Výsledky vyhledávání - "Robert M. Valerio"

Synthesis of O-phosphonotyrosyl peptides

Autor: Bruce E. Kemp, Paul F. Alewood, Robert M. Valerio, R. B. Johns

Publikováno v: International Journal of Peptide and Protein Research. 33:428-438

A general method for the synthesis of O-phosphonotyrosyl peptides using solid phase methodology is described. Protected O-phosphonotyrosine derivatives with the general structure Boc-Tyr(R2PO3)-OH (R = methyl, ethyl or benzyl) were prepared as potent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed07f4329105acad7386a6136f78ac72
https://doi.org/10.1111/j.1399-3011.1989.tb00219.x

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Multipin solid phase synthesis of ethers using modified Mitsunobu chemistry

Autor: Andrew M. Bray, Robert M. Valerio, Heather Patsiouras

Publikováno v: Tetrahedron Letters. 37:3019-3022

Formation of ether derivatives of phenolic containing structures using solid phase Mitsunob functionalized polyethylene pins was investigated. Using the Multipin approach, a range of reaction parameters were systematically varied in parallel experime

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a65a5162a990ca11c8e6e38dd52b10d3
https://doi.org/10.1016/0040-4039(96)00458-3

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Sonication-assisted cleavage of hydrophobic peptides. Application in multipin peptide synthesis

Autor: Robert M. Valerio, Liana M. Lagniton, Andrew M. Bray, N. Joe Maeji

Publikováno v: Tetrahedron Letters. 35:9079-9082

High-power sonication enables hydrophobic peptides, that would otherwise cleave with poor efficiency, to cleave and elute from the solid support in good yield. The method is demonstrated in conjunction with the multipin method of multiple synthesis u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e75f212421e01443694939e659c93724
https://doi.org/10.1016/0040-4039(94)88433-1

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Grafted supports used with the multipin method of peptide synthesis

Autor: H. Mario Geysen, Rhonda A. Campbell, N. Joe Maeji, Andrew M. Bray, Robert M. Valerio

Publikováno v: Reactive Polymers. 22:203-212

Radiation grafting of a range of monomers allows a diversity of surface characteristics to be generated on a common plastic support. Taken together with the modular 8-column, 12-row format used with the multipin method of peptide synthesis, many thou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2b8bef7e4a5f2cf58a2aad51fb7cea47
https://doi.org/10.1016/0923-1137(94)90118-x

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Simultaneous Multiple Synthesis of Peptide Amides by the Multipin Method. Application of Vapor-Phase Ammonolysis

Autor: Robert M. Valerio, Andrew M. Bray, Akhil G. Jhingran, N. Joe Maeji

Publikováno v: The Journal of Organic Chemistry. 59:2197-2203

A method for simultaneously preparing large numbers of peptide amides is described. Side-chain deprotected, support-bound peptide esters (1) and (2) are incubated with ammonia/tetrahydrofuran vapor. The cleaved peptide amides (3) are then eluted from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d8a7d4e2ccc8044a0c3454beaa3806ff
https://doi.org/10.1021/jo00087a041

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Cleavage of resin-bound peptide esters with ammonia vapour. Simultaneous multiple synthesis of peptide amides

Autor: Robert M. Valerio, Andrew M. Bray, N. Joe Maeji

Publikováno v: Tetrahedron Letters. 34:4411-4414

Peptides prepared on Pepsyn KB resin were cleaved with ammonia/tetrahydrofuran vapour and then eluted from the resin in a two step process. The method is a general one, applicable to simultaneous multiple peptide synthesis on resin supports.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3009b0f0cb05ca2eeee71a03abc760f7
https://doi.org/10.1016/s0040-4039(00)79366-x

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Endothelin eceptor Ligands. Multiple D-Amino acid replacement net approach

Autor: H. Mario Geysen, David C. Spellmeyer, Suzy Brown, Robert M. Valerio, Gregory B. Stauber

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 3:1253-1256

All possible single and multiple L- to D- amino acid replacements of a potent hexapeptide endothelin receptor ligand were synthesized and tested. While most of these 64 analogues were inactive on the ETRA receptor, three showed submicromolar activity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1d086ed9e2e6cc0cfe69f1c98d8817d9
https://doi.org/10.1016/s0960-894x(00)80326-1

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Endothelin receptor ligands. replacement net approach to SAR determination of potent hexapeptides

Autor: Robert M. Valerio, Gregory B. Stauber, Suzy Brown, David C. Spellmeyer, H. Mario Geysen

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 3:519-524

We determined the SAR of the potent hexapeptide endothelin ligand Ac-Dphe-Orn-Asp-Ile-Ile-Trp-OH1 (1) through the systematic replacement of each residue with 50 amino acid substitutes. Multipin peptide synthesis methods allowed us to rapidly synthesi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4131b405cd79a39b8b93822fe42417a4
https://doi.org/10.1016/s0960-894x(01)81219-1

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