Zobrazeno 1 - 10
of 175
pro vyhledávání: '"Robert N Kelsh"'
Autor:
Zain Alhashem, Dylan Feldner-Busztin, Christopher Revell, Macarena Alvarez-Garcillan Portillo, Karen Camargo-Sosa, Joanna Richardson, Manuel Rocha, Anton Gauert, Tatianna Corbeaux, Martina Milanetto, Francesco Argenton, Natascia Tiso, Robert N Kelsh, Victoria E Prince, Katie Bentley, Claudia Linker
Publikováno v:
eLife, Vol 11 (2022)
Coordination of cell proliferation and migration is fundamental for life, and its dysregulation has catastrophic consequences, such as cancer. How cell cycle progression affects migration, and vice versa, remains largely unknown. We address these que
Externí odkaz:
https://doaj.org/article/46c887effd434e8e951b0000a22ed165
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0244794 (2021)
Understanding how fate specification of distinct cell-types from multipotent progenitors occurs is a fundamental question in embryology. Neural crest stem cells (NCSCs) generate extraordinarily diverse derivatives, including multiple neural, skeletog
Externí odkaz:
https://doaj.org/article/5f4cc3e0dc35441f8ae9bdc4a458fd39
Autor:
Jennifer P Owen, Robert N Kelsh
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0246504 (2021)
Zebrafish are frequently used as a means to investigate development. These studies increasingly require repeated anaesthesia of zebrafish during juvenile (i.e. metamorphic) stages. The effects of anaesthesia during this time remain poorly studied. Th
Externí odkaz:
https://doaj.org/article/d3b570868db44be4ba61f3e78839b1c7
Autor:
Sarah McCallum, Yuuki Obata, Evangelia Fourli, Stefan Boeing, Christopher J Peddie, Qiling Xu, Stuart Horswell, Robert N Kelsh, Lucy Collinson, David Wilkinson, Carmen Pin, Vassilis Pachnis, Tiffany A Heanue
Publikováno v:
eLife, Vol 9 (2020)
The presence and identity of neural progenitors in the enteric nervous system (ENS) of vertebrates is a matter of intense debate. Here, we demonstrate that the non-neuronal ENS cell compartment of teleosts shares molecular and morphological character
Externí odkaz:
https://doaj.org/article/2e57d2f002cf475ba4153d7c9abee0b6
Publikováno v:
eLife, Vol 9 (2020)
Pattern formation is a key aspect of development. Adult zebrafish exhibit a striking striped pattern generated through the self-organisation of three different chromatophores. Numerous investigations have revealed a multitude of individual cell-cell
Externí odkaz:
https://doaj.org/article/0fa2e796d77240ba9b84f496bf0aed6c
Autor:
Karen Camargo-Sosa, Sarah Colanesi, Jeanette Müller, Stefan Schulte-Merker, Derek Stemple, E Elizabeth Patton, Robert N Kelsh
Publikováno v:
PLoS Genetics, Vol 15, Iss 2, p e1007941 (2019)
Skin pigment patterns are important, being under strong selection for multiple roles including camouflage and UV protection. Pigment cells underlying these patterns form from adult pigment stem cells (APSCs). In zebrafish, APSCs derive from embryonic
Externí odkaz:
https://doaj.org/article/76994c0aecaf4371ac7e04b39e324579
Autor:
Kleio Petratou, Tatiana Subkhankulova, James A Lister, Andrea Rocco, Hartmut Schwetlick, Robert N Kelsh
Publikováno v:
PLoS Genetics, Vol 14, Iss 10, p e1007402 (2018)
Multipotent neural crest (NC) progenitors generate an astonishing array of derivatives, including neuronal, skeletal components and pigment cells (chromatophores), but the molecular mechanisms allowing balanced selection of each fate remain unknown.
Externí odkaz:
https://doaj.org/article/9bab26a42db84ffd8fa6bfd1b67cc6c9
Autor:
Yusuke Nagao, Hiroyuki Takada, Motohiro Miyadai, Tomoko Adachi, Ryoko Seki, Yasuhiro Kamei, Ikuyo Hara, Yoshihito Taniguchi, Kiyoshi Naruse, Masahiko Hibi, Robert N Kelsh, Hisashi Hashimoto
Publikováno v:
PLoS Genetics, Vol 14, Iss 4, p e1007260 (2018)
Mechanisms generating diverse cell types from multipotent progenitors are fundamental for normal development. Pigment cells are derived from multipotent neural crest cells and their diversity in teleosts provides an excellent model for studying mecha
Externí odkaz:
https://doaj.org/article/2cd91230b21f47b1ab7ffe720fbd8499
Autor:
Mariana Delfino-Machín, Romain Madelaine, Giorgia Busolin, Masataka Nikaido, Sarah Colanesi, Karen Camargo-Sosa, Edward W P Law, Stefano Toppo, Patrick Blader, Natascia Tiso, Robert N Kelsh
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0172947 (2017)
The development of functional peripheral ganglia requires a balance of specification of both neuronal and glial components. In the developing dorsal root ganglia (DRGs), these components form from partially-restricted bipotent neuroglial precursors d
Externí odkaz:
https://doaj.org/article/9b15253e64a3408f9f3daf3a9fa5bc6a
Autor:
Nivedita Awasthi Mishra, Cord Drögemüller, Vidhya Jagannathan, Irene Keller, Daniel Wüthrich, Rémy Bruggmann, Julia Beck, Ekkehard Schütz, Bertram Brenig, Steffi Demmel, Simon Moser, Heidi Signer-Hasler, Aldona Pieńkowska-Schelling, Claude Schelling, Marcos Sande, Ronald Rongen, Stefan Rieder, Robert N Kelsh, Nadia Mercader, Tosso Leeb
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0180170 (2017)
Belted cattle have a circular belt of unpigmented hair and skin around their midsection. The belt is inherited as a monogenic autosomal dominant trait. We mapped the causative variant to a 37 kb segment on bovine chromosome 3. Whole genome sequence d
Externí odkaz:
https://doaj.org/article/b982f28c34024fef8e37f9c03472f63d