Zobrazeno 1 - 10
of 213
pro vyhledávání: '"Robert N Cole"'
Autor:
Diego Iacono, Kathleen Hatch, Erin K Murphy, Jeremy Post, Robert N Cole, Daniel P Perl, Regina M Day
Publikováno v:
PLoS ONE, Vol 19, Iss 3, p e0296903 (2024)
There is a growing interest in low dose radiation (LDR) to counteract neurodegeneration. However, LDR effects on normal brain have not been completely explored yet. Recent analyses showed that LDR exposure to normal brain tissue causes expression lev
Externí odkaz:
https://doaj.org/article/0b142ca91424413784cb99fa93c2856f
Autor:
Clorissa L Washington-Hughes, Shubhrajit Roy, Herana Kamal Seneviratne, Senthilkumar S Karuppagounder, Yulemni Morel, Jace W Jones, Alex Zak, Tong Xiao, Tatiana N Boronina, Robert N Cole, Namandjé N Bumpus, Christopher J Chang, Ted M Dawson, Svetlana Lutsenko
Publikováno v:
PLoS Genetics, Vol 19, Iss 1, p e1010558 (2023)
Copper (Cu) has a multifaceted role in brain development, function, and metabolism. Two homologous Cu transporters, Atp7a (Menkes disease protein) and Atp7b (Wilson disease protein), maintain Cu homeostasis in the tissue. Atp7a mediates Cu entry into
Externí odkaz:
https://doaj.org/article/b5e860a5363242f8aa88ed079f2f21e7
Autor:
Robin A Welsh, Nianbin Song, Catherine A Foss, Tatiana Boronina, Robert N Cole, Scheherazade Sadegh-Nasseri
Publikováno v:
PLoS Biology, Vol 18, Iss 2, p e3000590 (2020)
DO (HLA-DO, in human; murine H2-O) is a highly conserved nonclassical major histocompatibility complex class II (MHC II) accessory molecule mainly expressed in the thymic medulla and B cells. Previous reports have suggested possible links between DO
Externí odkaz:
https://doaj.org/article/e5e4c2e645ad4590ad5a34c09d623322
Autor:
Sun Eun Lee, Keith P West, Robert N Cole, Kerry J Schulze, Parul Christian, Lee Shu-Fune Wu, James D Yager, John Groopman, Ingo Ruczinski
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144279 (2015)
Inflammation is a condition stemming from complex host defense and tissue repair mechanisms, often simply characterized by plasma levels of a single acute reactant. We attempted to identify candidate biomarkers of systemic inflammation within the pla
Externí odkaz:
https://doaj.org/article/6ab553ecc5a94cd7864823d190c571ca
Autor:
Maggie P Wear, Dmitry Kryndushkin, Robert O'Meally, Jason L Sonnenberg, Robert N Cole, Frank P Shewmaker
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0136362 (2015)
Intracellular protein aggregation is the hallmark of several neurodegenerative diseases. Aggregates formed by polyglutamine (polyQ)-expanded proteins, such as Huntingtin, adopt amyloid-like structures that are resistant to denaturation. We used a nov
Externí odkaz:
https://doaj.org/article/029e4d73232b4ce085d3eec50b542115
Autor:
Erin E Watkin, Nicolas Arbez, Elaine Waldron-Roby, Robert O'Meally, Tamara Ratovitski, Robert N Cole, Christopher A Ross
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88284 (2014)
Phosphorylation has been shown to have a significant impact on expanded huntingtin-mediated cellular toxicity. Several phosphorylation sites have been identified on the huntingtin (Htt) protein. To find new potential therapeutic targets for Huntingto
Externí odkaz:
https://doaj.org/article/a760bb87c312433792c9a180b917b4e7
Autor:
D Brian Foster, Ting Liu, Jasma Rucker, Robert N O'Meally, Lauren R Devine, Robert N Cole, Brian O'Rourke
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e67513 (2013)
In the heart, lysine acetylation has been implicated in processes ranging from transcriptional control of pathological remodeling, to cardioprotection arising from caloric restriction. Given the emerging importance of this post-translational modifica
Externí odkaz:
https://doaj.org/article/b0976ff5cf7e4716b08c88d6445fa41f
Autor:
Anthony Cammarato, Christian H Ahrens, Nakissa N Alayari, Ermir Qeli, Jasma Rucker, Mary C Reedy, Christian M Zmasek, Marjan Gucek, Robert N Cole, Jennifer E Van Eyk, Rolf Bodmer, Brian O'Rourke, Sanford I Bernstein, D Brian Foster
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18497 (2011)
Drosophila melanogaster is emerging as a powerful model system for the study of cardiac disease. Establishing peptide and protein maps of the Drosophila heart is central to implementation of protein network studies that will allow us to assess the ha
Externí odkaz:
https://doaj.org/article/67a4b5101a604206ab9a275296f7454e
Autor:
Rocío Montes de Oca, Christopher J Shoemaker, Marjan Gucek, Robert N Cole, Katherine L Wilson
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e7050 (2009)
Nuclear lamin filaments and associated proteins form a nucleoskeletal ("lamina") network required for transcription, replication, chromatin organization and epigenetic regulation in metazoans. Lamina defects cause human disease ("laminopathies") and
Externí odkaz:
https://doaj.org/article/bf146d6d6ea14eb4b32e2e14b585dbef
Autor:
Bronwen Martin, Randall Brenneman, Kevin G Becker, Marjan Gucek, Robert N Cole, Stuart Maudsley
Publikováno v:
PLoS ONE, Vol 3, Iss 7, p e2750 (2008)
Alzheimer's disease (AD) is characterized by progressive cognitive impairment associated with accumulation of amyloid beta-peptide, synaptic degeneration and the death of neurons in the hippocampus, and temporal, parietal and frontal lobes of the cer
Externí odkaz:
https://doaj.org/article/f77601e35d24480fb245a7547a90d2f5