Zobrazeno 1 - 10
of 214
pro vyhledávání: '"Robert N, Eisenman"'
Autor:
Ayumu Suzuki, Kousuke Uranishi, Masazumi Nishimoto, Yosuke Mizuno, Seiya Mizuno, Satoru Takahashi, Robert N. Eisenman, Akihiko Okuda
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Meiosis is a specialized type of cell division that occurs physiologically only in germ cells. We previously demonstrated that MYC-associated factor X (MAX) blocks the ectopic onset of meiosis in embryonic and germline stem cells in culture
Externí odkaz:
https://doaj.org/article/12ce24a12a9d4642b05b92a91f8d3572
Autor:
Huabo Wang, Jie Lu, Frances Alencastro, Alexander Roberts, Julia Fiedor, Patrick Carroll, Robert N. Eisenman, Sarangarajan Ranganathan, Michael Torbenson, Andrew W. Duncan, Edward V. Prochownik
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 6, Pp 1785-1804 (2022)
Background & Aims: The c-Myc (Myc) Basic helix-loop-helix leucine zipper (bHLH-ZIP) transcription factor is deregulated in most cancers. In association with Max, Myc controls target genes that supervise metabolism, ribosome biogenesis, translation, a
Externí odkaz:
https://doaj.org/article/f512386ec4624aa09ce95376ee392615
Autor:
Patrick A Carroll, Brian W Freie, Pei Feng Cheng, Sivakanthan Kasinathan, Haiwei Gu, Theresa Hedrich, James A Dowdle, Vivek Venkataramani, Vijay Ramani, Xiaoying Wu, Daniel Raftery, Jay Shendure, Donald E Ayer, Charles H Muller, Robert N Eisenman
Publikováno v:
PLoS Biology, Vol 19, Iss 10, p e3001085 (2021)
Male germ cell (GC) production is a metabolically driven and apoptosis-prone process. Here, we show that the glucose-sensing transcription factor (TF) MAX-Like protein X (MLX) and its binding partner MondoA are both required for male fertility in the
Externí odkaz:
https://doaj.org/article/bf77b2f3063744f99c20e43fed4301ca
Autor:
Haritha Mathsyaraja, Jonathen Catchpole, Brian Freie, Emily Eastwood, Ekaterina Babaeva, Michael Geuenich, Pei Feng Cheng, Jessica Ayers, Ming Yu, Nan Wu, Sitapriya Moorthi, Kumud R Poudel, Amanda Koehne, William Grady, A McGarry Houghton, Alice H Berger, Yuzuru Shiio, David MacPherson, Robert N Eisenman
Publikováno v:
eLife, Vol 10 (2021)
MGA, a transcription factor and member of the MYC network, is mutated or deleted in a broad spectrum of malignancies. As a critical test of a tumor suppressive role, we inactivated Mga in two mouse models of non-small cell lung cancer using a CRISPR-
Externí odkaz:
https://doaj.org/article/e444f5d17b9d4890b2bf40c9a7a0bd54
Autor:
Annie L. Hsieh, Xiangzhong Zheng, Zhifeng Yue, Zachary E. Stine, Anthony Mancuso, Seth D. Rhoades, Rebekah Brooks, Aalim M. Weljie, Robert N. Eisenman, Amita Sehgal, Chi V. Dang
Publikováno v:
Cell Reports, Vol 29, Iss 7, Pp 1778-1788.e4 (2019)
Summary: Drosophila Myc (dMyc) is highly conserved and functions as a transcription factor similar to mammalian Myc. We previously found that oncogenic Myc disrupts the molecular clock in cancer cells. Here, we demonstrate that misregulation of dMyc
Externí odkaz:
https://doaj.org/article/3ea8bfb9495d43c99059d82693f0ca54
Autor:
Alexandre Neves, Robert N. Eisenman
Publikováno v:
Biology Open, Vol 8, Iss 4 (2019)
The transcriptional mechanisms that allow neural stem cells (NSC) to balance self-renewal with differentiation are not well understood. Employing an in vivo RNAi screen we identify here NSC-TAFs, a subset of nine TATA-binding protein associated facto
Externí odkaz:
https://doaj.org/article/71cc117bd559468d9f8d446d9f835647
Autor:
Robert N. Eisenman
Publikováno v:
Genes & Development. 37:16-17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b162f1869ed89f6f442dc80d6dd2ea5a
https://doi.org/10.1101/gad.350467.123
https://doi.org/10.1101/gad.350467.123
Autor:
Xiaoying Wu, Robert N. Eisenman
Publikováno v:
Blood Cancer Discov
Summary: Although the MYC transcription factor has been consistently implicated in acute myeloid leukemia (AML), its gene targets and precise role in leukemogenesis remain unknown. In this issue of Blood Cancer Discovery, Yun and colleagues provide e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cef1593d537ae58214f4da107bb08de4
https://doi.org/10.1158/2643-3230.bcd-20-0230
https://doi.org/10.1158/2643-3230.bcd-20-0230
Autor:
Sivakanthan Kasinathan, Vivek Venkataramani, Pei Feng Cheng, Xiaoying Wu, Brian Freie, Patrick A. Carroll, Donald E. Ayer, Theresa Hedrich, Haiwei Gu, Vijay Ramani, Daniel Raftery, Charles H. Muller, Jay Shendure, James A. Dowdle, Robert N. Eisenman
Publikováno v:
PLoS Biology, Vol 19, Iss 10, p e3001085 (2021)
PLoS Biology
PLoS Biology
Male germ cell (GC) production is a metabolically driven and apoptosis-prone process. Here, we show that the glucose-sensing transcription factor (TF) MAX-Like protein X (MLX) and its binding partner MondoA are both required for male fertility in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a43f44e17f3fddaeccea7d3b179d4da
https://doaj.org/article/bf77b2f3063744f99c20e43fed4301ca
https://doaj.org/article/bf77b2f3063744f99c20e43fed4301ca
Autor:
Sarangarajan Ranganathan, Patrick A. Carroll, Edward V. Prochownik, Michael Torbenson, Frances Alencastro, Robert N. Eisenman, Julia Fiedor, Andrew W. Duncan, Alexander Roberts, Jie Lu, Huabo Wang
Background & AimsThe c-Myc (Myc) bHLH-ZIP transcription factor is deregulated in most cancers. In association with Max, Myc controls target genes that supervise metabolism, ribosome biogenesis, translation and proliferation. This “Myc Network” cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2003e6709dd5fc79df4b94c3f883d881
https://doi.org/10.1101/2021.08.05.455215
https://doi.org/10.1101/2021.08.05.455215
