Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Robert M. Long"'
Autor:
Manuel Regier, Carolin Christina Drost, Matthias Rauen, Hermann Pavenstädt, Alexandros Rovas, Philipp Kümpers, Hans Vink, Robert M. Long, Wolfgang A. Linke, Jerzy-Roch Nofer, Alexander-Henrik Lukasz
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 24, p 15520 (2022)
(1) Damage to the endothelial glycocalyx (eGC), a protective layer lining the endothelial luminal surface, is associated with chronic kidney disease (CKD), which leads to a worsening of cardiovascular outcomes in these patients. Currently, there are
Externí odkaz:
https://doaj.org/article/aac2b804be91429bba9123b97fe19df0
Publikováno v:
Phytochemistry. 91:208-219
A UPLC-MS method was developed for quantifying huperzine A (HupA), an anti-Alzheimer's disease (AD) drug candidate from the traditional Chinese medicine Qian Ceng Ta (Huperzia serrata), in samples of 11 Huperzia genus plants. The highest content of H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8b912e59924c9710793799687fe9fae
https://doi.org/10.1016/j.phytochem.2012.11.012
https://doi.org/10.1016/j.phytochem.2012.11.012
Publikováno v:
Archives of Biochemistry and Biophysics. 477:384-389
The last few steps in the biosynthesis of the anticancer drug Taxol in yew (Taxus) species are thought to involve the attachment of beta-phenylalanine to the C13-O-position of the advanced taxane diterpenoid intermediate baccatin III to yield N-deben
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c65f64cff66cf3627787513e1b1dfa
https://doi.org/10.1016/j.abb.2008.06.021
https://doi.org/10.1016/j.abb.2008.06.021
Publikováno v:
Phytochemistry Reviews. 5:75-97
Biosynthesis of the anticancer drug Taxol in Taxus (yew) species involves 19 steps from the universal diterpenoid progenitor geranylgeranyl diphosphate derived by the plastidial methyl erythritol phosphate pathway for isoprenoid precursor supply. Fol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ce13d633656ed430712231c01d5aadc
https://doi.org/10.1007/s11101-005-3748-2
https://doi.org/10.1007/s11101-005-3748-2
Autor:
Robert M. Long, Hangil Park, Stefan Jennewein, Arthur P. Bollon, Rodney Croteau, JingHong M. DeJong
Publikováno v:
Biotechnology and Bioengineering. 89:588-598
To maximize redox coupling efficiency with recombinant cytochrome P450 hydroxylases from yew (Taxus) species installed in yeast for the production of the anticancer drug Taxol, a cDNA encoding NADPH:cytochrome P450 reductase from T. cuspidata was iso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9db7c609adb41467c49891cf3ec9ce39
https://doi.org/10.1002/bit.20390
https://doi.org/10.1002/bit.20390
Autor:
Robert M. Long, Yule Liu, Arthur P. Bollon, Stefan Jennewein, Rodney Croteau, David G. Williams, JingHong M. DeJong
Publikováno v:
Biotechnology and bioengineering. 93(2)
Baccatin III, an intermediate of Taxol biosynthesis and a useful precursor for semisynthesis of the anti-cancer drug, is produced in yew (Taxus) species by a sequence of 15 enzymatic steps from primary metabolism. Ten genes encoding enzymes of this e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0dbef196632703da63829a8138134f5
https://pubmed.ncbi.nlm.nih.gov/16161138
https://pubmed.ncbi.nlm.nih.gov/16161138
Autor:
Robert M. Long, Rodney Croteau
Publikováno v:
Biochemical and biophysical research communications. 338(1)
The biosynthesis of the anticancer drug Taxol in yew (Taxus) species is thought to involve the preliminary formation of the advanced taxane diterpenoid intermediate baccatin III upon which the functionally important N-benzoyl phenylisoserinoyl side c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd04236324cea762c3618daf2aba48e1
https://pubmed.ncbi.nlm.nih.gov/16137660
https://pubmed.ncbi.nlm.nih.gov/16137660
Publikováno v:
Archives of biochemistry and biophysics. 430(2)
In addition to the anticancer drug Taxol, yew (Taxus) species produce a large variety of other taxane diterpenoids which differ mainly in the type of acyl and aroyl groups appended to the many hydroxyl functions on the taxane core; acetate esters are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a414fa3060fb474da3a85383c0eca856
https://pubmed.ncbi.nlm.nih.gov/15369823
https://pubmed.ncbi.nlm.nih.gov/15369823
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 99(20)
The structural pharmacophore of Taxol, responsible for binding the N terminus of the β-subunit of tubulin to arrest cell proliferation, comprises, in part, the 13- O -( N -benzoyl-3-phenylisoserinoyl) side chain. To identify the side chain transfera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::410fa519a789dbfcf87ea43048211993
https://pubmed.ncbi.nlm.nih.gov/12232048
https://pubmed.ncbi.nlm.nih.gov/12232048
The formation of several acyl groups and an amide group of Taxol is catalyzed by regioselective CoA thioester-dependent acyltransferases. Several full-length acyltransferase sequences, obtained from a cDNA library constructed from mRNA isolated from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fec145cc54b92a224a09b27c25c6d5a7
https://europepmc.org/articles/PMC123112/
https://europepmc.org/articles/PMC123112/
