. Da Poian, Dennis J. Pyper, Christian Richter, Roland Riek, Chad M. Rienstra, Angus Robertson, Anderson S. Pinheiro, Raffaele Sabbatella, Nicola Salvi, Krishna Saxena, Linda Schulte, Marco Schiavina, Harald Schwalbe, Mara Silber, Marcius da Silva Almeida, Marc A. Sprague-Piercy, Georgios A. Spyroulias, Sridhar Sreeramulu, Jan-Niklas Tants, Kaspars Tārs, Felix Torres, Sabrina Töws, Miguel Á. Treviño, Sven Trucks, Aikaterini C. Tsika, Krisztina Varga, Ying Wang, Marco E. Weber, Julia E. Weigand, Christoph Wiedemann, Julia Wirmer-Bartoschek, Maria Alexandra Wirtz Martin, Johannes Zehnder, Martin Hengesbach, Andreas Schlundt
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
The highly infectious disease COVID-19 caused by the Betacoronavirus SARS-CoV-2 poses a severe threat to humanity and demands the redirection of scientific efforts and criteria to organized research projects. The international COVID19-NMR consortium
Externí odkaz:
https://doaj.org/article/201170fa84b8450e9b468d9fb4480774
Autor:
Jingyue Ju, Xiaoxu Li, Shiv Kumar, Steffen Jockusch, Minchen Chien, Chuanjuan Tao, Irina Morozova, Sergey Kalachikov, Robert N. Kirchdoerfer, James J. Russo
Publikováno v:
Pharmacology Research & Perspectives, Vol 8, Iss 6, Pp n/a-n/a (2020)
Abstract SARS‐CoV‐2, a member of the coronavirus family, has caused a global public health emergency. Based on our analysis of hepatitis C virus and coronavirus replication, and the molecular structures and activities of viral inhibitors, we prev
Externí odkaz:
https://doaj.org/article/c4e280e62da0401999fbdd345e4fd779
Autor:
Da-Yuan Chen, Chue Vin Chin, Devin Kenney, Alexander H. Tavares, Nazimuddin Khan, Hasahn L. Conway, GuanQun Liu, Manish C. Choudhary, Hans P. Gertje, Aoife K. O’Connell, Scott Adams, Darrell N. Kotton, Alexandra Herrmann, Armin Ensser, John H. Connor, Markus Bosmann, Jonathan Z. Li, Michaela U. Gack, Susan C. Baker, Robert N. Kirchdoerfer, Yachana Kataria, Nicholas A. Crossland, Florian Douam, Mohsan Saeed
Publikováno v:
Nature. 615:143-150
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b38361413ea484128a043ed919878160
https://doi.org/10.1038/s41586-023-05697-2
https://doi.org/10.1038/s41586-023-05697-2
Publikováno v:
bioRxiv
Coronaviruses are a diverse subfamily of viruses containing pathogens of humans and animals. This subfamily of viruses replicates their RNA genomes using a core polymerase complex composed of viral non-structural proteins: nsp7, nsp8 and nsp12. Most
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55bd5bc0f053c8df166cde454f005b65
https://doi.org/10.1101/2023.03.15.532841
https://doi.org/10.1101/2023.03.15.532841
Autor:
Misha Klein, Subhas C. Bera, Thomas K. Anderson, Bing Wang, Flavia S. Papini, Jamie J. Arnold, Craig E. Cameron, Martin Depken, Robert N. Kirchdoerfer, Irina Artsimovitch, David Dulin
Publikováno v:
Biophysical Journal, 122(3 Supplement 1), 171a-171a. Biophysical Society
Klein, M, Bera, S C, Anderson, T K, Wang, B, Papini, F S, Arnold, J J, Cameron, C E, Depken, M, Kirchdoerfer, R N, Artsimovitch, I & Dulin, D 2023, ' Mechanism of assembly of an elongation-competent SARS-CoV-2 replication transcription complex ', Biophysical Journal, vol. 122, no. 3 Supplement 1, pp. 171a-171a . https://doi.org/10.1016/j.bpj.2022.11.1071
Klein, M, Bera, S C, Anderson, T K, Wang, B, Papini, F S, Arnold, J J, Cameron, C E, Depken, M, Kirchdoerfer, R N, Artsimovitch, I & Dulin, D 2023, ' Mechanism of assembly of an elongation-competent SARS-CoV-2 replication transcription complex ', Biophysical Journal, vol. 122, no. 3 Supplement 1, pp. 171a-171a . https://doi.org/10.1016/j.bpj.2022.11.1071
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fb8339eb4a500aacda2e6045c01b27b
https://research.vu.nl/en/publications/b815bc2f-c880-41dc-a5f6-3840c02196a0
https://research.vu.nl/en/publications/b815bc2f-c880-41dc-a5f6-3840c02196a0
Autor:
Rukesh Chinthapatla, Mohamad Sotoudegan, Pankaj Srivastava, Thomas K Anderson, Ibrahim M Moustafa, Kellan T Passow, Samantha A Kennelly, Ramkumar Moorthy, David Dulin, Joy Y Feng, Daniel A Harki, Robert N Kirchdoerfer, Craig E Cameron, Jamie J Arnold
Publikováno v:
Nucleic acids research.
Some of the most efficacious antiviral therapeutics are ribonucleos(t)ide analogs. The presence of a 3′-to-5′ proofreading exoribonuclease (ExoN) in coronaviruses diminishes the potency of many ribonucleotide analogs. The ability to interfere wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8fd92610460d7ec54c97c5850c8566a
https://pubmed.ncbi.nlm.nih.gov/35982684
https://pubmed.ncbi.nlm.nih.gov/35982684
Autor:
Da-Yuan Chen, Devin Kenney, Chue Vin Chin, Alexander H. Tavares, Nazimuddin Khan, Hasahn L. Conway, GuanQun Liu, Manish C. Choudhary, Hans P. Gertje, Aoife K. O’Connell, Darrell N. Kotton, Alexandra Herrmann, Armin Ensser, John H. Connor, Markus Bosmann, Jonathan Z. Li, Michaela U. Gack, Susan C. Baker, Robert N. Kirchdoerfer, Yachana Kataria, Nicholas A. Crossland, Florian Douam, Mohsan Saeed
Publikováno v:
bioRxiv
The recently identified, globally predominant SARS-CoV-2 Omicron variant (BA.1) is highly transmissible, even in fully vaccinated individuals, and causes attenuated disease compared with other major viral variants recognized to date1–7. The Omicron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3279a4a97381ecc3f70f982468c869cc
https://europepmc.org/articles/PMC9580375/
https://europepmc.org/articles/PMC9580375/
Autor:
Xiaoxu Li, Steffen Jockusch, Chuanjuan Tao, Jingyue Ju, Robert N. Kirchdoerfer, James J. Russo, Minchen Chien, Shiv Kumar, Thomas K. Anderson
Publikováno v:
Journal of Proteome Research
SARS-CoV-2 is responsible for the current COVID-19 pandemic. On the basis of our analysis of hepatitis C virus and coronavirus replication, and the molecular structures and activities of viral inhibitors, we previously demonstrated that three nucleot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0876f4c55dcdf8a60a1c738b5e30f34c
https://doi.org/10.1021/acs.jproteome.0c00392
https://doi.org/10.1021/acs.jproteome.0c00392