Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Robert McEwen"'
Autor:
Lillian M. Smyth, Gerald Batist, Funda Meric-Bernstam, Peter Kabos, Iben Spanggaard, Ana Lluch, Komal Jhaveri, Andrea Varga, Andrea Wong, Alison M. Schram, Helen Ambrose, T. Hedley Carr, Elza C. de Bruin, Carolina Salinas-Souza, Andrew Foxley, Joana Hauser, Justin P. O. Lindemann, Rhiannon Maudsley, Robert McEwen, Michele Moschetta, Myria Nikolaou, Gaia Schiavon, Pedram Razavi, Udai Banerji, José Baselga, David M. Hyman, Sarat Chandarlapaty
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-7 (2021)
Abstract Five to ten percent of ER+ metastatic breast cancer (MBC) tumors harbor somatic PTEN mutations. Loss of function of this tumor-suppressor gene defines a highly aggressive, treatment-refractory disease for which new therapies are urgently nee
Externí odkaz:
https://doaj.org/article/97cb292e26054c75a968bad21fc37c9b
Autor:
Norah J Shire, Alyssa B Klein, Asieh Golozar, Jenna M Collins, Kathy H Fraeman, Beth L Nordstrom, Robert McEwen, Todd Hembrough, Naiyer A Rizvi
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0238358 (2020)
BackgroundMutations in STK11 (STK11m) and frequently co-occurring KRAS mutations (KRASm/STK11m) are associated with poor survival in metastatic NSCLC (mNSCLC) immuno-oncology trials. There are limited data regarding the prognostic significance of the
Externí odkaz:
https://doaj.org/article/a5de3eaa4070440fa054983d2d067b68
Autor:
Frances M K Williams, Serena Scollen, Dandan Cao, Yasin Memari, Craig L Hyde, Baohong Zhang, Benjamin Sidders, Daniel Ziemek, Yujian Shi, Juliette Harris, Ian Harrow, Brian Dougherty, Anders Malarstig, Robert McEwen, Joel C Stephens, Ketan Patel, Cristina Menni, So-Youn Shin, Dylan Hodgkiss, Gabriela Surdulescu, Wen He, Xin Jin, Stephen B McMahon, Nicole Soranzo, Sally John, Jun Wang, Tim D Spector
Publikováno v:
PLoS Genetics, Vol 8, Iss 12, p e1003095 (2012)
Sensitivity to pain varies considerably between individuals and is known to be heritable. Increased sensitivity to experimental pain is a risk factor for developing chronic pain, a common and debilitating but poorly understood symptom. To understand
Externí odkaz:
https://doaj.org/article/f590cb1255f649c4860c3d90bb8985cb
Autor:
Marla Lipsyc-Sharf, Elza C. de Bruin, Katheryn Santos, Robert McEwen, Daniel Stetson, Ashka Patel, Gregory J. Kirkner, Melissa E. Hughes, Sara M. Tolaney, Ann H. Partridge, Ian E. Krop, Charlene Knape, Ute Feger, Giovanni Marsico, Karen Howarth, Eric P. Winer, Nancy U. Lin, Heather A. Parsons
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 40(22)
PURPOSE To examine the prevalence and dynamics of circulating tumor DNA (ctDNA) and its association with metastatic recurrence in patients with high-risk early-stage hormone receptor–positive breast cancer (HR+ BC) more than 5 years from diagnosis.
Autor:
Sabina C. Cosulich, Jason S. Carroll, Robert McEwen, Igor Chernukhin, Mandy Lawson, Azadeh Cheraghchi-Bashi, Urszula M. Polanska, Anna D. Staniszewska, Larissa S. Carnevalli, Jon O. Curwen, Oona Delpuech, Rasmus Siersbaek, Claire Crafter, Chrysiis Michaloglou
Supplementary Figure S1. Vistusertib (AZD2014) causes a decrease in RB phosphorylation in the absence of cell cycle arrest. Supplementary Figure S2. Different mTOR inhibitors in combination with palbociclib cause a decrease in cell viability. Supplem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d2971446864fbedb32439af08aab612
https://doi.org/10.1158/1535-7163.22510243
https://doi.org/10.1158/1535-7163.22510243
Autor:
Stephen Green, Francisco Cruzalegui, Lara Ward, Sabina C. Cosulich, Marie Cumberbatch, Alys Jones, Rebecca Ellston, Lyndsey Hanson, Phillippa Dudley, Oona Delpuech, Alvaro Avivar-Valderas, Pablo Morentin Gutierrez, Myria Nikolaou, Urszula M. Polanska, Robert McEwen, Cath Trigwell, Urs J. Hancox, Kevin Hudson
Tumor cell line panel composition and growth inhibition sensitivity (GI50) to AZD8835.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d4782fd316b02ec8951d691e4f7122f
https://doi.org/10.1158/1535-7163.22507675.v1
https://doi.org/10.1158/1535-7163.22507675.v1
Autor:
Stephen Green, Francisco Cruzalegui, Lara Ward, Sabina C. Cosulich, Marie Cumberbatch, Alys Jones, Rebecca Ellston, Lyndsey Hanson, Phillippa Dudley, Oona Delpuech, Alvaro Avivar-Valderas, Pablo Morentin Gutierrez, Myria Nikolaou, Urszula M. Polanska, Robert McEwen, Cath Trigwell, Urs J. Hancox, Kevin Hudson
Details on PK / PD / efficacy modeling in BT474 xenograft model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47c1af759ac8bbaffa0a90dd3c7be5a7
https://doi.org/10.1158/1535-7163.22507681
https://doi.org/10.1158/1535-7163.22507681
Autor:
Sabina C. Cosulich, Jason S. Carroll, Robert McEwen, Igor Chernukhin, Mandy Lawson, Azadeh Cheraghchi-Bashi, Urszula M. Polanska, Anna D. Staniszewska, Larissa S. Carnevalli, Jon O. Curwen, Oona Delpuech, Rasmus Siersbaek, Claire Crafter, Chrysiis Michaloglou
The cyclin dependent kinase (CDK)–retinoblastoma (RB)–E2F pathway plays a critical role in the control of cell cycle in estrogen receptor–positive (ER+) breast cancer. Small-molecule inhibitors of CDK4/6 have shown promise in this tumor type in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a430fac5fb19944258d4dc125065e6b
https://doi.org/10.1158/1535-7163.c.6539551.v1
https://doi.org/10.1158/1535-7163.c.6539551.v1
Autor:
Sabina C. Cosulich, Stephen Green, Oona Delpuech, Robert McEwen, Urszula M. Polanska, Christine M. Chresta, Martin Pass, Kurt G. Pike, Teresa Klinowska, Graham Bigley, Barry R. Davies, Zoe Howard, Michael Grondine, James W.T. Yates, Celina M. D'Cruz, Teeru Bihani, Jon Curwen, Sylvie M. Guichard
Pharmacokinetics modelling of AZD2014 intermittent dosing schedule.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aab7bc29f3860fec33ee0af943823b0
https://doi.org/10.1158/1535-7163.22505970.v1
https://doi.org/10.1158/1535-7163.22505970.v1
Autor:
Sabina C. Cosulich, Stephen Green, Oona Delpuech, Robert McEwen, Urszula M. Polanska, Christine M. Chresta, Martin Pass, Kurt G. Pike, Teresa Klinowska, Graham Bigley, Barry R. Davies, Zoe Howard, Michael Grondine, James W.T. Yates, Celina M. D'Cruz, Teeru Bihani, Jon Curwen, Sylvie M. Guichard
HCC1428-eveR and HCC1428-LTED-eveR cell lines resistant to everolimus remain sensitive to dual mTORC1/2 inhibitor AZD2014.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cbbecc1501da9a57ed9b2de4b62242f
https://doi.org/10.1158/1535-7163.22505973
https://doi.org/10.1158/1535-7163.22505973