Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Robert M Q, Shanks"'
Autor:
Robert M. Q. Shanks, Eric G. Romanowski, John E. Romanowski, Katherine Davoli, Nancy A. McNamara, Jes K. Klarlund
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-8 (2023)
Abstract Biologics are almost exclusively administered systemically, but localized delivery is preferable as it minimizes off-target exposure and allows more aggressive treatments. Topical application of biologics to epithelia is generally ineffectiv
Externí odkaz:
https://doaj.org/article/e531d3377b2743a18c3e0c7a3f926b03
Autor:
Robert M. Q. Shanks, Sarah Atta, Nicholas A. Stella, Chollapadi V. Sundar-Raj, John E. Romanowski, Arman S. Grewal, Hazel Q. Shanks, Sonya M. Mumper, Deepinder K. Dhaliwal, Alex Mammen, Jake D. Callaghan, Rachel C. Calvario, Eric G. Romanowski, Regis P. Kowalski, Michael E. Zegans, Vishal Jhanji
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
IntroductionPseudomonas aeruginosa causes vision threatening keratitis. The LasR transcription factor regulates virulence factors in response to the quorum sensing molecule N-3-oxo-dodecanoyl-L-homoserine lactone. P. aeruginosa isolates with lasR mut
Externí odkaz:
https://doaj.org/article/8ec495ac464e460e8c137979a0a63935
Autor:
Nathaniel S. Harshaw, Mitchell D. Meyer, Nicholas A. Stella, Kara M. Lehner, Regis P. Kowalski, Robert M. Q. Shanks
Publikováno v:
mSphere, Vol 8, Iss 1 (2023)
ABSTRACT The Enterobacterial Rcs stress response system reacts to envelope stresses through a complex two-component phosphorelay system to regulate a variety of environmental response genes, such as capsular polysaccharide and flagella biosynthesis g
Externí odkaz:
https://doaj.org/article/3cecc05ef64f40a0af91b6ca977e23ea
Publikováno v:
BMC Ophthalmology, Vol 20, Iss 1, Pp 1-10 (2020)
Abstract Background The cellular process of autophagy is essential for maintaining the health of ocular tissue. Dysregulation of autophagy is associated with several ocular diseases including keratoconus and macular degeneration. It is known that aut
Externí odkaz:
https://doaj.org/article/397e994854b34052a1982b97e387828f
Autor:
Anthony J Galante, Brady C Pilsbury, Kathleen A Yates, Melbs LeMieux, Daniel J Bain, Robert M Q Shanks, Eric G Romanowski, Paul W Leu
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0270718 (2022)
Medical textiles are subject to particularly harsh disinfection procedures in healthcare settings where exposure risks are high. This work demonstrates a fabric treatment consisting of a reactive silver ink and low surface energy PDMS polymer that pr
Externí odkaz:
https://doaj.org/article/974be7b4e2cc4b20bb3d268edc2a9c2f
Autor:
Gayatri Shankar Chilambi, Hayley R Nordstrom, Daniel R Evans, Regis P Kowalski, Deepinder K Dhaliwal, Vishal Jhanji, Robert M Q Shanks, Daria Van Tyne
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0250084 (2021)
Enterococcus faecalis are hospital-associated opportunistic pathogens and also causative agents of post-operative endophthalmitis. Patients with enterococcal endophthalmitis often have poor visual outcomes, despite appropriate antibiotic therapy. Her
Externí odkaz:
https://doaj.org/article/ad63cc6a9a894420aa32d366690a4099
Autor:
Miles C. Duncan, John C. Forbes, Y Nguyen, Lauren M. Shull, Rebecca K. Gillette, David W. Lazinski, Afsar Ali, Robert M. Q. Shanks, Daniel E. Kadouri, Andrew Camilli
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Prey bacteria have evolved different strategies to counteract predation but the genetic basis remains unclear. Here, Duncan et al. identify key genes involved in Vibrio cholerae sensitivity to Bdellovibrio bacteriovorus predation, providing new insig
Externí odkaz:
https://doaj.org/article/9dd47cd48290412ab43fa62a59005ef4
Autor:
Dongzhu Ma, Jonathan B. Mandell, Niles P. Donegan, Ambrose L. Cheung, Wanyan Ma, Scott Rothenberger, Robert M. Q. Shanks, Anthony R. Richardson, Kenneth L. Urish
Publikováno v:
mBio, Vol 10, Iss 6 (2019)
ABSTRACT Staphylococcus aureus is the major organism responsible for surgical implant infections. Antimicrobial treatment of these infections often fails, leading to expensive surgical intervention and increased risk of mortality to the patient. The
Externí odkaz:
https://doaj.org/article/f0c9f228eed34dbda35ad3ab5c193533
Autor:
Jonathan B. Mandell, Berthony Deslouches, Ronald C. Montelaro, Robert M. Q. Shanks, Yohei Doi, Kenneth L. Urish
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract Antibiotics are unable to remove biofilms from surgical implants. This high antibiotic tolerance is related to bacterial persisters, a sub-population of bacteria phenotypically tolerant to antibiotics secondary to a reduced metabolic state.
Externí odkaz:
https://doaj.org/article/cb3d0718c264403fae93484e9e97d3c0
Autor:
Nathaniel S. Harshaw, Nicholas A. Stella, Kara M. Lehner, Eric G. Romanowski, Regis P. Kowalski, Robert M. Q. Shanks
Publikováno v:
Antibiotics, Vol 10, Iss 9, p 1033 (2021)
The Rcs phosphorelay is a bacterial stress response system that responds to envelope stresses and in turn controls several virulence-associated pathways, including capsule, flagella, and toxin biosynthesis, of numerous bacterial species. The Rcs syst
Externí odkaz:
https://doaj.org/article/edfa77668cfc4d45911baaaeec365449