Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Robert Lodge"'
Autor:
Nicolas Bellini, Chengyu Ye, Oluwaseun Ajibola, Thomas T. Murooka, Robert Lodge, Éric A. Cohen
Publikováno v:
Viruses, Vol 16, Iss 7, p 1076 (2024)
MicroRNAs (miRNAs) play important roles in the control of HIV-1 infection. Here, we performed RNA-seq profiling of miRNAs and mRNAs expressed in CD4+ T lymphocytes upon HIV-1 infection. Our results reveal significant alterations in miRNA and mRNA exp
Externí odkaz:
https://doaj.org/article/98ea85c54eba4a34b070bb0e76291d42
Autor:
Robert Lodge, Zaikun Xu, Mckenna Eklund, Christina Stürzel, Frank Kirchhoff, Michel J. Tremblay, Tom C. Hobman, Éric A. Cohen
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT The type 1 interferon-regulated E3 ubiquitin ligase MARCH1 reduces surface expression of HIV-1 envelope glycoproteins (Env) and their packaging into nascent virions, a condition that restricts viral infectivity. However, how HIV-1 counters t
Externí odkaz:
https://doaj.org/article/d691c612579c4ccfb0b25dd7e74b1bb7
Autor:
Nicolas Bellini, Robert Lodge, Tram N.Q. Pham, Jaspreet Jain, Thomas T. Murooka, Alon Herschhorn, Nicole F. Bernard, Jean-Pierre Routy, Cécile L. Tremblay, Éric A. Cohen
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105234- (2022)
Summary: Activated-to-memory transitioning CD4+ T cells display elevated expression of the HIV-1 co-receptor CCR5 and are more prone to HIV-1 latent infection. Here, we show that p53-regulated miRNA-103 downmodulates CCR5 levels in CD4+ T lymphocytes
Externí odkaz:
https://doaj.org/article/30d4e7980f46475a9a5b3a72a2a0365d
Autor:
Robert Lodge, Nicolas Bellini, Mélanie Laporte, Syim Salahuddin, Jean-Pierre Routy, Petronela Ancuta, Cecilia T. Costiniuk, Mohammad-Ali Jenabian, Éric A. Cohen
Publikováno v:
mBio, Vol 11, Iss 5 (2020)
ABSTRACT Macrophages are a target of human immunodeficiency virus type 1 (HIV-1) and may serve as a viral reservoir during antiretroviral therapy (ART). Their susceptibility to HIV-1 infection is subject to variations from permissiveness to resistanc
Externí odkaz:
https://doaj.org/article/bf3c9c672de24376b80f6cc1733e60a9
Publikováno v:
mBio, Vol 11, Iss 2 (2020)
ABSTRACT Human immunodeficiency virus type 1 (HIV-1) establishes lifelong infections in humans, a process that relies on its ability to thwart innate and adaptive immune defenses of the host. Recently, we reported that HIV-1 infection results in a dr
Externí odkaz:
https://doaj.org/article/006b52600c4f4fdaae933574a259397e
Autor:
Robert Lodge, Jérémy A. Ferreira Barbosa, Félix Lombard-Vadnais, Julian C. Gilmore, Alexandre Deshiere, Annie Gosselin, Tomas Raul Wiche Salinas, Mariana G. Bego, Christopher Power, Jean-Pierre Routy, Petronela Ancuta, Michel J. Tremblay, Éric A. Cohen
Publikováno v:
Cell Reports, Vol 21, Iss 1, Pp 141-153 (2017)
Macrophages are heterogeneous immune cells with distinct origins, phenotypes, functions, and tissue localization. Their susceptibility to HIV-1 is subject to variations from permissiveness to resistance, owing in part to regulatory microRNAs. Here, w
Externí odkaz:
https://doaj.org/article/b79fa5ac2bb9497c9de47770d7042beb
Autor:
Alexandre Deshiere, Charles Joly-Beauparlant, Yann Breton, Michel Ouellet, Frédéric Raymond, Robert Lodge, Corinne Barat, Marc-André Roy, Jacques Corbeil, Michel J. Tremblay
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract It has been proposed that macrophages could serve as long-lived compartments for HIV-1 infection under in vivo situations because these cells are resistant to the virus-mediated cytopathic effect, produce progeny virus over extended periods
Externí odkaz:
https://doaj.org/article/ea2329ad91314c6c8c74950e07bd5937
Autor:
Robert Lodge, Julian C. Gilmore, Jérémy A. Ferreira Barbosa, Félix Lombard-Vadnais, Éric A. Cohen
Publikováno v:
Viruses, Vol 10, Iss 1, p 13 (2017)
Human immunodeficiency virus type-1 (HIV-1) infection of monocyte/macrophages is modulated by the levels of entry receptors cluster of differentiation 4 (CD4) and C-C chemokine receptor type 5 (CCR5), as well as by host antiviral restriction factors,
Externí odkaz:
https://doaj.org/article/daba3da829ab4ff281c015b3f95b118a
Autor:
Robert Lodge, Michel Ouellet, Corinne Barat, Guadalupe Andreani, Pranav Kumar, Michel J Tremblay
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32761 (2012)
Over the past decade, the number of reported human immunodeficiency virus type-1 (HIV-1)/Leishmania co-infections has risen dramatically, particularly in regions where both diseases are endemic. Although it is known that HIV-1 infection leads to an i
Externí odkaz:
https://doaj.org/article/d4170db6758d4eaf8e56e05fefe08e4a
Autor:
Pranav Kumar, Robert Lodge, Nathalie Trudel, Michel Ouellet, Marc Ouellette, Michel J Tremblay
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 4, Iss 3, p e642 (2010)
Visceral leishmaniasis has now emerged as an important opportunistic disease in patients coinfected with human immunodeficiency virus type-1 (HIV-1). Although the effectiveness of HIV-1 protease inhibitors, such as nelfinavir, in antiretroviral thera
Externí odkaz:
https://doaj.org/article/5cf93f0845184465b43da0ff36e6f2e4