Zobrazeno 1 - 10
of 451
pro vyhledávání: '"Robert M King"'
Autor:
Briana A. Santo, Shiau-Sing K. Ciecierska, S. Mostafa Mousavi Janbeh Sarayi, TaJania D. Jenkins, Ammad A. Baig, Andre Monteiro, Carmon Koenigsknecht, Donald Pionessa, Liza Gutierrez, Robert M. King, Matthew Gounis, Adnan H. Siddiqui, Vincent M. Tutino
Publikováno v:
Heliyon, Vol 9, Iss 4, Pp e14837- (2023)
Background: Infarct volume measured from 2,3,5-triphenyltetrazolium chloride (TTC)-stained brain slices is critical to in vivo stroke models. In this study, we developed an interactive, tunable, software that automatically computes whole-brain infarc
Externí odkaz:
https://doaj.org/article/3e4920b8dd1f48a5b4a6ad567eed20fa
Autor:
Toloo Taghian, Ana Rita Batista, Sarah Kamper, Michael Caldwell, Laura Lilley, Hao Li, Paola Rodriguez, Katerina Mesa, Shaokuan Zheng, Robert M. King, Matthew J. Gounis, Sophia Todeasa, Anne Maguire, Douglas R. Martin, Miguel Sena-Esteves, Thomas J. Meade, Heather L. Gray-Edwards
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss , Pp 128-134 (2021)
Transformative results of adeno-associated virus (AAV) gene therapy in patients with spinal muscular atrophy and Leber’s congenital amaurosis led to approval of the first two AAV products in the United States to treat these diseases. These extraord
Externí odkaz:
https://doaj.org/article/c16bf88485644845ad32d3c283989ad8
Autor:
Giovanni J. Ughi, Miklos G. Marosfoi, Robert M. King, Jildaz Caroff, Lindsy M. Peterson, Benjamin H. Duncan, Erin T. Langan, Amanda Collins, Anita Leporati, Serge Rousselle, Demetrius K. Lopes, Matthew J. Gounis, Ajit S. Puri
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
High resolution intravascular imaging in the brain is limited by the high tortuosity of the vasculature. Here the authors present a fiber optic imaging technology using high-frequency optical coherence tomography (HF-OCT) to provide volumetric high r
Externí odkaz:
https://doaj.org/article/1a31fc57ddd64468be33ef859daa291b
Autor:
Mark Epshtein, Moran Levi, Afif M. Kraitem, Hikaia Zidan, Robert M. King, Meinrad Gawaz, Matthew J. Gounis, Netanel Korin
Publikováno v:
Bioengineering & Translational Medicine, Vol 7, Iss 1, Pp n/a-n/a (2022)
Abstract Localized delivery of diagnostic/therapeutic agents to cerebral aneurysms, lesions in brain arteries, may offer a new treatment paradigm. Since aneurysm rupture leading to subarachnoid hemorrhage is a devastating medical emergency with high
Externí odkaz:
https://doaj.org/article/9c7033252d124074818211bd705aaa35
Autor:
Chantal M. Ferguson, Bruno M.D.C. Godinho, Julia F. Alterman, Andrew H. Coles, Matthew Hassler, Dimas Echeverria, James W. Gilbert, Emily G. Knox, Jillian Caiazzi, Reka A. Haraszti, Robert M. King, Toloo Taghian, Ajit Puri, Richard P. Moser, Matthew J. Gounis, Neil Aronin, Heather Gray-Edwards, Anastasia Khvorova
Publikováno v:
JCI Insight, Vol 6, Iss 24 (2021)
siRNAs comprise a class of drugs that can be programmed to silence any target gene. Chemical engineering efforts resulted in development of divalent siRNAs (di-siRNAs), which support robust and long-term efficacy in rodent and nonhuman primate brains
Externí odkaz:
https://doaj.org/article/6446b294c4ec4d69983aef3f4ec8e137
Autor:
Robert M. King, Matthew J. Gounis, Eric J. Schmidt, Anita Leporati, Eric M. Gale, Alexei A. Bogdanov
Publikováno v:
Investigative Radiology.
Autor:
Mohammed Salman Shazeeb, Robert M. King, Vania Anagnostakou, Zeynep Vardar, Afif Kraitem, Josephine Kolstad, Christopher Raskett, Natacha Le Moan, Jonathan A. Winger, Lauren Kelly, Ana Krtolica, Nils Henninger, Matthew J. Gounis
Publikováno v:
Stroke
Background: Tissue hypoxia plays a critical role in the events leading to cell death in ischemic stroke. Despite promising results in preclinical and small clinical pilot studies, inhaled oxygen supplementation has not translated to improved outcomes
Autor:
Vania Anagnostakou, Mark Epshtein, Giovanni J Ughi, Robert M King, Antonios Valavanis, Ajit S Puri, Matthew J Gounis
Publikováno v:
Journal of NeuroInterventional Surgery. 14:420-428
BackgroundThe micro-architectonics of the subarachnoid space (SAS) remain partially understood and largely ignored, likely the result of the inability to image these structures in vivo. We explored transvascular imaging with high-frequency optical co
Autor:
Hélène Tran, Michael P. Moazami, Huiya Yang, Diane McKenna-Yasek, Catherine L. Douthwright, Courtney Pinto, Jake Metterville, Minwook Shin, Nitasha Sanil, Craig Dooley, Ajit Puri, Alexandra Weiss, Nicholas Wightman, Heather Gray-Edwards, Miklos Marosfoi, Robert M. King, Thomas Kenderdine, Daniele Fabris, Robert Bowser, Jonathan K. Watts, Robert H. Brown
Publikováno v:
Nat Med
Expansions of a G(4)C(2) repeat in the C9ORF72 gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two devastating adult-onset neurodegenerative disorders. Using C9-ALS/FTD patient derived
Autor:
Laura M. Lilley, Sarah G. Kamper, Thomas J. Meade, Ana Rita Batista, Miguel Sena-Esteves, Hao Li, Matthew J. Gounis, Douglas R. Martin, Shaokuan Zheng, Katerina Mesa, Robert M. King, Paola Rodriguez, Toloo Taghian, Heather L. Gray-Edwards, Michael A. Caldwell, Anne S Maguire, Sophia H. Todeasa
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss, Pp 128-134 (2021)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Transformative results of adeno-associated virus (AAV) gene therapy in patients with spinal muscular atrophy and Leber’s congenital amaurosis led to approval of the first two AAV products in the United States to treat these diseases. These extraord