Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Robert M. Wenslow"'
Autor:
Bo Wang, Matthew J. Nethercott, Akshay Narula, Michael Hanrahan, Shanming Kuang, Robert M. Wenslow, Na Li
Publikováno v:
Pharmaceutical research. 39(11)
In amorphous solid dispersions (ASDs), the chemical potential of a drug can be reduced due to mixing with the polymer in the solid matrix, and this can lead to reduced drug release when the polymer is insoluble in the dissolution media. If both the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9587ec7ae8e0b72e434eb50754106f07
https://pubmed.ncbi.nlm.nih.gov/34890018
https://pubmed.ncbi.nlm.nih.gov/34890018
Autor:
Ann Newman, Robert M. Wenslow
Publikováno v:
Pharmaceutical Crystals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdc06d438383a4f81334e6db278ece9f
https://doi.org/10.1002/9781119046233.ch3
https://doi.org/10.1002/9781119046233.ch3
Publikováno v:
Therapeutic Delivery. 6:247-261
Amorphous solid dispersions (ASDs) are being used with increasing frequency for poorly soluble pharmaceutical compounds in development. These systems consist of an amorphous active pharmaceutical ingredient stabilized by a polymer to produce a system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31b2155e6a9100686f5ac9223ab93b75
https://doi.org/10.4155/tde.14.101
https://doi.org/10.4155/tde.14.101
Publikováno v:
CrystEngComm. 16:3141-3147
The crystal structure of a powder pharmaceutical cocrystal, theophylline–nicotinamide (1 : 1) crystal complex, is determined for the first time by using a combination of X-ray powder diffraction (XRPD), 1D solid state NMR, as well as density functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c02084ae4544b5989579ce8d8f2397a7
https://doi.org/10.1039/c4ce00012a
https://doi.org/10.1039/c4ce00012a
Publikováno v:
Journal of Pharmaceutical Sciences. 102:1915-1923
To improve the dissolution and hence the oral bioavailability, amorphous felodipine (FEL) solid dispersions (SDs) with Kollidon® VA 64 (PVP/VA) were prepared. Hot-melt extrusion was employed with an extruding temperature below the melting point (Tm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb74eed0336578d46c5ebab11f6b60ec
https://doi.org/10.1002/jps.23538
https://doi.org/10.1002/jps.23538
Autor:
Ann Newman, Robert M. Wenslow
Publikováno v:
AAPS Open, Vol 2, Iss 1, Pp 1-11 (2016)
The relevance of solid form in drug development has been well established over time. In order to fully understand drug properties, attention has been paid to solid state structure of drug molecules and their relationship to the drug formulation. Whil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ff3529ad891891c9c703a29997d5f6
https://doi.org/10.1186/s41120-016-0003-4
https://doi.org/10.1186/s41120-016-0003-4
Publikováno v:
Organic Process Research & Development. 12:271-281
The rationale and strategy for purification of partially resolved enantiomeric mixtures based on ternary phase diagrams are discussed. From the ternary phase diagram, one can deduce if a feasible process can be developed to upgrade the enantiomeric e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be1c326162791d146b8ba9decc693482
https://doi.org/10.1021/op7002387
https://doi.org/10.1021/op7002387
Publikováno v:
Journal of Chromatography A. 1156:25-34
Unique properties of the fluorine atom stimulate widespread use and development of new organofluorine compounds in agrochemistry, biotechnology and pharmacology applications. However, relatively few synthetic methods exhibit a high degree of fluorina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ee74c8e43681eba569727b550299f68
https://doi.org/10.1016/j.chroma.2007.05.033
https://doi.org/10.1016/j.chroma.2007.05.033
Publikováno v:
Pharmaceutical Sciences Encyclopedia
This chapter highlights common polymers and surfactants that have been used in various studies. Most polymers exhibit a range of molecular weights. Where possible, the grade, molecular weight, and glass transition temperature (Tg) are given in the ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11216cd12598d391ab96f0c2612e275f
https://doi.org/10.1002/9780470571224.pse535
https://doi.org/10.1002/9780470571224.pse535
Autor:
Alex M. Chen, Stephen Cypes, Robert M. Wenslow, Mahmoud Kaba, Jason G. Dorwart, John R. Corte, Scott M. Thomas
Publikováno v:
Organic Process Research & Development. 8:576-582
This contribution discusses the laboratory results and factory-scale drying of an organic monohydrate with therapeutic qualities. The crystal form instabilities of this monohydrate are discussed with respect to undesired dehydrated crystalline specie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a48887be255b6e4f509174792b8ef4d
https://doi.org/10.1021/op049956a
https://doi.org/10.1021/op049956a