Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Robert M. DiFazio"'
Publikováno v:
Genome Medicine, Vol 10, Iss 1, Pp 1-14 (2018)
Abstract There are fundamental differences between humans and the animals we typically use to study the immune system. We have learned much from genetically manipulated and inbred animal models, but instances in which these findings have been success
Externí odkaz:
https://doaj.org/article/12080ad3f917400ca9fd44b9f26bc628
Autor:
Louis R. Joslyn, Elsje Pienaar, Robert M. DiFazio, Sara Suliman, Benjamin M. Kagina, JoAnne L. Flynn, Thomas J. Scriba, Jennifer J. Linderman, Denise E. Kirschner
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Tuberculosis (TB) is the leading cause of death by an infectious agent, and developing an effective vaccine is an important component of the WHO's EndTB Strategy. Non-human primate (NHP) models of vaccination are crucial to TB vaccine development and
Externí odkaz:
https://doaj.org/article/21bb1f183e814d17bd59eefb8efaf249
Autor:
Anthony M Cadena, Forrest F Hopkins, Pauline Maiello, Allison F Carey, Eileen A Wong, Constance J Martin, Hannah P Gideon, Robert M DiFazio, Peter Andersen, Philana Ling Lin, Sarah M Fortune, JoAnne L Flynn
Publikováno v:
PLoS Pathogens, Vol 14, Iss 10, p e1007305 (2018)
For many pathogens, including most targets of effective vaccines, infection elicits an immune response that confers significant protection against reinfection. There has been significant debate as to whether natural Mycobacterium tuberculosis (Mtb) i
Externí odkaz:
https://doaj.org/article/ad202065f80e48eeae2994517ddee81a
Autor:
Philana Ling Lin, Pauline Maiello, Hannah P Gideon, M Teresa Coleman, Anthony M Cadena, Mark A Rodgers, Robert Gregg, Melanie O'Malley, Jaime Tomko, Daniel Fillmore, L James Frye, Tara Rutledge, Robert M DiFazio, Christopher Janssen, Edwin Klein, Peter L Andersen, Sarah M Fortune, JoAnne L Flynn
Publikováno v:
PLoS Pathogens, Vol 12, Iss 7, p e1005739 (2016)
Mycobacterium tuberculosis infection presents across a spectrum in humans, from latent infection to active tuberculosis. Among those with latent tuberculosis, it is now recognized that there is also a spectrum of infection and this likely contributes
Externí odkaz:
https://doaj.org/article/618e2e8d7ad5407fae0a0f8a69153c72
Autor:
Charles A. Scanga, Mario Roederer, JoAnne L. Flynn, Mark Rodgers, Pauline Maiello, Joshua A Hackney, Thomas Lindenstrøm, Amy J. Myers, Victor Prikhodko, Dominick Laddy, Hannah P. Gideon, Patricia A. Darrah, Philana Ling Lin, Robert M. DiFazio, Peter Andersen, Thomas J. Evans, Robert A. Seder
Publikováno v:
npj Vaccines, Vol 4, Iss 1, Pp 1-13 (2019)
NPJ Vaccines
NPJ Vaccines
Tuberculosis (TB) is the leading cause of death from infection worldwide. The only approved vaccine, BCG, has variable protective efficacy against pulmonary TB, the transmissible form of the disease. Therefore, improving this efficacy is an urgent pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c14d05fe7be948a2ee6ac0dcb6fc9e5
http://link.springer.com/article/10.1038/s41541-019-0113-9
http://link.springer.com/article/10.1038/s41541-019-0113-9
Publikováno v:
Genome Medicine, Vol 10, Iss 1, Pp 1-14 (2018)
Genome Medicine
Genome Medicine
There are fundamental differences between humans and the animals we typically use to study the immune system. We have learned much from genetically manipulated and inbred animal models, but instances in which these findings have been successfully tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5141f400929b1107aa1d4952d1628ea
http://link.springer.com/article/10.1186/s13073-018-0584-8
http://link.springer.com/article/10.1186/s13073-018-0584-8
Autor:
Jennifer J. Linderman, Hayley Warsinske, Denise E. Kirschner, JoAnne L. Flynn, Robert M. DiFazio
Publikováno v:
Journal of Theoretical Biology. 429:1-17
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is a pulmonary pathogen of major global concern. A key feature of Mtb infection in primates is the formation of granulomas, dense cellular structures surrounding infected lun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::177c5b663e559e3c517715fc9703522b
https://doi.org/10.1016/j.jtbi.2017.06.017
https://doi.org/10.1016/j.jtbi.2017.06.017
Autor:
Mark M. Davis, Robert M. DiFazio
Publikováno v:
Curious2018 ISBN: 9783030160609
The field of immunology is undergoing a seismic shift, from a predominant focus on inbred mice, and relatively poorly predictive models of human diseases, to new paradigms and methods to analyze human diseases directly. Thus, it should become a much
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a38b36fde455b969cea1301696b5708
https://doi.org/10.1007/978-3-030-16061-6_6
https://doi.org/10.1007/978-3-030-16061-6_6
Autor:
JoAnne L. Flynn, Constance J. Martin, Sarah M. Fortune, Allison F. Carey, Eileen A. Wong, Anthony M. Cadena, Pauline Maiello, Philana Ling Lin, Forrest F. Hopkins, Hannah P. Gideon, Peter Andersen, Robert M. DiFazio
Publikováno v:
PLoS Pathogens, Vol 14, Iss 10, p e1007305 (2018)
PLoS Pathogens
PLoS Pathogens
For many pathogens, including most targets of effective vaccines, infection elicits an immune response that confers significant protection against reinfection. There has been significant debate as to whether natural Mycobacterium tuberculosis (Mtb) i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca3e82c2fb67ad5580b2650d5fb2947d
https://doaj.org/article/ad202065f80e48eeae2994517ddee81a
https://doaj.org/article/ad202065f80e48eeae2994517ddee81a
Autor:
Mark Rodgers, Pauline Maiello, Charles A. Scanga, JoAnne L. Flynn, Philana Ling Lin, Anthony M. Cadena, Robert M. DiFazio
In the past 2 decades, it has become increasingly clear that nonhuman primates, specifically macaques, are useful models for human tuberculosis (TB). Several macaque species have been used for TB studies, and questions remain about the similarities a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caa8984b6ceda4debabae1c0d51cc58a
https://europepmc.org/articles/PMC5778369/
https://europepmc.org/articles/PMC5778369/