Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Robert M. Brucklacher"'
Autor:
Colleen A. Mangold, Benjamin Wronowski, Mei Du, Dustin R. Masser, Niran Hadad, Georgina V. Bixler, Robert M. Brucklacher, Matthew M. Ford, William E. Sonntag, Willard M. Freeman
Publikováno v:
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-19 (2017)
Abstract Background The necessity of including both males and females in molecular neuroscience research is now well understood. However, there is relatively limited basic biological data on brain sex differences across the lifespan despite the diffe
Externí odkaz:
https://doaj.org/article/8ff50482fdfc4d15be815b02c6ed9c50
Autor:
Gregory J. Berry, Christine Frielle, Robert M. Brucklacher, Anna C. Salzberg, Hanspeter Waldner
Publikováno v:
Genomics Data, Vol 5, Iss C, Pp 184-188 (2015)
Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease resulting from the destruction of insulin-producing pancreatic beta cells and is fatal unless treated with insulin. During the last four decades, multiple insulin-dependent diabetes (Idd)
Externí odkaz:
https://doaj.org/article/8c1287ec644a4d0983fd2fee182a9983
Autor:
Robert M. Brucklacher, Anna C. Salzberg, Conroy Ej, Yuka Imamura Kawasawa, Jiafen Hu, Bixler Gv, Nancy M. Cladel
Best practices to handling duplicated mapped reads in RNA-seq analyses has long been discussed but a gold standard method has yet to be established, as such duplicates could originate from valid biological transcripts or they could be PCR-related art
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36bfaec9698fe4539b180ce687f80711
https://doi.org/10.1101/301259
https://doi.org/10.1101/301259
Autor:
Georgina V. Bixler, Jonathan D. Wren, Han Yan, Willard M. Freeman, Cory B. Giles, William E. Sonntag, Dustin R. Masser, Robert M. Brucklacher
Publikováno v:
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 69:1311-1324
Impairment of hippocampal-dependent spatial learning and memory with aging affects a large segment of the aged population. Hippocampal subregions (CA1, CA3, and DG) have been previously reported to express both common and specific morphological, func
Autor:
Marek Postuła, Tadahiro Uemura, Gregory E. R. Weller, Bruce D. Spiess, Piotr K. Janicki, Saifeldin Ahmed Mahmoud, Saravanan Ramamoorthy, Willard M. Freeman, Haresh Mani, Zakiyah Kadry, Berend Mets, Robert M. Brucklacher, Dmitri Bezinover
Publikováno v:
Journal of Surgical Research. 188:517-526
Background Effects of two perfluorocarbon (PFC) formulations (perfluorodecalin emulsion and perfluorodecalin liquid) on the quality of liver graft preservation, in a donation after cardiac death (DCD) rat model, were investigated. The significance of
Autor:
Matthew M. Ford, Niran Hadad, Colleen A. Mangold, Mei Rong Du, Benjamin Wronowski, William E. Sonntag, Dustin R. Masser, Willard M. Freeman, Robert M. Brucklacher, Georgina V. Bixler
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-19 (2017)
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-19 (2017)
Background The necessity of including both males and females in molecular neuroscience research is now well understood. However, there is relatively limited basic biological data on brain sex differences across the lifespan despite the differences in
Autor:
Alistair J. Barber, Heather D. VanGuilder, Thomas W. Gardner, Kruti M. Patel, Robert M. Brucklacher, Sarah K. Bronson, Kathryn F. LaNoue, Scot R. Kimball, Willard M. Freeman, Cheng-mao Lin, David A. Antonetti, Georgina V. Bixler
Publikováno v:
The Pharmacogenomics Journal. 10:385-395
Biomarkers that can be measured in preclinical models in a high-throughput, reproducible manner offer the potential to increase the speed and efficacy of drug development. Development of therapeutic agents for many conditions is hampered by the limit
Autor:
Erin Walsh, Scot R. Kimball, Sarah K. Bronson, Georgina V. Bixler, Robert M. Brucklacher, Willard M. Freeman, Leonard S. Jefferson
Publikováno v:
Journal of Ocular Biology, Diseases, and Informatics
Mouse models of type I diabetes offer the potential to combine genetic approaches with other pharmacological or physiological manipulations to investigate the pathophysiology and treatment of diabetic retinopathy. Type I diabetes is induced in mice t
Autor:
Rhona W. Ellis, Willard M. Freeman, Robert M. Brucklacher, Kruti M. Patel, Heather D. VanGuilder, Alistair J. Barber
Publikováno v:
European Journal of Neuroscience. 28:1-11
Diabetic retinopathy can result in vision loss and involves progressive neurovascular degeneration of the retina. This study tested the hypothesis that diabetes decreases the retinal expression of presynaptic proteins involved in synaptic function. T
Autor:
Drake Morgan, Mandi S. Erwin, Kruti M. Patel, David C.S. Roberts, Robert M. Brucklacher, Malinda E Lull, Kent E. Vrana, Willard M. Freeman
Publikováno v:
Neuropsychopharmacology. 33:1807-1817
Cocaine-responsive gene expression changes have been described after either no drug abstinence or short periods of abstinence. Little data exist on the persistence of these changes after long-term abstinence. Previously, we reported that after discre