Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Robert Moretti"'
Autor:
Hans Allgeier, Yves Auberson, Serge Bischoff, Robert Moretti, Markus Schmutz, Kurt Lingenhoehl
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:1099-1102
NMDA antagonists derived from 5-phosphonomethyl-1,4-dihydroquinoxaline-2,3-dione (3a) are potent anticonvulsant agents, and display strong protective effects in the electroshock-induced convulsion assay in mice. Their preference for the human NMDAR 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fecb5ad689d26f852fbaad439bd45f1
https://doi.org/10.1016/s0960-894x(02)00074-4
https://doi.org/10.1016/s0960-894x(02)00074-4
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:65-70
A series of 5-aminomethylquinoxaline-2,3-diones have been identified as potent and selective AMPA antagonists. Some of these compounds are also active at the glycine-binding site of the NMDA receptors. A number of these novel, water-soluble quinoxali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff70f4c1d3a2a4a48908a67ba4e2cec6
https://doi.org/10.1016/s0960-894x(97)10186-x
https://doi.org/10.1016/s0960-894x(97)10186-x
Publikováno v:
Helvetica Chimica Acta, Vol. 77, No 8 (1994) pp. 2363-2380
Alkylation of the chiral glycine derivative 2 with “activated” organohalides under ultrasound-assisted phasetransfer catalysis or with activated and nonactivated organohalides in anhydrous medium provides (mostly crystalline) alkylation products
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d03eafd98519b540350c3a7077c01d1e
https://doi.org/10.1002/hlca.19940770823
https://doi.org/10.1002/hlca.19940770823
Autor:
Robert S. Wilhelm, Jaime Rodríguez, Khisal A. Alvi, Maria Cristina Diaz, Phillip Crews, Robert Moretti, Doris L. Slate, Rita H. Lee
Publikováno v:
The Journal of Organic Chemistry. 58:4871-4880
Nine related polycyclic quinones and hydroquinones of the halenaquinone class were isolated from two Indo-Pacific collections of the sponge Xestospongia cf. carbonaria. The halenaquinone family appears not to be of polyketide origin but can be biogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b44f50318d61c956868945c4d39f02b
https://doi.org/10.1021/jo00070a023
https://doi.org/10.1021/jo00070a023
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90dc99df26b13316a8ddea4277ea97d8
https://doi.org/10.1002/chin.199818180
https://doi.org/10.1002/chin.199818180
Autor:
Siem Jacob Veenstra, Robert Moretti, Yves Auberson, Serge Bischoff, Markus Schmutz, Pierre Acklin, Silvio Ofner
Publikováno v:
ChemInform. 30
N-Substituted 5-aminomethylquinoxalinediones containing carboxy or phosphonic acids yield potent and selective AMPA and/or NMDA (glycine-binding site) antagonists. Phosphonic acid derivatives are particularly water-soluble and display potent anticonv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::035b6543bcee9adf1f022e68d01fd1d2
https://doi.org/10.1002/chin.199920133
https://doi.org/10.1002/chin.199920133
Autor:
Robert Moretti, Markus Schmutz, Kurt Lingenhoehl, Yves Auberson, Serge Bischoff, Hans Allgeier
Publikováno v:
ChemInform. 33
NMDA antagonists derived from 5-phosphonomethyl-1,4-dihydroquinoxaline-2,3-dione (3a) are potent anticonvulsant agents, and display strong protective effects in the electroshock-induced convulsion assay in mice. Their preference for the human NMDAR 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99f5d3d22192eba41b1c259604ae807a
https://doi.org/10.1002/chin.200231187
https://doi.org/10.1002/chin.200231187
Autor:
Doris L. Slate, Rita H. Lee, Maria Cristina Diaz, Khisal A. Alvi, Phillip Crews, Robert Moretti
Publikováno v:
The Journal of Organic Chemistry. 57:6604-6607
Our program to discover inhibitors of enzymes thought to be important in tumorigenesis motivated a study of marine sponge-derived sesquiterpene quinones (hydroquinones) against pp60 v-src protein tyrosine kinase (PTK). Five new metabolites were isola
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c34167ac33b65367fdfa1f1d56df8a1
https://doi.org/10.1021/jo00050a043
https://doi.org/10.1021/jo00050a043
Publikováno v:
Biochemical and Biophysical Research Communications. 184:765-772
The marine polyketide natural product, halenaquinone, was shown to be an irreversible inhibitor of pp60v-src, the oncogenic protein tyrosine kinase encoded by the Rous sarcoma virus. This compound had an IC50 of approximately 1.5 microM against pp60v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f033166c9ef4ecfab209b835d22974c5
https://doi.org/10.1016/0006-291x(92)90656-6
https://doi.org/10.1016/0006-291x(92)90656-6
Publikováno v:
American Journal of Orthodontics and Dentofacial Orthopedics. 98:77-82
Long-term (1 to 7.5 years) follow-up evaluations of 110 adult patients who were seen for diagnosis and treatment of symptoms related to myofascial problems (MP), internal derangement (ID), or both were conducted by means of telephone interview. One h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b0384ef0b6091485102a27fb845ce22
https://doi.org/10.1016/0889-5406(90)70035-b
https://doi.org/10.1016/0889-5406(90)70035-b