Zobrazeno 1 - 10 of 211 pro vyhledávání: '"Robert M. Mentzer"'
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Akademický článek
Intermittent Use of a Short-Course Glucagon-like Peptide-1 Receptor Agonist Therapy Limits Adverse Cardiac Remodeling via Parkin-dependent Mitochondrial Turnover
Autor: Juliana de F. Germano, Chengqun Huang, Jon Sin, Yang Song, Kyle C. Tucker, David J. R. Taylor, Hannaneh Saadaeijahromi, Aleksandr Stotland, Honit Piplani, Roberta A. Gottlieb, Robert M. Mentzer, Allen M. Andres
Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract Given that adverse remodeling is the leading cause of heart failure and death in the USA, there is an urgent unmet need to develop new methods in dealing with this devastating disease. Here we evaluated the efficacy of a short-course glucago
Externí odkaz: https://doaj.org/article/bdb64149fffc46618c22d0b61e814c7a
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2
Attenuation of Adverse Postinfarction Left Ventricular Remodeling with Empagliflozin Enhances Mitochondria-Linked Cellular Energetics and Mitochondrial Biogenesis
Autor: Yang Song, Chengqun Huang, Jon Sin, Juliana de F. Germano, David J. R. Taylor, Reetu Thakur, Roberta A. Gottlieb, Robert M. Mentzer, Allen M. Andres
Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 23, Iss 437, p 437 (2022)
International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 437
Sodium–glucose cotransporter 2 (SGLT2) inhibitors such as empagliflozin are known to reduce the risk of hospitalizations related to heart failure irrespective of diabetic state. Meanwhile, adverse cardiac remodeling remains the leading cause of hea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::136e7668f430e63bd67b758247a61956
https://pubmed.ncbi.nlm.nih.gov/35008865
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3
The Role of Reactive Oxygen Species, Kinases, Hydrogen Sulfide, and Nitric Oxide in the Regulation of Autophagy and Their Impact on Ischemia and Reperfusion Injury in the Heart
Autor: Alla A. Boshchenko, Robert M. Mentzer, A. V. Krylatov, James M. Downey, Leonid N. Maslov, Sergey Y Tsibulnikov, Nikita S. Voronkov
Publikováno v: Curr Cardiol Rev
There is considerable evidence that autophagy in cardiomyocytes is activated by hypoxia/ reoxygenation (H/R) or in hearts by ischemia/reperfusion (I/R). Depending upon the experimental model and duration of ischemia, increases in autophagy in this se
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ce6354e8a75945d53377751ad07e03e
https://europepmc.org/articles/PMC8762158/
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4
Proteomics of Mouse Heart Ventricles Reveals Mitochondria and Metabolism as Major Targets of a Post-Infarction Short-Acting GLP1Ra-Therapy
Autor: Roberta A. Gottlieb, Allen M. Andres, Angie Aceves, Ankush Sharma, Honit Piplani, Marianne Aniag, Miroslava Stastna, Robert M. Mentzer, Jennifer E. Van Eyk, Juliana de Freitas Germano, Chengqun Huang
Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 16
International Journal of Molecular Sciences, Vol 22, Iss 8711, p 8711 (2021)
Cardiovascular disease is the main cause of death worldwide, making it crucial to search for new therapies to mitigate major adverse cardiac events (MACEs) after a cardiac ischemic episode. Drugs in the class of the glucagon-like peptide-1 receptor a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe093b66f40add3b74230b54d34b879a
https://pubmed.ncbi.nlm.nih.gov/34445425
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5
Myocardial hypothermia increases autophagic flux, mitochondrial mass and myocardial function after ischemia-reperfusion injury
Autor: Amandine Thomas, Robert M. Mentzer, Jon Sin, Fardad Esmailian, Annunziata N. Crupi, Lawrence S.C. Czer, Jean Hou, Allen M. Andres, David J. Taylor, Stefanie Marek-Iannucci, Roberta A. Gottlieb
Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-17 (2019)
Scientific Reports
Scientific reports, vol 9, iss 1
Animal studies have demonstrated beneficial effects of therapeutic hypothermia on myocardial function, yet exact mechanisms remain unclear. Impaired autophagy leads to heart failure and mitophagy is important for mitigating ischemia/reperfusion injur
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d14f14abe1be55c52246a95fca7f41d
http://link.springer.com/article/10.1038/s41598-019-46452-w
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6
Intermittent Use of a Short-Course Glucagon-like Peptide-1 Receptor Agonist Therapy Limits Adverse Cardiac Remodeling via Parkin-dependent Mitochondrial Turnover
Autor: Chengqun Huang, Robert M. Mentzer, Yang Song, Allen M. Andres, Juliana de Freitas Germano, Aleksandr Stotland, Roberta A. Gottlieb, Hannaneh Saadaeijahromi, Kyle C Tucker, Honit Piplani, David J. R. Taylor, Jon Sin
Publikováno v: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Given that adverse remodeling is the leading cause of heart failure and death in the USA, there is an urgent unmet need to develop new methods in dealing with this devastating disease. Here we evaluated the efficacy of a short-course glucagon-like pe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8823ff5a0c8358b68802a958acc9ef6
https://doi.org/10.1038/s41598-020-64924-2
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7
Hybrid Continuous-Flow Total Artificial Heart
Autor: Carson S. Fox, Steven G. Chopski, Paul E. Allaire, Robert M. Mentzer, Joseph W. Rossano, Nohra M. Murad, Francisco A. Arabia, Amy L. Throckmorton
Publikováno v: Artificial Organs. 42:500-509
Clinical studies using total artificial hearts (TAHs) have demonstrated that pediatric and adult patients derive quality-of-life benefits from this form of therapy. Two clinically-approved TAHs and other pumps under development, however, have design
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::88be7a31191ef524450a1802c97606e7
https://doi.org/10.1111/aor.13080
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8
Abstract 395: Pioglitazone and Glucagon-like Peptide 1 Receptor Agonist Mitigate Adverse Postinfarction Left Ventricular Remodeling in Lean Mice When Administered After the Infarct Independent of Changes in Infarct Size
Autor: Juliana de Freitas Germano, Yang Song, Allen M. Andres, Robert M. Mentzer, Chengqun Huang, Roberta A. Gottlieb, Kyle C Tucker, Jon Sin
Publikováno v: Circulation Research. 123
Pioglitazone (PIO) and GLP-1R receptor agonist (GLP1Ra) have been shown to be cardioprotective against ischemic cardiac injury. Much less is known about the effects of these agents on adverse post-MI LV remodeling. Based on our earlier findings that
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c0d076057a35c21d5c6ba0dd89bf2810
https://doi.org/10.1161/res.123.suppl_1.395
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9
Abstract 398: GLP-1 Receptor Agonist Administered After the Infarct Suppresses miR-33 Expression in Lean Mice Subjected to Permanent Coronary Artery Occlusion
Autor: Yang Song, Jon Sin, Allen M. Andres, Juliana de Freitas Germano, Robert M. Mentzer, Roberta A. Gottlieb, Chengqun Huang
Publikováno v: Circulation Research. 123
MicroRNAs (miRs) regulate post-transcriptional gene expression and protein translation. There is now increasing evidence that miRs regulate mitochondrial turnover. miR-33 regulates cholesterol metabolism and mitochondrial function in cardiac fibrobla
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a6cde6fcd4fe2d5717be866ba851bc9e
https://doi.org/10.1161/res.123.suppl_1.398
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10
Abstract 523: Pioglitazone and Glucagon-like Peptide 1 Receptor Agonist Stimulate Mitochondrial Turnover in the Heart When Administered After the Infarct in Obese Mice
Autor: Allen M Andres, Juliana Germano, Chengqun Huang, Kyle C Tucker, Yang Song, Jon Sin, Roberta A Gottlieb, Robert M Mentzer
Publikováno v: Circulation Research. 123
Randomized clinical trials have demonstrated that pioglitazone (PIO), a thiazolidinedione, and liraglutide and semaglutide, glucagon-like peptide-1 receptor agonists (GLP1Ra), are effective in treating Type 2 diabetes mellitus. Of considerable intere
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::804225f1817e4bd489f71f2b9e41c47e
https://doi.org/10.1161/res.123.suppl_1.523
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