Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Robert M. Owen"'
Autor:
Robert M. Owen, MD, Christopher Eppel, MD, Michael Platten, BS, Marianne Tanios, MD, MPH, Luis Tollinche, MD, FASA
Publikováno v:
Heliyon, Vol 10, Iss 6, Pp e27486- (2024)
Spontaneous intraoperative development of Mobitz II second-degree atrioventricular block is a rare event which requires decisive action on the part of anesthesiologists and anesthetists. Given that this arrhythmia can be fatal if not properly managed
Externí odkaz:
https://doaj.org/article/047a10ff6a494cb0a118acb72cdee4a7
Autor:
Robert M. Owen, Kevin W. Chung
Publikováno v:
Advanced Anesthesia Review ISBN: 0197584527
Ventilator-associated pneumonia (VAP) is a serious nosocomial infection that is often encountered in the critical care setting. While there is no firm consensus on the “gold standard” of diagnosis; it is most broadly accepted to be a pneumonia th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15109f4d1a4c1eea55c1e5326f00016b
https://doi.org/10.1093/med/9780197584521.003.0357
https://doi.org/10.1093/med/9780197584521.003.0357
Autor:
Daniel K. Gehlhaar, Brock A. Luty, Philip P. Cheung, Andy H. Litman, Robert M. Owen, Peter W. Rose
Publikováno v:
Journal of computational chemistryREFERENCES. 43(15)
Pfizer's Crystal Structure Database (CSDB) is a key enabling technology that allows scientists on structure-based projects rapid access to Pfizer's vast library of in-house crystal structures, as well as a significant number of structures imported fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b356f15664702f08f10419b931a8aab5
https://pubmed.ncbi.nlm.nih.gov/35394655
https://pubmed.ncbi.nlm.nih.gov/35394655
Autor:
Jared W. Feinman, Lourdes Al Ghofaily, Saumil Patel, Selina Read, Matthew M. Townsley, Archit Sharma, Lovkesh Arora, Sudhakar Subramani, Himani V. Bhatt, Arun L. Jayaraman, Robert M. Owen, Archer Kilbourne Martin, Menachem M. Weiner, Anita Malhotra, Harish Ramakrishna, Miguel Teixeira, Ashley V. Fritz, Elizabeth Zhou
Publikováno v:
Journal of cardiothoracic and vascular anesthesia. 36(4)
This special article is the fourteenth in an annual series for the Journal of Cardiothoracic and Vascular Anesthesia. The authors thank the Editor-in-Chief, Dr. Kaplan, and the editorial board for the opportunity to continue this series; namely, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::557340c8fa75bee40bb587e65bafe249
https://pubmed.ncbi.nlm.nih.gov/34801393
https://pubmed.ncbi.nlm.nih.gov/34801393
Autor:
R. Ian Storer, Ron O. Dror, Robert M. Owen, Nigel Alan Swain, Brendan D. Kelly, Rubben Torella, Deniz Aydin, David C. Blakemore, Scott A. Hollingsworth, Joseph S. Warmus
Publikováno v:
Journal of chemical information and modeling. 61(7)
Biased agonists, which selectively stimulate certain signaling pathways controlled by a G protein-coupled receptor (GPCR), hold great promise as drugs that maximize efficacy while minimizing dangerous side effects. Biased agonists of the μ-opioid re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34fce4761cde5863816578587db42482
https://pubmed.ncbi.nlm.nih.gov/34251810
https://pubmed.ncbi.nlm.nih.gov/34251810
Autor:
Alan Sim, Joshua Hamburger, Benjamin Salter, Garrett Burnett, Jaime B. Hyman, Elisha Dickstein, Daniel Katz, Andrew B. Leibowitz, Matthew A. Levin, Chang H. Park, Robert M. Owen
Publikováno v:
Journal of Anesthesia
In March 2020, the New York City metropolitan area became the epicenter of the United States' SARS-CoV-2 pandemic and the surge of new cases threatened to overwhelm the area's hospital systems. This article describes how an anesthesiology department
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b616f992e379d9c93e1793aaf43dfb2c
https://pubmed.ncbi.nlm.nih.gov/33006071
https://pubmed.ncbi.nlm.nih.gov/33006071
Autor:
Cathleen Hsu, Robert M. Owen, Evan D. Morris, Gang Feng, Guido van Amerongen, Andy N. Mead, Sarah A. Nickolls, David S. Reynolds, Lishuang Cao, Juha Kammonen, Clara Stead, Ruolun Qiu, Donal Gorman, Richard P. Butt, Adam R. Brown, Joop M. A. van Gerven, Rachel Gurrell, Christine Anne Louise Watson, Mark Whitlock, Laigao Chen, Rebecca L. Fish, Andrew Pike, Pinky Dua
Publikováno v:
British Journal of Pharmacology. 175:708-725
Background and purpose Benzodiazepines, non-selective positive allosteric modulators (PAMs) of GABAA receptors, have significant side effects that limit their clinical utility. As many of these side effects are mediated by the α1 subunit, there has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da051882a6b4724d68b80dbf86c2760e
https://doi.org/10.1111/bph.14119
https://doi.org/10.1111/bph.14119
Autor:
Robert M, Owen, David, Blakemore, Lishuang, Cao, Neil, Flanagan, Rebecca, Fish, Karl R, Gibson, Rachel, Gurrell, Chan Woo, Huh, Juha, Kammonen, Elisabeth, Mortimer-Cassen, Sarah A, Nickolls, Kiyoyuki, Omoto, Dafydd, Owen, Andy, Pike, David C, Pryde, David S, Reynolds, Rosemarie, Roeloffs, Colin, Rose, Clara, Stead, Mifune, Takeuchi, Joseph S, Warmus, Christine, Watson
Publikováno v:
Journal of medicinal chemistry. 62(12)
The design, optimization, and evaluation of a series of novel imidazopyridazine-based subtype-selective positive allosteric modulators (PAMs) for the GABA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1b852c98ab428508fb3c4d5969e61528
https://pubmed.ncbi.nlm.nih.gov/30964988
https://pubmed.ncbi.nlm.nih.gov/30964988
Autor:
Colin R. Rose, Elisabeth Mortimer-Cassen, Juha Kammonen, Rebecca L. Fish, David C. Pryde, Lishuang Cao, Sarah A. Nickolls, Neil J. Flanagan, Karl Richard Gibson, Joseph S. Warmus, Christine Anne Louise Watson, Chan Woo Huh, David J. Reynolds, Rachel Gurrell, Kiyoyuki Omoto, Andrew Pike, Clara Stead, David C. Blakemore, Rosemarie Roeloffs, Dafydd R. Owen, Mifune Takeuchi, Robert M. Owen
Publikováno v:
Journal of Medicinal Chemistry.
The design, optimization, and evaluation of a series of novel imidazopyridazine-based subtype-selective positive allosteric modulators (PAMs) for the GABAA ligand-gated ion channel are described. From a set of initial hits multiple subseries were des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69244f4f78fe59a3b806c142bdaa534b
https://doi.org/10.1021/acs.jmedchem.9b00322
https://doi.org/10.1021/acs.jmedchem.9b00322
Autor:
R. Ian Storer, Robert M. Owen, Emma Impey, Alex Gutteridge, Parul Choudhary, Caroline L. Benn, Magda Bictash, Paul J. Whiting
Publikováno v:
Stem Cells Translational Medicine. 5:925-937
Retinal pigment epithelium (RPE) cell integrity is critical to the maintenance of retinal function. Many retinopathies such as age-related macular degeneration (AMD) are caused by the degeneration or malfunction of the RPE cell layer. Replacement of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6849e06247da77ed9a0f131d1e956d29
https://doi.org/10.5966/sctm.2015-0247
https://doi.org/10.5966/sctm.2015-0247