Zobrazeno 1 - 10
of 306
pro vyhledávání: '"Robert M. Adlington"'
Autor:
Adrian W. Markwell-Heys, Michelle C. Cruickshank, Robert M. Adlington, K. Kuan, Jack E. Baldwin, Denise P. Tran, Jonathan H. George
Publikováno v:
Bioorganic & Medicinal Chemistry. 27:2449-2465
The marine sponge Aka coralliphaga is a rich source of biologically active and structurally interesting meroterpenoids. Inspired by these natural products, we have used biosynthetic speculation to devise biomimetic syntheses of siphonodictyal B, liph
Publikováno v:
SYNLETT. 29(8)
The synthesis of various epimers of the lindenane class of sesquiterpenes from epi-lindenene, based on a possible biosynthetic hypothesis, is described.
Publikováno v:
FEBS Letters. 587:2705-2709
Isopenicillin N synthase (IPNS) is a non-heme iron oxidase central to the biosynthesis of β-lactam antibiotics. IPNS converts the tripeptide δ-(l-α-aminoadipoyl)-l-cysteinyl-d-valine (ACV) to isopenicillin N while reducing molecular oxygen to wate
Autor:
Andy Lawrence, Jessica A. Kershaw, Jack E. Baldwin, Amber L. Thompson, Victor Lee, Robert M. Adlington
The biosynthesis of the meroterpenoid guajadial was previously hypothesized to occur via a hetero-Diels-Alder reaction between caryophyllene and an o-quinone methide. This hypothesis has been verified via the biomimetic synthesis of guajadial and psi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d2a8efbd609545563d840f65110ea35
https://ora.ox.ac.uk/objects/uuid:e28e0313-e6d1-483b-9547-d673ea22addc
https://ora.ox.ac.uk/objects/uuid:e28e0313-e6d1-483b-9547-d673ea22addc
α-Amido trifluoromethyl alcohols and ketones were synthesised via two independent routes using the Ruppert Reagent (TMS-CF 3 ) and shown to be inhibitors of metallo-β-lactamases.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27090b4c6262da94efa82238abacde2b
https://ora.ox.ac.uk/objects/uuid:b20952f2-511c-4030-b416-f10fe2ef6d8a
https://ora.ox.ac.uk/objects/uuid:b20952f2-511c-4030-b416-f10fe2ef6d8a
Autor:
Robert Cassels, Jack E. Baldwin, Christopher J. Schofield, Timothy J. Sewell, Matthew D. Lloyd, Robert M. Adlington, Justin S. Bryans, Keith H. Baggaley
Incubation of the γ-lactam analogue of proclavaminic acid, (±)-threo-5-amino-3-hydroxy-2-(1′-aza-2′-oxocyclopentyl)-pentanoic acid, led to production of two bicyclic γ-lactam products.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa46150eee1df003045013821443d025
https://doi.org/10.1016/s0040-4020(97)00399-2
https://doi.org/10.1016/s0040-4020(97)00399-2
Studies towards the synthesis of coprinolone, Δ6- coprinolone, and radulone A, resulting in the synthesis of an advanced intermediate with the tricyclic protoilludane carbon skeleton, are described. © Georg Thieme Verlag Stuttgart.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6412dfcfc50c8b792705038055958d90
https://doi.org/10.1055/s-2008-1078569
https://doi.org/10.1055/s-2008-1078569
Autor:
Robert A. Field, Niamh M. O'callaghan, Juliette W. Bird, Jack E. Baldwin, Robert M. Adlington, Christopher J. Schofield
Incorporation of [4-2H6,18O2]-valine into δ-(L)-α-aminoadipoyl)-L-cysteinyl-D-valine (ACV), by intact cells of Cephalosporium acremonium, demonstrated the intracellular exchange of one and both valine oxygen atoms. Incubation of [18O2]-valine with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa8734de98999a44421d14ef090c2e05
https://ora.ox.ac.uk/objects/uuid:e94d4da9-1e79-46ff-82ba-19db925e94e6
https://ora.ox.ac.uk/objects/uuid:e94d4da9-1e79-46ff-82ba-19db925e94e6
Autor:
Nicholas P. Crouch, Jack E. Baldwin, Robert M. Adlington, Hong-Hoi Ting, Christopher J. Schofield
Cell-free preparations of the deacetoxycephalosporin C/deacetylcephalosporin C synthetase activities from Cephalosporium acremonium CO 728 were shown to convert the unnatural substrate methylenecephalosporin C (1) in the presence of 18O2, into [hydro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::169d6704f7ac630784f05fc460fd0812
https://doi.org/10.1039/c39870001556
https://doi.org/10.1039/c39870001556
A free radical mediated ring expansion of cis - and trans - α-alkylated-β-stannylcyclohexanones to provide efficient routes to cis - and trans -cyclononenones and cyclodecenones is described. The cis-/trans - relationship in the precursor was found
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e66052b374052d0dbd31bfecd36683d7
https://doi.org/10.1016/0040-4020(89)80003-1
https://doi.org/10.1016/0040-4020(89)80003-1