Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Robert M. Tombes"'
Publikováno v:
PLoS Genetics, Vol 19, Iss 12, p e1011102 (2023)
Acute lymphoblastic leukemia/lymphoma (ALL) is the most common pediatric cancer and is a malignancy of T or B lineage lymphoblasts. Dysregulation of intracellular Ca2+ levels has been observed in patients with ALL, leading to improper activation of d
Externí odkaz:
https://doaj.org/article/a8847c528dd041ef9bf13daa3f168aa8
Autor:
Sarah C, Rothschild, Robert M, Tombes
Publikováno v:
Advances in experimental medicine and biology. 1131
The multifunctional Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a3d708892687e286cf7e6176d70d8bc7
https://pubmed.ncbi.nlm.nih.gov/31646524
https://pubmed.ncbi.nlm.nih.gov/31646524
Autor:
Sarah C. Rothschild, Robert M. Tombes
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9783030124564
The multifunctional Ca2+/calmodulin-dependent protein kinase type 2 (CaMK-II) was first discovered in brain tissue and shown to have a central role in long term potentiation, responding to Ca2+ elevations through voltage dependent channels. CaMK-II h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47506e1d849298578643f8cbccd1411e
https://doi.org/10.1007/978-3-030-12457-1_21
https://doi.org/10.1007/978-3-030-12457-1_21
Autor:
Fu I. Lu, Robert M. Tombes, Sarah C. Rothschild, Sarah R. Ingram, Jamie A. Parkerson, Christine Thisse, Bernard Thisse
Publikováno v:
Gene. 742:144567
CaMKII is a Ca2+/CaM-dependent protein kinase encoded by a family of conserved genes found throughout all metazoan species and expressed from fertilization into adulthood. One of these genes, camk2g1, is particularly important during early developmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a001367d41f94f8c5f4492ab454c9f1a
https://doi.org/10.1016/j.gene.2020.144567
https://doi.org/10.1016/j.gene.2020.144567
Autor:
Gregory S. Walsh, Hunter J. Lee, Daniel K. Mohammadi, Sarah C. Rothschild, Sarah R. Ingram, Robert M. Tombes
Publikováno v:
Developmental dynamics : an official publication of the American Association of Anatomists. 247(6)
BACKGROUND Autosomal dominant polycystic kidney disease is the most common monogenetic kidney disorder and is linked to mutations in PKD1 and PKD2. PKD2, a Ca2+ -conducting TRP channel enriched in ciliated cells and gated by extracellular signals, is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6a1fd93979b04640e6888ca342f79e2
https://pubmed.ncbi.nlm.nih.gov/29633426
https://pubmed.ncbi.nlm.nih.gov/29633426
Autor:
Robert M. Tombes, Sarah C. Rothschild, Jamie L. Lahvic, Jamie Josephine Avila McLeod, Ludmila Francescatto, Shawn M. Burgess
Publikováno v:
Developmental Biology. 381:179-188
Zebrafish inner ear development is characterized by the crystallization of otoliths onto immotile kinocilia that protrude from sensory “hair” cells. The stereotypical formation of these sensory structures is dependent on the expression of key pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22eaa35eb92016f5076fe61af0016547
https://doi.org/10.1016/j.ydbio.2013.05.028
https://doi.org/10.1016/j.ydbio.2013.05.028
Publikováno v:
Chemistry & Biodiversity. 10:338-342
Proton hopping is the process where a H-atom on a hydronium ion forms a H-bond with the O-atom of a neighboring H(2)O molecule. There is then an exchange of bonding forces when that covalent bond of the H-atom in the hydronium ion changes to a H-bond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::689be94174eda70001c9b8a80aaddad8
https://doi.org/10.1002/cbdv.201200178
https://doi.org/10.1002/cbdv.201200178
Publikováno v:
Journal of Visualized Experiments.
The rapid proliferation of cells, the tissue-specific expression of genes and the emergence of signaling networks characterize early embryonic development of all vertebrates. The kinetics and location of signals - even within single cells - in the de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::802ad80caa35b1255b5cb0d0e7b974bc
https://doi.org/10.3791/53747-v
https://doi.org/10.3791/53747-v
Publikováno v:
Development. 137:2753-2762
Intracellular calcium ion (Ca(2+)) elevation on the left side of the mouse embryonic node or zebrafish Kupffer's vesicle (KV) is the earliest asymmetric molecular event that is functionally linked to lateral organ placement in these species. In this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9d3a626c2a6be5853fe027b7c715ecb
https://doi.org/10.1242/dev.049627
https://doi.org/10.1242/dev.049627
Publikováno v:
Chemical Research in Toxicology. 21:732-738
We recently reported the protective effect of 2-hydroxy- cis-terpenone (HCT) against aflatoxin B 1 (AFB1)-induced cytotoxicity in human HepG2 liver cells ( Zhou et al. Chem. Res. Toxicol. 2006, 19, 1415-1419 ); however, the mechanism was not clear. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceedc91fa85aaede04b4d855ab5458da
https://doi.org/10.1021/tx700363s
https://doi.org/10.1021/tx700363s