Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Robert Morenweiser"'
Autor:
Christian P. Sommerhoff, Milton T. Stubbs, Gerd P. Piechottka, Gabriele Matschiner, Hans Fritz, Robert Morenweiser, Wolfram Bode, Jörg Stürzebecher, Ennes A. Auerswald, Robert Huber, Margit Bauer
Publikováno v:
Journal of Biological Chemistry. 272:19931-19937
The x-ray crystal structure of recombinant leech-derived tryptase inhibitor (rLDTI) has been solved to a resolution of 1.9 A in complex with porcine trypsin. The nonclassical Kazal-type inhibitor exhibits the same overall architecture as that observe
Autor:
Bianca Habermann, Robert Morenweiser, Richard A. Engh, Peter Mühlhahn, Tad A. Holak, Christian P. Sommerhoff, Michael Czisch, Ennes A. Auerswald
Publikováno v:
FEBS Letters. 355:290-296
The three-dimensional solution structure of the leech derived tryptase inhibitor form C (LDTI-C), an inhibitor of 46 amino acids which contains 3 disulfide bridges, has been determined using 2D NMR spectroscopy. The 3D structure was determined on the
Autor:
Sebastien Folliot, Philippe Moullier, Anna Salvetti, Fabienne Rolling, Robert Morenweiser, Gabrielle Kroner-Lux, Yan Cherel, Pierre Boulanger, Estelle Toublanc, Nicole Brument, Florence Gaden, Véronique Blouin, Isabelle Raimbaud
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 6(5)
Here we describe the development of a two-step chromatography process based on the use of ion-exchange resins for the purification of recombinant adeno-associated virus (rAAV) serotypes-2 and-5. In vitro and in vivo results demonstrate that this meth
Autor:
Hans Fritz, Milton T. Stubbs, Andreas van de Locht, Ennes A. Auerswald, Robert Morenweiser, Jörg Stürzebecher
Publikováno v:
The Journal of biological chemistry. 272(32)
Using the three-dimensional structures of thrombin and the leech-derived tryptase inhibitor (LDTI), which does not inhibit thrombin, we were able to construct three LDTI variants inhibiting thrombin. Trimming of the inhibitor reactive site loop to fi
Autor:
Gerd P. Piechottka, Robert Morenweiser, Hans Fritz, Christoph Eckerskorn, Lutz G. Gürtler, Christian P. Sommerhoff, Ennes A. Auerswald
Publikováno v:
Biological chemistry Hoppe-Seyler. 375(10)
A synthetic gene coding for leech-derived tryptase inhibitor, form C (LDTI-C), was designed, cloned and expressed. The gene assembled via 6 oligonucleotides contains linker sequences, stop codons and internal restriction recognition sites for cloning