Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Robert Laynes"'
Autor:
Vincenzo Cerundolo, Richard Boyd, Francesca M. Buffa, Stephen Taylor, Lars R. Olsen, Robert L. Strausberg, Qi Zhao, Robert Laynes, Lauren J. Howson, Uzi Gileadi, Dawn Shepherd, Jonathan D. Silk, Hemza Ghadbane, Elina Timosenko
In vivo and in silico analyses of IDO and SLC1A5 expression in primary mouse and human tumors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1178cf659a9e7515b420d5f3712fdc4b
https://doi.org/10.1158/0008-5472.22411224.v1
https://doi.org/10.1158/0008-5472.22411224.v1
Autor:
Vincenzo Cerundolo, Richard Boyd, Francesca M. Buffa, Stephen Taylor, Lars R. Olsen, Robert L. Strausberg, Qi Zhao, Robert Laynes, Lauren J. Howson, Uzi Gileadi, Dawn Shepherd, Jonathan D. Silk, Hemza Ghadbane, Elina Timosenko
Table S1. Oligonucleotides used for generation of CRISPR guide sequences targeting SLC1A5, ATF4 or LAT1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e5dd43e0b07c2c9f7bc0db316789b63
https://doi.org/10.1158/0008-5472.22411215.v1
https://doi.org/10.1158/0008-5472.22411215.v1
Autor:
Vincenzo Cerundolo, Richard Boyd, Francesca M. Buffa, Stephen Taylor, Lars R. Olsen, Robert L. Strausberg, Qi Zhao, Robert Laynes, Lauren J. Howson, Uzi Gileadi, Dawn Shepherd, Jonathan D. Silk, Hemza Ghadbane, Elina Timosenko
Tryptophan degradation is an immune escape strategy shared by many tumors. However, cancer cells' compensatory mechanisms remain unclear. We demonstrate here that a shortage of tryptophan caused by expression of indoleamine 2,3-dioxygenase (IDO) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::207a83018c5a9b58be993ebaa230bb4a
https://doi.org/10.1158/0008-5472.c.6508182.v1
https://doi.org/10.1158/0008-5472.c.6508182.v1
Autor:
Vincenzo Cerundolo, Richard Boyd, Francesca M. Buffa, Stephen Taylor, Lars R. Olsen, Robert L. Strausberg, Qi Zhao, Robert Laynes, Lauren J. Howson, Uzi Gileadi, Dawn Shepherd, Jonathan D. Silk, Hemza Ghadbane, Elina Timosenko
Legends for supplementary figures.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::231698403476759f1198a7ea93d3c97c
https://doi.org/10.1158/0008-5472.22411221
https://doi.org/10.1158/0008-5472.22411221
Autor:
Margret H. Ogmundsdottir, C. A. R. Boyd, Bruno Reynolds, Deborah C.I. Goberdhan, Robert Laynes
The IIS (insulin/IGF (insulin-like growth factor) signalling) cascade has an important role in regulating normal development and physiology, as evidenced by its effects in a host of major human diseases including cancer, Type 2 diabetes and neurodege
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1195dc1aac3d31d7b6c55eba9bf395a5
https://doi.org/10.1042/bst0351215
https://doi.org/10.1042/bst0351215
Autor:
C. A. Richard Boyd, Bruno Reynolds, Deborah C.I. Goberdhan, Robert Laynes, Shubana Kazi, Pietro Roversi
Publikováno v:
Biochemical Journal. 420:363-372
Mammalian CD98 heterodimeric amino acid transporters consist of a promiscuous single-pass transmembrane glycoprotein, CD98hc (CD98 heavy chain), and one of six multipass transmembrane proteins or ‘light chains’. The heterodimeric complexes of CD9
Autor:
I Karydis, S Lakhal, Jonathan D. Silk, Vincenzo Cerundolo, L Vallius, Robert Laynes, C Marcea, Boyd Car.
Publikováno v:
Journal of Immunology. 187(4)
IDO is the rate-limiting enzyme in the kynurenine pathway, catabolizing tryptophan to kynurenine. Tryptophan depletion by IDO-expressing tumors is a common mechanism of immune evasion inducing regulatory T cells and inhibiting effector T cells. Becau
Autor:
Bruno Reynolds, Pietro Roversi, Robert Laynes, Shubana Kazi, C. A. Richard Boyd, Deborah C. I. Goberdhan
Publikováno v:
Biochemical Journal; May2009, Vol. 420 Issue 3, p363-372, 10p
Publikováno v:
Reproduction. 52:401-412
Publikováno v:
Brain Research. 323:326-329
Previous work has shown a relatively high turnover of adrenaline in the mediobasal hypothalamus during the critical period (15.00-17.00 h) of the proestrous rat. We now report that this high level of adrenergic activity can be detected in the median