Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Robert Michelot"'
Autor:
P. Oliviero, Mariana Louis-Tisserand, Robert Michelot, Yves Lecarpentier, Juan C. Chachques, Pascal Bochet, Claudine Menard, Walid Al-Chare, Catherine Coirault, Daniel R. Salomon, Alain Carpentier, Olivier Schussler
Publikováno v:
Nature Reviews Cardiology. 6:240-249
Cardiac tissue engineering might be useful in treatment of diseased myocardium or cardiac malformations. The creation of functional, biocompatible contractile tissues, however, remains challenging. We hypothesized that coupling of arginine-glycine-as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e82bb2c7a6824f38740edb45b8f5d4b
https://doi.org/10.1038/ncpcardio1451
https://doi.org/10.1038/ncpcardio1451
Publikováno v:
International Journal of Peptide and Protein Research. 27:366-372
An optically active, alkynyl analogue of norleucine (Nle), L-2-amino-4-hexynoic acid (Aha), was substituted for Met in the solution synthesis of the Boc-protected C-terminal heptapeptide analogue of substance P. Treatment of the resulting alkynyl pep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b2b9e87d64838aabb42b7b7af86f8ef
https://doi.org/10.1111/j.1399-3011.1986.tb01029.x
https://doi.org/10.1111/j.1399-3011.1986.tb01029.x
Autor:
Michel Mayer, Marie-Thérèse Martin, Vi-Thuy Dao, Julie Hémez, Christiane Gaspard, Olivier Laprévote, Robert Michelot, Michael K. Dowd
Publikováno v:
Bioorganic & Medicinal Chemistry. 11:2001-2006
New dithiane or dithiolane derivatives of gossypol and gossypolone were synthesized with dithiolethane or dithiolpropane in the presence of BF(3)/Et(2)O. These thioderivatives exhibited low toxicity on KB cells (human epidermoid carcinoma cells of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::302d5589042079be728b8bf245a62069
https://doi.org/10.1016/s0968-0896(03)00066-x
https://doi.org/10.1016/s0968-0896(03)00066-x
The Bronchorelaxant Effect of Helicidine, a Helix Pomatia Extract, Involves Prostaglandin E2 Release
Publikováno v:
Pharmaceutical Biology. 36:13-19
Helicidine is a biological extract prepared from the snail Helix pomatia L. and used in man as an anti-tussive agent. However , its mechanisms of action are not fully defined. In this study, we have investigated a possible relaxant effect of helicidi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cc1ea73c47a58c634c888bc0749feed
https://doi.org/10.1076/phbi.36.1.13.4622
https://doi.org/10.1076/phbi.36.1.13.4622
Use of BOP-Cl in the presence of Boc-amino monothioacids for the thioacylation of iminoacid residues
Publikováno v:
Bioorganic & Medicinal Chemistry. 4:2201-2209
BOP-Cl was found to be an efficient coupling reagent for the introduction of thiopeptide bonds on imino acid residues (Pro, Sar). Boc-amino monothioacids were coupled at moderate temperature (0 degree C-RT) with fair yields and with retained optical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52fcbbcc52495beae062cea65d064ee2
https://doi.org/10.1016/s0968-0896(96)00232-5
https://doi.org/10.1016/s0968-0896(96)00232-5
Autor:
Robert Michelot, Simon Lemaire, Yanmin Chen, Vijay K. Shukla, Terry D. Cyr, Ibrahim H. Ibrahim
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 71:211-216
Dynorphin A-(1 – 13)-Tyr-Leu-Phe-Asn-Gly-Pro (Dyn Ia) was previously shown to be a highly potent and selective κ opioid peptide. Four analogs of Dyn Ia are synthesized by the solid-phase procedure, introducing pseudo CH2NH linkage between position
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2fe87159dc25796f80977cdb0d64715
https://doi.org/10.1139/y93-033
https://doi.org/10.1139/y93-033
Publikováno v:
European Journal of Medicinal Chemistry. 27:931-937
New analogues of the N-terminal fragment of substance P [Arg-Pro-Lys-Pro, SP(1–4)] were synthesized and their activities on histamine release from rat peritoneal mast cells were compared. The potency of these compounds decreases in the following or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e5e25ff7038815cfc5e1343e20c443a
https://doi.org/10.1016/0223-5234(92)90025-v
https://doi.org/10.1016/0223-5234(92)90025-v
Publikováno v:
European Journal of Medicinal Chemistry. 26:921-928
A series of pseudopeptides, analogues of neurokinin selective agonists, in which a peptide bond was replaced by a (CH2NH) bond were synthesized. The biological activities of these compounds were determined on selective pharmacological preparations: t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35dc2512fcffe3e28167c513ca7f34e0
https://doi.org/10.1016/0223-5234(91)90134-9
https://doi.org/10.1016/0223-5234(91)90134-9
Autor:
Robert Michelot, Vi-Thuy Dao, Christiane Gaspard, Marie-Thérèse Martin, Michel Mayer, Michael K. Dowd
Publikováno v:
European journal of medicinal chemistry. 39(7)
Optical Schiff’s bases of gossypol were prepared with chiral gossypol and ethylamine. As has been similarly observed among the gossypol enantiomers, the (–)-gossypol ethylimine was more active than either the (+)-gossypol ethylimine or the racemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80610c509368fbeda0ac6531d73ab7a3
https://pubmed.ncbi.nlm.nih.gov/15236842
https://pubmed.ncbi.nlm.nih.gov/15236842
Publikováno v:
International journal of peptide and protein research. 45(2)
Amino acid methyl dithioesters may be coupled in the presence of DMAP and salts to a growing peptide chain on a polymeric resin with high coupling yields and low racemization. © Munksgaard 1995.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f69b0860c5ade6dd79dda26dc5f657c7
https://pubmed.ncbi.nlm.nih.gov/7782161
https://pubmed.ncbi.nlm.nih.gov/7782161