Protocol for a phase 3, randomised, active-control study of four-factor prothrombin complex concentrate versus frozen plasma in bleeding adult cardiac surgery patients requiring coagulation factor replacement: the LEX-211 (FARES-II) trial

Autor: Éric Dumont, Lusine Abrahamyan, Stuart Mccluskey, Angela Jerath, Humara Poonawala, Andrew Stevens, Jeannie Callum, Alan Tinmouth, Daniel Wong, Gianluigi Bisleri, Tarit Saha, David Mazer, Hilary Grocott, Jane Yang, Jeff Kinney, Yoan Lamarche, Damon Scales, George Tomlinson, Fuad Moussa, Andrew Shih, Michelle Zeller, Melanie Tokessy, Keyvan Karkouti, Vivek Rao, Summer Syed, Lilia Kaustov, Sophia Wong, Lani Lieberman, Kamrouz Ghadimi, Philippe Demers, Penny Johnson, Jerrold H Levy, Justyna Bartoszko, Miki Peer, Michael Law, Michelle Wong, Mackenzie Quantz, Antoine Rochon, Fraser Rubens, Shagun Jain, Yulia Lin, Katerina Pavenski, Deep Grewal, Deborah DuMerton, Darrin Payne, Saba Ansari, Robert Mayer, Rebecca Randall, Aftab Malik, Bethany Smethurst, Laura Molnar, Angela Sirosky-Yanyk, Mark Peterson, Christopher Harle, Etienne Couture, Diem Tran, Cristina Solomon, Sigurd Knaub, Kenichi A Tanaka, Blaine Achen, Sukhpal Brar, Matthew Coley, Dana Devine, Alana Flexman, Camila Machado de Souza, Maria Rosal Martins, Terri Sun, Rob Tanzola, Mathew Yan, Raffael Zamper, Jo Carrol, Nishanthi Liyanage, Simryn Selby, Reezanoor Kabir, Shelley Oliver, Alioska Escorcia, Susana Medic, Michelle Mozel, Ramanjot Kaur, Kelly Bizovie, Sarah Buchko, Raven Arly Gonzales, Korey Sutherland, Jenna Van Roekel, Alveena Babul, Ken Tanaka, Kofi Vandyck, Amir Butt, Hisako Okada, Robert Tanzola, Reegan Tod, Aiden Scholey, Wafaa Haider, Ester Cisneros-Aguilera, Alexandre Bergeron, Genevieve Belanger, Darren Mullane, Bevan Hughes, Sakara Hutspardol, Shirley Lim, Jian Mi, Debbie Kalar, Matthew Eang, Erick Lorenzana-Saldivar, Edward P Chen, Akash Gupta, Philip Lau, Pablo Perez D’Empaire, Chantal Armali, Amie Malkin, Connie Colavecchia, Harley Meirovich, Annie Bergeron, Francois Laforge, Kim Paradis, Nathalie Gagne, Marie Soleil Saillant, Marie-Claude Vézina, Olivier Royer, Marie-Ève Charest, Lee-Anne Fochesato, Yuxin Bai, Iqbal Jaffar, Nour Alhomsi, Janine Guevarra, Erin Jamula, Wan Chien (Betty) Hsu, Abbey Drew, Hakan Buyukdere, Drashtee Patel, Elizabeth Watt, Hadia Arabi Katbi, Kim Luciano, Amy Moorehead, Kamola Kasimova, Farzana Tasmin, Cielo Bingley, Victoria Barkley, Tob Reegan, Marianna Qu, Jessica Xiong, Sophie Robichaud, Christy Peterson, Manu Jairath, Mathew Tang, Jennita Aariaratnam, Leron DuMerton, Lucas Drew, Sahrish Masood, Toni Tidy, Elizabeth Krok

Publikováno v: BMJ Open, Vol 14, Iss 8 (2024)

Introduction Reduced thrombin generation is an important component of post cardiopulmonary bypass (CPB) coagulopathy. To replenish coagulation factors and enhance thrombin generation in bleeding surgical patients, frozen plasma (FP) and four-factor p

Externí odkaz: https://doaj.org/article/f4b23ce7268143bca04256dccb1c3cbf

Some aspects of the development of information-cybernetic thinking in pedagogical university students when studying the basics of cybernetics

Autor: Robert Mayer

Publikováno v: Informatics and education. 37:65-73

The rapid development of various information-cybernetic systems and their introduction into all spheres of human life and activity necessitate a deeper study of the foundations of informatics and cybernetics in schools and pedagogical universities. C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9153ecd258d6c9faeafc53ff5ad1e097
https://doi.org/10.32517/0234-0453-2022-37-3-65-73

Didactic Complexity of Various Topics School Physics Course and Its Evaluation

Autor: Robert Mayer

Publikováno v: Standards and Monitoring in Education. 10:26-33

The article discusses the actual problem of assessing the didactic complexity of sufficiently large educational texts on the example of topics and sections of a school physics course. To determine the complexity of the text, the expert must: 1) divid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bf2d824716d0ca118bff613b05c56b3a
https://doi.org/10.12737/1998-1740-2022-10-2-26-33

Quantification of the hydride donor abilities of NADH, NADPH, and BH 3 CN − in water

Autor: Joseph Moran, Robert Mayer

Publikováno v: Organic & Biomolecular Chemistry
Organic & Biomolecular Chemistry, 2022, 21 (1), pp.85-88. ⟨10.1039/D2OB02041F⟩

The nucleophilic reactivities of the hydride donors NADH, NADPH, and BH3CN- in water were quantified using kinetic measurements with benzhydrylium ions as reference electrophiles. All three hydride donors were found to possess almost identical nucleo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02709d332458003c4fd1065ec0b83d86
https://hal.science/hal-04018706/document

Robert J. Mayer

Autor: Robert Mayer

Publikováno v: Angewandte Chemie (International ed. in English). 61(48)

"If I were not a scientist, I would be a problem-solver somewhere else … My biggest motivation is the prospect of being able to understand something very complex for the first time…" Find out more about Robert J. Mayer in his Introducing … Prof

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a41c43da955e17c9b02d113f5a039480
https://pubmed.ncbi.nlm.nih.gov/36316235