Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Robert N Bone"'
Autor:
Tomader Ali, George Kokotos, Victoria Magrioti, Robert N Bone, James A Mobley, William Hancock, Sasanka Ramanadham
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71748 (2013)
Ongoing studies suggest an important role for iPLA2β in a multitude of biological processes and it has been implicated in neurodegenerative, skeletal and vascular smooth muscle disorders, bone formation, and cardiac arrhythmias. Thus, identifying an
Externí odkaz:
https://doaj.org/article/98220f483b8445c79a9c1c4be28a5dcd
Autor:
Yanqing Zhang, Yuan Zhang, Robert N Bone, Wanxing Cui, Ji-Bin Peng, Gene P Siegal, Hongjun Wang, Hongju Wu
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36675 (2012)
The non-β endocrine cells in pancreatic islets play an essential counterpart and regulatory role to the insulin-producing β-cells in the regulation of blood-glucose homeostasis. While significant progress has been made towards the understanding of
Externí odkaz:
https://doaj.org/article/e9917974b39c4006a69031247f852c58
Autor:
Farooq Syed, Divya Singhal, Koen Raedschelders, Preethi Krishnan, Robert N. Bone, Madeline R. McLaughlin, Jennifer E. Van Eyk, Raghavendra G. Mirmira, Mei-Ling Yang, Mark J. Mamula, Huanmei Wu, Xiaowen Liu, Carmella Evans-Molina
Publikováno v:
EBioMedicine, Vol 87, Iss , Pp 104379- (2023)
Summary: Background: Stress responses within the β cell have been linked with both increased β cell death and accelerated immune activation in type 1 diabetes (T1D). At present, information on the timing and scope of these responses as well as dise
Externí odkaz:
https://doaj.org/article/e4d20da624eb40df994a03c5fc5bd7ca
Autor:
Rebecca K. Davidson, Sukrati Kanojia, Wenting Wu, Tatsuyoshi Kono, Jerry Xu, Meredith Osmulski, Robert N. Bone, Nolan Casey, Carmella Evans-Molina, Emily K. Sims, Jason M. Spaeth
The transcriptional activity of Pdx1 is modulated by a diverse array of coregulatory factors that govern chromatin accessibility, histone modifications, and nucleosome distribution. We previously identified the Chd4 subunit of the nucleosome remodeli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a03ae668fe75f1bb64d63f350f20ed1
https://doi.org/10.2337/figshare.22236679
https://doi.org/10.2337/figshare.22236679
Publikováno v:
Blood. 140:10958-10959
Publikováno v:
Blood. 140:13234-13235
Autor:
Hitoshi Iida, Tatsuyoshi Kono, Chih-Chun Lee, Preethi Krishnan, Matthew C. Arvin, Staci A. Weaver, Timothy S. Jarvela, Robert N. Bone, Xin Tong, Peter Arvan, Iris Lindberg, Carmella Evans-Molina
Increased circulating levels of incompletely processed insulin (i.e. proinsulin) are observed clinically in both type 1 and type 2 diabetes; however, the mechanisms underlying impaired proinsulin processing remain incompletely understood. Here, we id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4650c5d2e43900ce537422c5527ef5b1
https://doi.org/10.1101/2022.06.13.495980
https://doi.org/10.1101/2022.06.13.495980
Autor:
Farooq Syed, Huanmei Wu, Olufunmilola Oyebamiji, Carmella Evans-Molina, Robert N. Bone, Preethi Krishnan, Sayali Talware, Sharmila Selvaraj
Publikováno v:
Diabetes
The Golgi apparatus (GA) is an important site of insulin processing and granule maturation, but whether GA organelle dysfunction and GA stress are present in the diabetic β-cell has not been tested. We used an informatics-based approach to develop a
Autor:
Charanya Muralidharan, Tatsuyoshi Kono, Xin Tong, Staci A. Weaver, Robert N. Bone, Preethi Krishnan, Carmella Evans-Molina
The β cell Golgi apparatus serves as a significant store of intracellular Ca2+ and an important site of proinsulin maturation. However, the contribution of Golgi Ca2+ to diabetes pathophysiology is unknown. The Golgi primarily utilizes the Secretory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd978efd22c8ed8f5f94d1e7de5b7a6e
https://doi.org/10.1101/2021.08.30.458203
https://doi.org/10.1101/2021.08.30.458203
Publikováno v:
Diabetes. 70
Diabetes is a common complication among persons with cystic fibrosis (CF), affecting nearly 20% of adolescents and 50% of all adults with CF. The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) knockout (KO) ferret is a well-characterized