Výsledky vyhledávání - "Robert M. Winslow"

Autor: Robert M. Winslow

Publikováno v: Surgical technology international.

Blood substitutes are solutions intended to replace transfusion of banked red blood cells. Several variations of products based on either hemoglobin (animal or human) or perfluorocarbon emulsions are in advanced stages of clinical development. The ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eb7a1b4b21be87eafdf9bef20f2e81a
https://pubmed.ncbi.nlm.nih.gov/28581590

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Oxygen: the poison is in the dose

Autor: Robert M. Winslow

Publikováno v: Transfusion. 53:424-437

Cell-free hemoglobin (Hb) has been blamed for a spectrum of problems, including vasoconstriction pancreatitis, myocardial infarction, and pulmonary hypertension in hemolytic anemia, malaria, and sickle cell anemia, and from Hb-based oxygen carriers (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f390889aaf0bd58491c2b181adaa066
https://doi.org/10.1111/j.1537-2995.2012.03774.x

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Hemospan Improves Outcome in a Model of Perioperative Hemodilution and Blood Loss in the Rat: Comparison With Hydroxyethyl Starch

Autor: Kim D. Vandegriff, Jeff Lohman, Mark A. Young, Ashok Malavalli, Robert M. Winslow

Publikováno v: Journal of Cardiothoracic and Vascular Anesthesia. 23:339-347

Objectives Hemospan (Sangart Inc, San Diego, CA) (MP4) is a hemoglobin-based oxygen carrier consisting of human hemoglobin modified with polyethylene glycol. This study evaluated the effects of MP4 on blood volume, hemodynamics, and metabolic stabili

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https://doi.org/10.1053/j.jvca.2008.08.006

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Cell-free oxygen carriers: Scientific foundations, clinical development, and new directions

Autor: Robert M. Winslow

Publikováno v: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1784:1382-1386

The most significant hurdle to the development of a safe and effective hemoglobin-based oxygen carrier (“blood substitute”) is generally thought to be its propensity to cause vasoconstriction in the microcirculation and hypertension. Two theories

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83c84910c2eefb83fc709dc14de1db43
https://doi.org/10.1016/j.bbapap.2008.04.032

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CO-MP4, a polyethylene glycol-conjugated haemoglobin derivative and carbon monoxide carrier that reduces myocardial infarct size in rats

Autor: Kim D. Vandegriff, Ashok Malavalli, M A Young, Michele Samaja, Robert M. Winslow, J Lohman, Andrea Bellelli

Publikováno v: British Journal of Pharmacology. 154:1649-1661

Background and purpose: MP4 (Hemospan) is a Hb-based oxygen therapeutic agent, based on polyethylene-glycol (PEG) conjugation to Hb, undergoing clinical trials as an oxygen carrier. This study describes the functional interaction between MP4 and carb

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https://doi.org/10.1038/bjp.2008.219

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Red cell age and loss of function: advance or SNO-job?

Autor: Marcos Intaglietta, Robert M. Winslow

Publikováno v: Transfusion. 48:411-414

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea36b41c7cc957c35f61c438985c9e13
https://doi.org/10.1111/j.1537-2995.2008.01657.x

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A randomized, single-blind, increasing dose safety trial of an oxygen-carrying plasma expander (Hemospan®) administered to orthopaedic surgery patients with spinal anaesthesia

Autor: B. Fagrell, Robert M. Winslow, P. E. Keipert, Christina Olofsson, R. Przybelski, S. Ponzer, E. B. Nygårds, N. Winslow

Publikováno v: Transfusion Medicine. 18:28-39

The objective of this study was to further explore the safety of Hemospan (Sangart Inc., San Diego, CA, USA), an oxygen-carrying plasma expander. The aim of this study was to determine if Hemospan is well tolerated in orthopaedic surgery patients wit

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https://doi.org/10.1111/j.1365-3148.2007.00811.x

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Solution Structure of Poly(ethylene) Glycol-Conjugated Hemoglobin Revealed by Small-Angle X-Ray Scattering: Implications for a New Oxygen Therapeutic

Autor: Calle Nilsson, Fredrik Ekström, Dmitri I. Svergun, Kim D. Vandegriff, Robert M. Winslow, Dale Baker, Ashok Malavalli

Publikováno v: Biophysical journal 94, 173-181 (2008). doi:10.1529/biophysj.107.114314

Developing protein therapeutics has posed challenges due to short circulating times and toxicities. Recent advances using poly(ethylene) glycol (PEG) conjugation have improved their performance. A PEG-conjugated hemoglobin (Hb), Hemospan, is in clini

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The safety profile of Hemospan®: a new oxygen therapeutic designed using maleimide poly(ethylene) glycol conjugation to human hemoglobin

Autor: Peter Keipert, Kim D. Vandegriff, Robert M. Winslow, Mark A. Young

Publikováno v: Transfusion Alternatives in Transfusion Medicine. 9:213-225

SUMMARY Hemoglobin-based oxygen carriers have been under development for several decades, but so far none has completed clinical trials due to safety issues, including fundamental concerns regarding hemoglobin-induced vasoconstriction and oxidative r

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https://doi.org/10.1111/j.1778-428x.2007.00083.x

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