Zobrazeno 1 - 10 of 208 pro vyhledávání: '"Robert M Prins"'
2
Akademický článek
Monitoring of regulatory T cell frequencies and expression of CTLA-4 on T cells, before and after DC vaccination, can predict survival in GBM patients.
Autor: Brendan Fong, Richard Jin, Xiaoyan Wang, Michael Safaee, Dominique N Lisiero, Isaac Yang, Gang Li, Linda M Liau, Robert M Prins
Publikováno v: PLoS ONE, Vol 7, Iss 4, p e32614 (2012)
Dendritic cell (DC) vaccines have recently emerged as an innovative therapeutic option for glioblastoma patients. To identify novel surrogates of anti-tumor immune responsiveness, we studied the dynamic expression of activation and inhibitory markers
Externí odkaz: https://doaj.org/article/553e5c7328174b9cadf971e979e08478
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3
Akademický článek
Neoadjuvant PD-1 blockade induces T cell and cDC1 activation but fails to overcome the immunosuppressive tumor associated macrophages in recurrent glioblastoma
Autor: Alexander H. Lee, Lu Sun, Aaron Y. Mochizuki, Jeremy G. Reynoso, Joey Orpilla, Frances Chow, Jenny C. Kienzler, Richard G. Everson, David A. Nathanson, Steven J. Bensinger, Linda M. Liau, Timothy Cloughesy, Willy Hugo, Robert M. Prins
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Immune-checkpoint blockade has shown limited benefits in patients with glioblastoma. To understand how the composition of the tumor immune microenvironment might limit clinical responses, here the authors present a high dimensional profiling of the i
Externí odkaz: https://doaj.org/article/bc4276916a1e42c19b71f6a03a3eba26
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4
Akademický článek
Resolution of tissue signatures of therapy response in patients with recurrent GBM treated with neoadjuvant anti-PD1
Autor: Yue Lu, Alphonsus H. C. Ng, Frances E. Chow, Richard G. Everson, Beth A. Helmink, Michael T. Tetzlaff, Rohit Thakur, Jennifer A. Wargo, Timothy F. Cloughesy, Robert M. Prins, James R. Heath
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The response to neoadjuvant immune checkpoint blockade (ICB) in patients with recurrent gliolastoma multiforme (GBM) has been challenging to interpret. Here the authors develop a tumor analysis framework that reveals molecular similarities between GB
Externí odkaz: https://doaj.org/article/da58c67153ba43c0bfe64ab0eaad9f67
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6
IRIS: Discovery of cancer immunotherapy targets arising from pre-mRNA alternative splicing
Autor: Yang Pan, John W. Phillips, Beatrice D. Zhang, Miyako Noguchi, Eric Kutschera, Jami McLaughlin, Pavlo A. Nesterenko, Zhiyuan Mao, Nathanael J. Bangayan, Robert Wang, Wendy Tran, Harry T. Yang, Yuanyuan Wang, Yang Xu, Matthew B. Obusan, Donghui Cheng, Alex H. Lee, Kathryn E. Kadash-Edmondson, Ameya Champhekar, Cristina Puig-Saus, Antoni Ribas, Robert M. Prins, Christopher S. Seet, Gay M. Crooks, Owen N. Witte, Yi Xing
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 120, iss 21
Alternative splicing (AS) is prevalent in cancer, generating an extensive but largely unexplored repertoire of novel immunotherapy targets. We describe I soform peptides from R NA splicing for I mmunotherapy target S creening (IRIS), a computational
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a93609197fd5c544787a244456cbfc71
https://doi.org/10.1073/pnas.2221116120
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