Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Robert M Krug"'
Autor:
Zhanwei Du, Lin Wang, Yuan Bai, Yunhu Liu, Eric HY Lau, Alison P Galvani, Robert M Krug, Benjamin John Cowling, Lauren A Meyers
Publikováno v:
eLife, Vol 13 (2024)
Paxlovid, a SARS-CoV-2 antiviral, not only prevents severe illness but also curtails viral shedding, lowering transmission risks from treated patients. By fitting a mathematical model of within-host Omicron viral dynamics to electronic health records
Externí odkaz:
https://doaj.org/article/5ad67f6f00484c62a3119e4465563afe
Autor:
Margery G Smelkinson, Annabel Guichard, John R Teijaro, Meghana Malur, Maria Eugenia Loureiro, Prashant Jain, Sundar Ganesan, Elina I Zúñiga, Robert M Krug, Michael B Oldstone, Ethan Bier
Publikováno v:
PLoS Pathogens, Vol 13, Iss 8, p e1006588 (2017)
The multifunctional NS1 protein of influenza A viruses suppresses host cellular defense mechanisms and subverts other cellular functions. We report here on a new role for NS1 in modifying cell-cell signaling via the Hedgehog (Hh) pathway. Genetic epi
Externí odkaz:
https://doaj.org/article/8296206c2f914e29bb8799c937494a0b
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
Considering the significant impact of the recent COVID-19 outbreak, development of broad-spectrum antivirals is a high priority goal to prevent future global pandemics. Antiviral development processes generally emphasize targeting a specific protein
Externí odkaz:
https://doaj.org/article/2650cc70537c4b1e9b4585923e0623e4
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-6 (2020)
Here, the authors implement a mathematical model that describes how Baloxavir antiviral-induced inhibition of influenza virus replication in infected individuals affects the spread of the virus during epidemics, suggesting that both the scaling up an
Externí odkaz:
https://doaj.org/article/fcf4d646137b4d9aa9dd957c0593cd7e
Autor:
Khushboo Bafna, Kris White, Balasubramanian Harish, Romel Rosales, Theresa A. Ramelot, Thomas B. Acton, Elena Moreno, Thomas Kehrer, Lisa Miorin, Catherine A. Royer, Adolfo García-Sastre, Robert M. Krug, Gaetano T. Montelione
Publikováno v:
Cell Reports, Vol 35, Iss 7, Pp 109133- (2021)
Summary: Effective control of COVID-19 requires antivirals directed against SARS-CoV-2. We assessed 10 hepatitis C virus (HCV) protease-inhibitor drugs as potential SARS-CoV-2 antivirals. There is a striking structural similarity of the substrate bin
Externí odkaz:
https://doaj.org/article/f487dc0be1e94d1382aa92c5a7ce55f1
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
The ubiquitin-like protein ISG15 can be covalently linked to cellular and viral proteins, but the consequences of this ‘ISGylation’ remain largely unknown. Here, Zhao et al.show that ISGylation of the influenza B virus nucleoprotein inhibits form
Externí odkaz:
https://doaj.org/article/43b757d7acbd47d3bdbf6796ccfb079c
Publikováno v:
mBio, Vol 9, Iss 4 (2018)
ABSTRACT Influenza A viruses cause an annual contagious respiratory disease in humans and are responsible for periodic high-mortality human pandemics. Pandemic influenza A viruses usually result from the reassortment of gene segments between human an
Externí odkaz:
https://doaj.org/article/16c486b3f1e04a7c9c1141fb0fa257e0
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-6 (2020)
Nature Communications
Nature Communications
Influenza viruses annually kill 290,000–650,000 people worldwide. Antivirals can reduce death tolls. Baloxavir, the recently approved influenza antiviral, inhibits initiation of viral mRNA synthesis, whereas oseltamivir, an older drug, inhibits rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e4cb5b97d400e3e905e452111f09e6f
https://doaj.org/article/fcf4d646137b4d9aa9dd957c0593cd7e
https://doaj.org/article/fcf4d646137b4d9aa9dd957c0593cd7e
Autor:
Gaetano T. Montelione, Ryan L Woltz, Emily M Grasso, Li-Chung Ma, Robert M. Krug, Guifang Chen, Shanshan Wang
Publikováno v:
Nucleic Acids Research
Influenza A viruses cause widespread human respiratory disease. The viral multifunctional NS1 protein inhibits host antiviral responses. This inhibition results from the binding of specific cellular antiviral proteins at various positions on the NS1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb8b17db867d16163af785a162662096
http://europepmc.org/articles/PMC6943125
http://europepmc.org/articles/PMC6943125
Autor:
Qiaozhen Ye, Tom S. Y. Guu, Douglas A. Mata, Rei-Lin Kuo, Bartram Smith, Robert M. Krug, Yizhi J. Tao
Publikováno v:
mBio, Vol 4, Iss 1 (2013)
ABSTRACT Influenza A virions contain eight ribonucleoproteins (RNPs), each comprised of a negative-strand viral RNA, the viral polymerase, and multiple nucleoproteins (NPs) that coat the viral RNA. NP oligomerization along the viral RNA is mediated l
Externí odkaz:
https://doaj.org/article/534c95a258664c50b972349353083cf5