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pro vyhledávání: '"Robert N, Sibley"'
Autor:
Uday R, Khire, Donald, Bankston, James, Barbosa, David R, Brittelli, Yolanda, Caringal, Robert, Carlson, Jacques, Dumas, Todd, Gane, Sarah L, Heald, Barbara, Hibner, Jeffrey S, Johnson, Michael E, Katz, Nancy, Kennure, Jill, Kingery-Wood, Wendy, Lee, Xiao-Gao, Liu, Timothy B, Lowinger, Ian, McAlexander, Mary-Katherine, Monahan, Reina, Natero, Joel, Renick, Bernd, Riedl, Hong, Rong, Robert N, Sibley, Roger A, Smith, Donald, Wolanin
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(3)
Bis-aryl ureas have been disclosed previously as a potent class of Raf kinase inhibitors. Modifications in the amide portion led to an improvement in aqueous solubility, an important characteristic for an oral drug. Based on this finding, we hypothes