Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Robert Menard"'
Autor:
Carolina Agop-Nersesian, Bernina Naissant, Fathia Ben Rached, Manuel Rauch, Angelika Kretzschmar, Sabine Thiberge, Robert Menard, David J P Ferguson, Markus Meissner, Gordon Langsley
Publikováno v:
PLoS Pathogens, Vol 5, Iss 1, p e1000270 (2009)
The final step during cell division is the separation of daughter cells, a process that requires the coordinated delivery and assembly of new membrane to the cleavage furrow. While most eukaryotic cells replicate by binary fission, replication of api
Externí odkaz:
https://doaj.org/article/a3952266e161460fb2dc11ad031934b6
Autor:
Dieudonnée Togbe, Paulo Loureiro de Sousa, Mathilde Fauconnier, Victorine Boissay, Lizette Fick, Stefanie Scheu, Klaus Pfeffer, Robert Menard, Georges E Grau, Bich-Thuy Doan, Jean Claude Beloeil, Laurent Renia, Anna M Hansen, Helen J Ball, Nicholas H Hunt, Bernhard Ryffel, Valerie F J Quesniaux
Publikováno v:
PLoS ONE, Vol 3, Iss 7, p e2608 (2008)
BackgroundTNF-related lymphotoxin alpha (LTalpha) is essential for the development of Plasmodium berghei ANKA (PbA)-induced experimental cerebral malaria (ECM). The pathway involved has been attributed to TNFR2. Here we show a second arm of LTalpha-s
Externí odkaz:
https://doaj.org/article/03a2d237b3284307b66e4c9f4bb6006d
Autor:
William R. Roush, Robert Menard, Alejandro Alvarez-Hernandez, Hongtao Qi, Edmund Ziomek, Enrico O. Purisima, Paule Lachance, Traian Sulea, Christian Therrien
Publikováno v:
Biochemistry. 40:2702-2711
Several new cysteine proteases of the papain family have been discovered in the past few years. To help in the assignment of physiological roles and in the design of specific inhibitors, a clear picture of the specificities of these enzymes is needed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55947a5a0fa2fe89415084ab442fb529
https://doi.org/10.1021/bi002460a
https://doi.org/10.1021/bi002460a
Autor:
Jadwiga Kaleta, Ronald G. Micetich, Robert Menard, Nian E. Zhou, Enrico O. Purisima, Rajeshwar Singh
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:3417-3419
The synthesis of a new series of 6-acylamino penam derivatives and their inhibition of cysteine proteases cathepsins B, L, K, and S is described. The 6-acylamino-penam sulfone compounds showed excellent cathepsin L, K, and S inhibition activity with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1afb3dbd08af34269457f451909237c
https://doi.org/10.1016/s0960-894x(02)00766-7
https://doi.org/10.1016/s0960-894x(02)00766-7
Publikováno v:
Journal of enzyme inhibition and medicinal chemistry. 23(2)
Cathepsins have been found to have important physiological roles. The implication of cathepsin L in various types of cancers is well established. In a search for selective cathepsin L inhibitors as anticancer agents, a series of 2-cyanoprrolidine pep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7babc5ddc0b9d8bb3aeb0459c75d8e62
https://pubmed.ncbi.nlm.nih.gov/18343903
https://pubmed.ncbi.nlm.nih.gov/18343903
YdiB and its paralog AroE are members of the quinate/shikimate 5-dehdrogenase family. Enzymes from this family function in the shikimate pathway that is essential for survival of microorganisms and plants and represent potential drug targets. Recent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99c99dc8a08d2096df8f7fa92cb56431
https://doi.org/10.1074/jbc.m412028200
https://doi.org/10.1074/jbc.m412028200
Autor:
Dorit K, Nägler, Sabine, Krüger, Angela, Kellner, Edmund, Ziomek, Robert, Menard, Peter, Buhtz, Matthias, Krams, Albert, Roessner, Udo, Kellner
Publikováno v:
The Prostate. 60(2)
Evidence is accumulating that several proteases are involved in prostate cancer progression. A locus which is often amplified in prostate cancer is the chromosomal region 20q13. Interestingly, one of the genes encoding the cysteine protease cathepsin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8eea0ed72e3cef48ec537c1d4d4f730f
https://pubmed.ncbi.nlm.nih.gov/15162377
https://pubmed.ncbi.nlm.nih.gov/15162377
Autor:
Steffi Vöckler, Albert Roessner, Robert Menard, Christoph Röcken, Knut Sletten, Eike Wrenger, Silvia Bohne, Frank Bühling
Publikováno v:
The Journal of pathology. 203(1)
Cathepsin (Cath) B, CathK and CathL are cysteine proteases that participate in the lysosomal protein degradation system and are expressed in macrophages, epithelioid cells, and multinucleated histiocytic giant cells (MGCs). Both macrophages and MGCs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e72086d0e9a2f58fdcef3424a9895e71
https://pubmed.ncbi.nlm.nih.gov/15095475
https://pubmed.ncbi.nlm.nih.gov/15095475
Autor:
Robert Menard, Rajeshwar Singh, Nian E. Zhou, Jadwiga Kaleta, Ronald G. Micetich, Enrico O. Purisima, George Thomas, Deqi Guo, Andhe V. Narender Reddy
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(1)
A new class of inhibitors for cysteine proteases cathepsin B, L, K and S is described. These inhibitors are based on the β-lactam ring designed to interact with the nucleophilic thiol of the cysteine in the active site of cysteine proteases. Some 3-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf662c970730d120e0983f782b63970
https://pubmed.ncbi.nlm.nih.gov/12467634
https://pubmed.ncbi.nlm.nih.gov/12467634
Autor:
Rajeshwar Singh, Robert Menard, Nian E. Zhou, Enrico O. Purisima, Ronald G. Micetich, Jadwiga Kaleta, Deqi Guo
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(23)
A series of 6-substituted amino-4-oxa-1-azabicyclo[3,2,0]heptan-7-one compounds was designed and synthesized as a new class of inhibitors for cysteine proteases cathepsins B, L, K, and S. One compound (5 S ,6 S )-6-( N -benzyloxycarbonyl- l -phenylal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e05c01fbe19be365ea1c1e71c734ce7b
https://pubmed.ncbi.nlm.nih.gov/12419373
https://pubmed.ncbi.nlm.nih.gov/12419373