Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Robert M. Kovatch"'
Publikováno v:
Reproductive Toxicology. 17:327-334
Two generations of “Ranch Wild” mink ( Mustela vison ) were fed the organophosphate diisopropyl methylphosphonate (DIMP) at 0, 150, 450, or 1250 ppm, to determine potential toxicity to the dams. Chemical, hematologic, necropsy, and microscopic ex
Publikováno v:
Toxicologic Pathology. 29:379-386
The carcinogenicity of fumonisin B1 (FB1), a worldwide contaminant of corn produced by Fusaria species of fungi, has been tested recently in 2-year feeding studies in Fischer F344 rats and B6C3F1 mice. Inclusion of FB1 at 50 and 80 ppm in the diet in
Autor:
Gary A. Boorman, David L. McCormick, John C. Findlay, Robert M. Kovatch, James R. Hailey, Robert C. Sills, Tim R. Johnson, Joseph K. Haseman, James R. Gauger
Publikováno v:
Toxicologic Pathology. 27:267-278
A 2-yr whole-body exposure study was conducted to evaluate the chronic toxicity and possible oncogenicity of 60 Hz (power frequency) magnetic fields in rats. Groups of 100 male and 100 female F344/N rats were exposed continuously to pure, linearly po
Autor:
Jeffrey D. Ceci, Robert M. Kovatch, Christos Patriotis, Christos Tsatsanis, Philip N. Tsichlis, Nancy A. Jenkins, Antonios M. Makris, Deborah A. Swing, Neal G. Copeland
Publikováno v:
Genes & Development. 11:688-700
Provirus insertion in the last intron of the Tpl-2 gene in retrovirus-induced rat T-cell lymphomas results in the enhanced expression of a carboxy-terminally truncated Tpl-2 kinase. Here we show that the truncated protein exhibits an approximately se
Autor:
Stasia Ruskie, Charles M. Riggs, Lucy M. Anderson, Robert M. Kovatch, Daniel Logsdon, Haleem J. Issaq, Stephen D. Fox
Publikováno v:
Carcinogenesis. 15:2245-2248
Polychlorinated biphenyls (PCB), which are tumor promoters, have been found in human tissues for decades. Their contribution to cancer risk may only now start to appear, due to long human cancer latency and the nature of tumor promotion. Epidemiologi
Autor:
Yooson E. Kim, Lucy M. Anderson, Robert M. Kovatch, Shantu Amin, Lisa E. Beebe, Charles W. Riggs
Publikováno v:
Carcinogenesis. 14:1545-1548
We have previously shown a positive tumor-promoting effect of a single dose of Aroclor 1254 on lung and liver tumors initiated neonatally in the mouse by N-nitrosodimethylamine (NDMA). In this study, we have confirmed and extended this observation wi
Publikováno v:
Carcinogenesis. 14:1189-1193
Metabolites produced by enzymic oxidation are believed to be responsible for the mutagenicity and carcinogenicity of N-nitrosamines. Although alpha-hydroxy compounds are often considered, a related and more stable oxidation product, the alpha-carbony
Autor:
Robert M. Kovatch, William Lijinsky
Publikováno v:
Toxicology and Industrial Health. 8:267-271
The industrial chemical glycidol is a directly acting mutagen and a broadly acting carcinogen in rats. It was administered to Syrian golden hamsters (20 male and 20 female) by gavage of 12 mg twice a week for 60 weeks. The total dose per animal was 1
Publikováno v:
Cancer Letters. 63:101-107
Two N-nitroso compounds that are derivatives of N,N-dimethylethylenediamine and are therefore strongly basic, were tested for carcinogenic activity. They were methylnitrosamino-N,N-dimethylethylamine (MNDMEA) and N,N-dimethylaminoethylnitrosoethylure
Publikováno v:
Carcinogenesis. 13:1293-1297
The carcinogenic effects of combinations of methapyrilene hydrochloride (MP), nitrosodiethylamine (NDEA), and phenobarbital (PB) or partial hepatectomy (PH) were examined following sequential treatment of rats. MP is a generally non-genotoxic liver c