Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Robert M Schilke"'
Autor:
Kasopefoluwa Y. Oguntuyo, Christian S. Stevens, Chuan Tien Hung, Satoshi Ikegame, Joshua A. Acklin, Shreyas S. Kowdle, Jillian C. Carmichael, Hsin-Ping Chiu, Kristopher D. Azarm, Griffin D. Haas, Fatima Amanat, Jéromine Klingler, Ian Baine, Suzanne Arinsburg, Juan C. Bandres, Mohammed N. A. Siddiquey, Robert M. Schilke, Matthew D. Woolard, Hongbo Zhang, Andrew J. Duty, Thomas A. Kraus, Thomas M. Moran, Domenico Tortorella, Jean K. Lim, Andrea V. Gamarnik, Catarina E. Hioe, Susan Zolla-Pazner, Stanimir S. Ivanov, Jeremy P. Kamil, Florian Krammer, Benhur Lee
Publikováno v:
mBio, Vol 12, Iss 1 (2021)
Vaccines and antibody-based therapeutics like convalescent-phase plasma therapy are premised upon inducing or transferring neutralizing antibodies that inhibit SARS-CoV-2 entry into cells. Virus neutralization assays (VNAs) for measuring neutralizing
Externí odkaz:
https://doaj.org/article/9f425d57749f4d2aabcd8c8d41ea0f24
Autor:
Sunitha Chandran, Robert M. Schilke, Cassidy M. R. Blackburn, Aila Yurochko, Rusella Mirza, Rona S. Scott, Brian N. Finck, Matthew D. Woolard
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Macrophage responses contribute to a diverse array of pathologies ranging from infectious disease to sterile inflammation. Polarization of macrophages determines their cellular function within biological processes. Lipin-1 is a phosphatidic acid phos
Externí odkaz:
https://doaj.org/article/2f929f1134fb4913933bcb98fe4f56da
Publikováno v:
Biomolecules, Vol 10, Iss 10, p 1449 (2020)
Phospholipases are a family of lipid-altering enzymes that can either reduce or increase bioactive lipid levels. Bioactive lipids elicit signaling responses, activate transcription factors, promote G-coupled-protein activity, and modulate membrane fl
Externí odkaz:
https://doaj.org/article/fc85c8caa60e4845bbc27b606b4b562c
Autor:
David M. Krzywanski, Shashanka Rao, Matthew D. Woolard, Brian N. Finck, Cassidy M.R. Blackburn, Robert M. Schilke
Publikováno v:
ImmunoHorizons
Macrophages reprogram their metabolism to promote appropriate responses. Proresolving macrophages primarily use fatty acid oxidation as an energy source. Metabolites generated during the catabolism of fatty acids aid in the resolution of inflammation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::041834b53898fd6de205fceb2d32c409
http://europepmc.org/articles/PMC7739271
http://europepmc.org/articles/PMC7739271
Lipin-1 restrains lipid synthesis to promote proresolving macrophage function and disease resolution
Publikováno v:
The Journal of Immunology. 208:54.23-54.23
Macrophages are critical to maintaining and restoring tissue homeostasis during inflammation. Unresolved inflammation contributes to the pathophysiology of cardiometabolic diseases. The lipid metabolic state of macrophages influences their function.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7a4bfd92c512b1a9453be4b958679bf
https://doi.org/10.4049/jimmunol.208.supp.54.23
https://doi.org/10.4049/jimmunol.208.supp.54.23
Publikováno v:
Biomolecules
Biomolecules, Vol 10, Iss 1449, p 1449 (2020)
Biomolecules, Vol 10, Iss 1449, p 1449 (2020)
Phospholipases are a family of lipid-altering enzymes that can either reduce or increase bioactive lipid levels. Bioactive lipids elicit signaling responses, activate transcription factors, promote G-coupled-protein activity, and modulate membrane fl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7341f461f7f5ad833356b20934476f05
Autor:
Kasopefoluwa Y, Oguntuyo, Christian S, Stevens, Mohammed Na, Siddiquey, Robert M, Schilke, Matthew D, Woolard, Hongbo, Zhang, Joshua A, Acklin, Satoshi, Ikegame, Chuan-Tien, Hung, Jean K, Lim, Robert W, Cross, Thomas W, Geisbert, Stanimir S, Ivanov, Jeremy P, Kamil, Benhur, Lee
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
Entry of SARS-CoV-2 is facilitated by endogenous and exogenous proteases. These proteases proteolytically activate the SARS-CoV-2 spike glycoprotein and are key modulators of virus tropism. We show that SARS-CoV-2 naïve serum exhibits significant in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::20367422ed176169f0d207b65a31d4b4
https://pubmed.ncbi.nlm.nih.gov/32817940
https://pubmed.ncbi.nlm.nih.gov/32817940
Autor:
Thomas W. Geisbert, Stanimir S. Ivanov, Hongbo Zhang, Robert M. Schilke, Christian S. Stevens, Joshua A. Acklin, Satoshi Ikegame, Benhur Lee, Kasopefoluwa Y. Oguntuyo, Jean K. Lim, Jeremy P. Kamil, Mohammed N. A. Siddiquey, Chuan Tien Huang, Robert W. Cross, Matthew D. Woolard
RationaleSARS-CoV-2 entry into host cells is facilitated by endogenous and exogenous proteases that proteolytically activate the spike glycoprotein and antiproteases inhibiting this process. Understanding the key actors in viral entry is crucial for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdaf897cdb0042653107c5bbf901020b
https://doi.org/10.1101/2020.08.14.248880
https://doi.org/10.1101/2020.08.14.248880
Autor:
Brian N. Finck, Shashanka Rao, David Krzywanski, Robert M Schilke, Cassidy M.R. Blackburn, Matthew D. Woolard
Macrophages reprogram their metabolism to promote appropriate responses. Pro-resolving macrophages primarily utilize fatty acid oxidation as an energy source. Metabolites generated during the catabolism of fatty acids aid in the resolution of inflamm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::498ef62330a9349110cbd94b3ce467be
https://doi.org/10.1101/2020.06.03.121293
https://doi.org/10.1101/2020.06.03.121293
Autor:
Robert M Schilke, Matthew D. Woolard, Cassidy M.R. Blackburn, Aimee E. Vozenilek, Brian N. Finck
During atherosclerosis, macrophages engulf and break down deposited modified low-density lipoproteins (modLDLs) into lipids and free fatty acids. The lipids and free fatty acids from these modLDLs either need to be stored during a process called glyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8596db3eda6d771aa7c87eb68846f42
https://doi.org/10.1101/2020.06.02.130096
https://doi.org/10.1101/2020.06.02.130096