Zobrazeno 1 - 10
of 423
pro vyhledávání: '"Robert N Baldassano"'
Autor:
Máire A. Conrad, Kyle Bittinger, Yue Ren, Kelly Kachelries, Jennifer Vales, Hongzhe Li, Gary D. Wu, Frederic D. Bushman, Marcella Devoto, Robert N Baldassano, Judith R. Kelsen
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
ABSTRACTDysbiosis is associated with pediatric and adult-onset inflammatory bowel disease (IBD), but the role of dysbiosis and the microbiome in very early onset IBD (VEO-IBD) has not yet been described. Here, we aimed to demonstrate the impact of ag
Externí odkaz:
https://doaj.org/article/75bceb6e38a04628a5628960e23be4f7
Autor:
Wenjing Zong, Amit Patel, Vivian Chang, Elana B Mitchel, Natalie Stoner, Robert N Baldassano, Lindsey Albenberg
Publikováno v:
PLoS ONE, Vol 18, Iss 3, p e0281949 (2023)
BackgroundWhile there are many epidemiologic studies of Asian immigrants to the West and risk of inflammatory bowel disease (IBD), the phenotype and lifestyle of Asian patients, particularly children, with IBD are not well described. In this study, w
Externí odkaz:
https://doaj.org/article/a35f377969824e1c8dc2ba3f9897586d
Autor:
Alexander S F Berry, Brendan J Kelly, Denise Barnhart, Donna J Kelly, Daniel P Beiting, Robert N Baldassano, Laurel E Redding
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0215497 (2019)
In people, colonization with Clostridioides difficile, the leading cause of antibiotic-associated diarrhea, has been shown to be associated with distinct gut microbial features, including reduced bacterial community diversity and depletion of key tax
Externí odkaz:
https://doaj.org/article/80ef98a8a0a64ca1aca22c5a3fcc8293
Autor:
Christopher J Cardinale, Zhi Wei, Jin Li, Junfei Zhu, Mengnan Gu, Robert N Baldassano, Struan F A Grant, Hakon Hakonarson
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96153 (2014)
Human colonic mucosa altered by inflammation due to ulcerative colitis (UC) displays a drastically altered pattern of gene expression compared with healthy tissue. We aimed to understand the underlying molecular pathways influencing these differences
Externí odkaz:
https://doaj.org/article/ddb9ef70a4464adf90e1c26a8a20ee96
Autor:
Kathryn Clarkston, Rebekah Karns, Anil G Jegga, Mihika Sharma, Sejal Fox, Babajide A Ojo, Phillip Minar, Thomas D Walters, Anne M Griffiths, David R Mack, Brendan Boyle, Neal S LeLeiko, James Markowitz, Joel R Rosh, Ashish S Patel, Sapana Shah, Robert N Baldassano, Marian Pfefferkorn, Cary Sauer, Subra Kugathasan, Yael Haberman, Jeffrey S Hyams, Lee A Denson, Michael J Rosen
Publikováno v:
J Crohns Colitis
Background and AimsWe aimed to determine whether a targeted gene expression panel could predict clinical outcomes in paediatric ulcerative colitis [UC] and investigated putative pathogenic roles of predictive genes.MethodsIn total, 313 rectal RNA sam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22599f11cd62c1ce64aa7c303dab9246
https://pubmed.ncbi.nlm.nih.gov/35665804
https://pubmed.ncbi.nlm.nih.gov/35665804
Autor:
Ronen, Stein, Scott G, Daniel, Robert N, Baldassano, Kara, Feigenbaum, Kelly, Kachelries, Rotem, Sigall-Boneh, Sarah, Weston, Arie, Levine, Kyle, Bittinger
Publikováno v:
Journal of Pediatric Gastroenterology & Nutrition. 75:608-615
The primary aim of this study was to determine the proportion of pediatric Crohn disease (CD) subjects in sustained drug-free remission 52 weeks after stopping pharmacological therapy. We also aimed to explore the effects of the Crohn Disease Exclusi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72498e1efe6386186e437f1b65352be2
https://doi.org/10.1097/mpg.0000000000003589
https://doi.org/10.1097/mpg.0000000000003589
Autor:
Yizhao Zhou, Jiasheng Shi, Ronen Stein, Xiaokang Liu, Robert N Baldassano, Christopher B Forrest, Yong Chen, Jing Huang
Publikováno v:
Journal of the American Medical Informatics Association.
Objectives The impacts of missing data in comparative effectiveness research (CER) using electronic health records (EHRs) may vary depending on the type and pattern of missing data. In this study, we aimed to quantify these impacts and compare the pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f1ae46320412e7afe3da1f749345307
https://doi.org/10.1093/jamia/ocad066
https://doi.org/10.1093/jamia/ocad066
Publikováno v:
J Pediatr Gastroenterol Nutr
BACKGROUND: The objective of this study is to identify subgroups of pediatric CD who had differential responses to the infliximab treatment through trajectory cluster analysis of disease activity using data from electronic health records. METHODS: We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11a805679ee206b40462d374026a77f7
https://pubmed.ncbi.nlm.nih.gov/34908016
https://pubmed.ncbi.nlm.nih.gov/34908016
Autor:
David R. Mack, Jarod Prince, Susan S. Baker, Brendan M. Boyle, Rebekah Karns, Suresh Venkateswaran, Subra Kugathasan, Talin Haritunians, Dermot P.B. McGovern, Mamta Giri, James Markowitz, Nai Yun Hsu, Melvin B. Heyman, Lee A. Denson, Ling-Shiang Chuang, Mayte Suárez-Fariñas, Greg Gibson, Jeffrey S. Hyams, Neal S. LeLeiko, Andrew Kasarskis, Kyle Gettler, Bruce J. Aronow, Cary G. Sauer, Yael Haberman, Carmen Argmann, Anne M. Griffiths, Joel R. Rosh, Nathan Gotman, Angela Mo, Dalia Arafat, Sapana Shah, Paul A. Rufo, Thomas D. Walters, Marian Pfefferkorn, Ashish S. Patel, Sonia Davis Thomas, Judy H. Cho, Robert N. Baldassano, Emebet Mengesha, Joshua D. Noe, Sini Nagpal
Publikováno v:
Am J Hum Genet
American journal of human genetics, vol 108, iss 9
American journal of human genetics, vol 108, iss 9
Summary An important goal of clinical genomics is to be able to estimate the risk of adverse disease outcomes. Between 5% and 10% of individuals with ulcerative colitis (UC) require colectomy within 5 years of diagnosis, but polygenic risk scores (PR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::429feea2ec8be9ff6bb9b91aa2d58c90
https://doi.org/10.1016/j.ajhg.2021.07.013
https://doi.org/10.1016/j.ajhg.2021.07.013
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 1, Iss 5, Pp 462-476 (2015)
Inflammatory bowel disease (IBD) is a multifactoral disease caused by dysregulated immune responses to commensal or pathogenic microbes in the intestine, resulting in chronic intestinal inflammation. An emerging population of patients with IBD younge
Externí odkaz:
https://doaj.org/article/8c3f04287e8c4667ad286755d4b1ba92