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Discovery of 2-Phenylamino-imidazo[4,5-h]isoquinolin-9-ones: A New Class of Inhibitors of Lck Kinase
Autor:
Maret Panzenbeck, Mario G. Cardozo, Robert M. Tolbert, Jeffrey D. Peterson, Susan Lukas, Stephen Jacober, Robert J. Eckner, Gregory W. Peet, Anthony S. Prokopowicz, Carl A. Busacca, Suresh R. Kapadia, Scott Jakes, Tina Morwick, Roger J. Snow, Rosemarie Sellati, Yong Dong, Matt Aaron Tschantz, Neil Moss
Publikováno v:
Journal of Medicinal Chemistry. 45:3394-3405
An imidazo[4,5-h]isoquinolin-7,9-dione (1) was identified as an adenosine 5'-triphosphate competitive inhibitor of lck by high throughput screening. Initial structure-activity relationship studies identified the dichlorophenyl ring and the imide NH a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcb66ed0ff6ce36eb079aaec851fb78a
https://doi.org/10.1021/jm020113o
https://doi.org/10.1021/jm020113o
