Enoxaparin treatment administered at both early and late stages of amyloid β deposition improves cognition of APPswe/PS1dE9 mice with differential effects on brain Aβ levels

Autor: Nienke M. Timmer, Laura van Dijk, Catharina E.E.M. van der Zee, Amanda Kiliaan, Robert M.W de Waal, Marcel M. Verbeek

Publikováno v: Neurobiology of Disease, Vol 40, Iss 1, Pp 340-347 (2010)

Enoxaparin (Enox), a low molecular weight heparin, has been shown to lower brain amyloid β (Aβ) load in a mouse model for Alzheimer's disease. However, the effect of Enox on cognition was not studied. Therefore, we examined the effect of peripheral

Externí odkaz: https://doaj.org/article/810253c00d384ac7a5f5b2a5ec336362

Neoadjuvant sorafenib treatment of clear cell renal cell carcinoma and release of circulating tumor fragments

Autor: Stijn Muselaers, J.C. Oosterwijk-Wakka, Cathy Maass, Peter F.A. Mulders, William P.J. Leenders, Ingrid M.E. Desar, Carla M.L. van Herpen, Robert M.W. de Waal, Han van Krieken, Christina A. Hulsbergen-van de Kaa, Mirjam de Weijert, Egbert Oosterwijk, Gursah Kats-Ugurlu

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 16, Iss 3, Pp 221-228 (2014)
Neoplasia, 16, 3, pp. 221-8
Neoplasia, 16, 221-8

Contains fulltext : 136369.pdf (Publisher’s version ) (Open Access) BACKGROUND: Clear cell renal cell carcinoma (ccRCC) is characterized by high constitutive vascular endothelial growth factor A (VEGF-A) production that induces a specific vascular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c52cd59b15fedd784a4ed8f84e6531c
https://hdl.handle.net/2066/136369

Explicit feedback to enhance the effect of an interim assessment: a cross-over study on learning effect and gender difference

Autor: Marleen Olde Bekkink, Rogier Donders, Robert M.W. de Waal, Goos N.P. van Muijen, Dirk J. Ruiter

Publikováno v: Perspectives on Medical Education, 1, 4, pp. 180-191
Perspectives on Medical Education
Perspectives on Medical Education, 1, 180-191

Contains fulltext : 107832.pdf (Publisher’s version ) (Open Access) In a previous study we demonstrated by a prospective controlled design that an interim assessment during an ongoing small group work (SGW) session resulted in a higher score in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca5524d72983f7c8f502b4494eb80010
https://doi.org/10.1007/s40037-012-0027-y

A rational design to create hybrid β-sheet breaker peptides to inhibit aggregation and toxicity of amyloid-β

Autor: Gijs Schaftenaar, Marcel M. Verbeek, Floris L. van Delft, Anna Karawajczyk, Ilona B. Bruinsma, Robert M.W. de Waal

Publikováno v: Medchemcomm, 2, 60-64
Medchemcomm, 2, 1, pp. 60-64

Alzheimer's disease is characterized by deposits of the amyloid β protein (Aβ) in the form of senile plaques and cerebral amyloid angiopathy. Deposition of Aβ into these pathological lesions is directed by step-wise aggregation of Aβ into oligome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7140f8f7bc0a3d89434caa3edce0522e
https://doi.org/10.1039/c0md00213e

Apolipoprotein E protects cultured pericytes and astrocytes from D-Abeta(1-40)-mediated cell death

Autor: Robert Veerhuis, Marcel M. Verbeek, Matthijs Kox, Ilona B. Bruinsma, Micha M.M. Wilhelmus, Robert M.W. de Waal

Publikováno v: Brain Research, 1315, 169-180. Elsevier
Bruinsma, I B, Wilhelmus, M M M, Kox, M, Veerhuis, R, de Waal, R M W & Verbeek, M M 2010, ' Apolipoprotein E protects cultured pericytes and astrocytes from D-A beta(1-40)-mediated cell death ', Brain Research, vol. 1315, pp. 169-180 . https://doi.org/10.1016/j.brainres.2009.12.039
Brain Research, 1315, 22 february, pp. 169-80
Brain Research, 1315, 169-80

Contains fulltext : 88262.pdf (Publisher’s version ) (Closed access) Cerebral amyloid angiopathy (CAA) is a common pathological finding in Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis of the Dutch type; in this latter con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef97781dd53a5560ba8a539a4227b4ee
https://doi.org/10.1016/j.brainres.2009.12.039