Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Robert M. Bare"'
Autor:
Akira Masuda, W Gregory Alvord, Ailian Zhao, Lucy M. Anderson, Kazimierz S. Kasprzak, Takashi Takahashi, Robert Y.S. Cheng, Robert M. Bare, Douglas A Powell
Publikováno v:
Toxicology and Applied Pharmacology. 191:22-39
Occupational exposure to nickel compounds is associated with lung cancer risk; both genotoxic and epigenetic mechanisms have been proposed. For comprehensive examination of the acute effects of nickel(II) acetate on gene expression in cultured human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6fd914e8f4dc0c2ee497f8ecf5f0e6e
https://doi.org/10.1016/s0041-008x(03)00228-x
https://doi.org/10.1016/s0041-008x(03)00228-x
Publikováno v:
Toxicology. 117:99-109
Cadmium (Cd) is carcinogenic in humans and laboratory animals. Depending on the duration and route of exposure, Cd can also induce damage in the liver, kidneys and lungs. In certain tissues, metallothionein (MT) proteins are induced by Cd exposure an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ac3a22071ea0340283b1cdf59526337
https://doi.org/10.1016/s0300-483x(96)03557-3
https://doi.org/10.1016/s0300-483x(96)03557-3
Publikováno v:
Toxicology. 107:121-130
The rodent testes are generally more susceptible to cadmium (Cd)-induced toxicity than the liver. Cd induces predominantly testicular interstitial cell (TIC) tumors. In order to clarify the molecular mechanism underlying tissue differences in Cd sens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bf8789608cc15718db20d0593369149
https://doi.org/10.1016/0300-483x(95)03252-b
https://doi.org/10.1016/0300-483x(95)03252-b
Publikováno v:
Journal of Toxicology and Environmental Health. 41:233-245
Metallothioneins (MTs) are low-molecular-weight, cysteine-rich proteins that appear to play an important role in the cellular defense system against cadmium toxicity. Although substantial evidence exists demonstrating a reduction in cadmium toxicity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f82d5303d805868ea895cd7cddcb519f
https://doi.org/10.1080/15287399409531839
https://doi.org/10.1080/15287399409531839
Autor:
Jerry M. Rice, Jerrold M. Ward, Christopher M. Weghorst, Bhalchandra A. Diwan, Michael P. Waalkes, Robert M. Bare
Publikováno v:
Toxicology and Applied Pharmacology. 110:327-335
The B6C3F1 mouse liver has been widely used for the evaluation of carcinogenic or tumor promoting efficacy of various organic compounds, although little is known about the actions of metallic carcinogens in this system. Thus, the ability of cadmium t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b31c02eaec698038e97ce86a1a73f20a
https://doi.org/10.1016/s0041-008x(05)80015-8
https://doi.org/10.1016/s0041-008x(05)80015-8
Autor:
Kazimierz S. Kasprzak, Bhalchandra A. Diwan, Michael P. Waalkes, Robert M. Bare, Renata Kowara, Konstantin Salnikow
Publikováno v:
Molecular and cellular biochemistry. 255(1-2)
Nickel compounds are carcinogenic and induce malignant transformation of cultured cells. Since nickel has low mutagenic potential, it may act predominantly through epigenetic mechanisms, including down-regulation of tumor suppressor genes. FHIT is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a694f8f49c6f2a181f759c8783f22aa6
https://pubmed.ncbi.nlm.nih.gov/14971660
https://pubmed.ncbi.nlm.nih.gov/14971660
Autor:
Wojciech Bal, Robert M. Bare, Kazimierz S. Kasprzak, Van M. Hoang, Susan L. North, Aldona A. Karaczyn, Robert J. Fisher
Publikováno v:
Chemical research in toxicology. 16(12)
We have demonstrated previously that Ni(II) binds to the C-terminal -TESHHKAKGK motif of isolated bovine histone H2A. At physiological pH, the bound Ni(II) assists in hydrolysis of the E-S peptide bond in this motif that results in a cleavage of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f6107cb14efd020c9a523e3537ab8d0
https://pubmed.ncbi.nlm.nih.gov/14680369
https://pubmed.ncbi.nlm.nih.gov/14680369
Publikováno v:
Toxicology. 116(1-3)
Previous work has indicated that testosterone pretreatment protects against cadmium-induced toxicity in male rats while other data indicate that pretreatment of mice with testosterone offers no such protection against cadmium. Since cadmium toxicity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc74df980ab1862481c1177783a92952
https://pubmed.ncbi.nlm.nih.gov/9020520
https://pubmed.ncbi.nlm.nih.gov/9020520
Publikováno v:
Toxicology and applied pharmacology. 113(2)
It is well established that zinc can decrease the carcinogenicity and toxicity of cadmium. In some tissues this may be due to the induction of metallothionein (MT). Therefore, in the present investigation, the effect of zinc pretreatment on cadmium-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02053918f1e4d4711f679f98e713a54e
https://pubmed.ncbi.nlm.nih.gov/1561631
https://pubmed.ncbi.nlm.nih.gov/1561631
Autor:
Renata Kowara, Konstantin Salnikow, Bhalchandra A. Diwan, Robert M. Bare, Michael P. Waalkes, Kazimierz S. Kasprzak
Publikováno v:
Molecular & Cellular Biochemistry; Jan2004, Vol. 255 Issue 1, p195-202, 8p