Identifying parental and cell-division origins of aneuploidy in the human blastocyst

Autor: Bhavini Rana, Kevin Lambrese, Robert Mendola, Jia Xu, John Garrisi, Kathleen Miller, Diego Marin, Nathan R. Treff

Publikováno v: Am J Hum Genet

Preimplantation genetic testing commonly employs simplistic copy-number analyses to screen for aneuploidy in blastocyst trophectoderm biopsies. Interpreting intermediate copy number alone as evidence of mosaicism has led to suboptimal estimation of i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d60700439ffc080148952b4a461d241c
https://europepmc.org/articles/PMC10119141/

Preimplantation genetic testing for aneuploidy versus morphology as selection criteria for single frozen-thawed embryo transfer in good-prognosis patients: a multicenter randomized clinical trial

Autor: Santiago Munné, Brian Kaplan, John L. Frattarelli, Tim Child, Gary Nakhuda, F. Nicholas Shamma, Kaylen Silverberg, Tasha Kalista, Alan H. Handyside, Mandy Katz-Jaffe, Dagan Wells, Tony Gordon, Sharyn Stock-Myer, Susan Willman, Brian Acacio, Stuart Lavery, Anna Carby, Robert Boostanfar, Robert Forman, Mark Sedler, Anthea Jackson, Keith Jordan, William Schoolcraft, Susanna McReynolds, Vicki Schnell, Randall Loy, Samuel Chantilis, Lowell Ku, John Frattarelli, Arlene Morales, H. Randall Craig, Mark Perloe, Craig Witz, Wei-Hua Wang, John Wilcox, John Norian, Stephanie Marshall Thompson, Serena Chen, John Garrisi, Renee Walmsley, Robert Mendola, Samuel Pang, Denny Sakkas, Kristin Rooney, Rita Sneeringer, Michael Glassner, Leeanda Wilton, Mirjana Martic, Peter Coleman, Stephanie Shepley, Ginny Mounce, Tracey Griffiths, Ronald F. Feinberg, Keith Blauer, Brett Reggio, Rachel Rhinehart, William Ziegler, Hina Ahmed, Scott Kratka, Evan Rosenbluth, Kristen Ivani, Angela Thyer, Tamara Minter, Charles Miller, Mathias Gysler, Pauline Saunders, Robert Casper, Deirdre Conway, Mark Hughes, Michael Large, Joshua Blazek, Elpida Fragouli, Samer Alfarawati

Publikováno v: J Assist Reprod Genet

Objective To evaluate the benefit of next-generation sequencing (NGS)–based preimplantation genetic testing for aneuploidy (PGT-A) for embryo selection in frozen-thawed embryo transfer. Design Randomized controlled trial. Setting Not applicable. Pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::354c1561e5dcf72e6418215b26433d26
https://pubmed.ncbi.nlm.nih.gov/32008181