Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Robert M. Hysmith"'
Publikováno v:
Toxicology and Applied Pharmacology. 103:288-302
Toxic cardiovascular effects of allylamine and beta-aminopropionitrile were studied in adult male Sprague-Dawley rats given allylamine alone (AA), 100 mg/kg/day, beta-aminopropionitrile alone (beta APN), 1 g/kg/day, or both chemicals (AA + beta APN)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9a5438a708849d01a786c3b426b4b86
https://doi.org/10.1016/0041-008x(90)90231-i
https://doi.org/10.1016/0041-008x(90)90231-i
Publikováno v:
Circulation research. 66(1)
Although it has long been thought that environmental toxins may play an underlying role in vascular diseases such as atherosclerosis, this concept is not supported by any clear-cut experimental evidence of toxic metabolism by cardiovascular enzymes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7996293725a411bea822181a6879ee21
https://pubmed.ncbi.nlm.nih.gov/2104785
https://pubmed.ncbi.nlm.nih.gov/2104785
Autor:
Robert M. Hysmith, Paul J. Boor
Publikováno v:
Toxicology. 44:129-145
The chemistry, industrial usage, general toxicity, and experimental use of allylamine are briefly reviewed. This highly reactive unsaturated alkylamine has had industrial applications in a variety of organic processes, and continues to be utilized, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8556a8a478606983cf60b5023a1714ae
https://doi.org/10.1016/0300-483x(87)90144-2
https://doi.org/10.1016/0300-483x(87)90144-2
Autor:
Richard C. Franson, Robert M. Hysmith
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 712:698-701
Cell-free media from cultures of virulent Naegleria fowleri were tested for phospholipase activities and their ability to degrade phospholipids of human myelin. Virulent N. fowleri selectively released lipolytic enzymes into the media at various time
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8be4cd329dc47e8f390d4674c34d111e
https://doi.org/10.1016/0005-2760(82)90300-9
https://doi.org/10.1016/0005-2760(82)90300-9
Autor:
Robert M. Hysmith, Paul J. Boor
Publikováno v:
Toxicology. 51:133-145
In this study we demonstrate that by inhibiting benzylamine oxidase (BzAO) with either semicarbazide or phenelzine, aortic smooth muscle cells (ASMCs) are protected from cytolethal injury by the cardiovascular toxin allylamine. We find that although
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d56efacaf716718069ea81065e2c19e
https://doi.org/10.1016/0300-483x(88)90144-8
https://doi.org/10.1016/0300-483x(88)90144-8
Autor:
Paul J. Boor, Robert M. Hysmith
Publikováno v:
Journal of Cardiovascular Pharmacology. 9:668-674
Benzylamine oxidase (BzAO) activity was measured in cultured smooth muscle and endothelial cells derived from thoracic aorta of adult swine, and in homogenates of dissected aortic medial and intimal layers. BzAO appeared to be localized in aortic med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::178c392013a7270d499547a06efdb726
https://doi.org/10.1097/00005344-198706000-00005
https://doi.org/10.1097/00005344-198706000-00005
Publikováno v:
Pharmacological Research Communications. 20:173-175
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dacff7572c25640bce743e1fea63093c
https://doi.org/10.1016/s0031-6989(88)80594-0
https://doi.org/10.1016/s0031-6989(88)80594-0
Autor:
Paul J. Boor, Robert M. Hysmith
Publikováno v:
Toxicology. 35(3)
The cardiovascular toxin allylamine (3-aminopropene) has been shown to concentrate in elastic and muscular tissues. In this study the 14C-moiety of [14C]allylamine was traced in aortas of adult Sprague-Dawley rats after intravenously injecting 30 mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2a048bb99a973e28da3a45690ef8d4a
https://pubmed.ncbi.nlm.nih.gov/2990070
https://pubmed.ncbi.nlm.nih.gov/2990070
Autor:
Robert M. Hysmith, Richard C. Franson
Publikováno v:
Biochimica et biophysica acta. 711(1)
Phospholipase A, sphingomyelinase and lysophospholipase activities were examined in cell homogenates and cell-free culture media of virulent and virulent-attenuated Naegleria fowleri and nonpathogenic Naegleria gruberi. Homogenates of virulent N. fow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bb364da998d6b17e8bb8ce3c7983ee9
https://pubmed.ncbi.nlm.nih.gov/6279166
https://pubmed.ncbi.nlm.nih.gov/6279166
Autor:
Paul J. Boor, Robert M. Hysmith
Publikováno v:
Toxicology. 44(1)
This study demonstrates specific and saturable binding of [14C] allylamine to mitochondria derived from rat aorta and heart. Specific binding is linear with respect to mitochondrial concentration and has a pH optimum of 7.0. Saturation isotherms reve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aa7ba7e9cdadce0fec640a7a9541cd8
https://pubmed.ncbi.nlm.nih.gov/3105119
https://pubmed.ncbi.nlm.nih.gov/3105119