Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Robert L. Woodward"'
Autor:
Sahar McKeever-Abbas, Robert L. Woodward, David Whittaker, Janette H. Cherryman, Alex Crampton, Edward G. B. Eden-Rump, Martin F. Jones, Matthew Charles Evans, Ian W. Ashworth, Rebecca E. Meadows, Phillip A. Inglesby, Andrew D. Campbell, Kathryn Skilling, Jemma Clark
Publikováno v:
Organic Process Research & Development. 22:1801-1808
We developed a scalable Suzuki process for the synthesis of lanabecestat (+)-camsylate, an active pharmaceutical ingredient that was recently investigated in a Phase III clinical program for the treatment of early Alzheimer’s disease. The evolution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04f39ad1a0029d2cc9c25c1e4194005b
https://doi.org/10.1021/acs.oprd.8b00312
https://doi.org/10.1021/acs.oprd.8b00312
Publikováno v:
Organic Process Research & Development. 21:1404-1412
A new route to 2-oxopropanethioamide, a key intermediate in the synthesis of lanabecestat (AZD3293/LY3314814), is described by employing commercially available 2,2-diethoxypropionitrile as a raw material. In contrast to the previous route, this work
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82c2a187e573803fd034093f3e419955
https://doi.org/10.1021/acs.oprd.7b00170
https://doi.org/10.1021/acs.oprd.7b00170
Autor:
Robert L. Woodward, Michaela M. Castleman, Chelsea E. Meloche, Mary E. Karpen, Clare G. Carlson, William H. Yobi, Jacqueline C. Jepsen, Benjamin W. Lewis, Brooke N. Zarnosky, Paul D. Cook
Publikováno v:
Protein Sci
Many gram‐positive bacteria produce bacillithiol to aid in the maintenance of redox homeostasis and degradation of toxic compounds, including the antibiotic fosfomycin. Bacillithiol is produced via a three‐enzyme pathway that includes the action
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b6564b8e32102c68ad7c544b546ce14
https://pubmed.ncbi.nlm.nih.gov/31867856
https://pubmed.ncbi.nlm.nih.gov/31867856
Autor:
Zacharias Amara, Giancarlo Franciò, Daniel Geier, Charles M. Gordon, Robert L. Woodward, Rubén Duque, Walter Leitner, Rebecca E. Meadows, Martyn Poliakoff
Publikováno v:
Organic Process Research & Development. 20:1321-1327
The development of a continuous flow process for asymmetric hydrogenation with a heterogenized molecular catalyst in a real industrial context is reported. The key asymmetric step in the synthesis of an API (active pharmaceutical ingredient) has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a59cc081f2509402e3bb82bce21715fd
https://doi.org/10.1021/acs.oprd.6b00143
https://doi.org/10.1021/acs.oprd.6b00143
Autor:
Robert L. Woodward, Steven P. Nolan, Rebecca E. Meadows, Anthony Chartoire, Jamin L. Krinsky, Itziar Peñafiel, Carmen Claver, David J. Nelson, Martin Corpet, Julie Mayen
Publikováno v:
Organic Process Research & Development. 20:551-557
A generalized approach to the optimization and implementation of Buchwald-Hartwig reactions in flow is reported, through the combination of three key factors: a highly active palladium catalyst; a universal approach for continuous work-up and purific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::783056223ebf78fa18842fef1ef3b9c1
https://doi.org/10.1021/acs.oprd.5b00349
https://doi.org/10.1021/acs.oprd.5b00349
Autor:
Robert L. Woodward, Alexei A. Lapkin, Sebastian Falß, Polina Yaseneva, Giovanna Tomaiuolo, Antonio Perazzo, Paul Hodgson, Rebecca E. Meadows, Jacek Zakrzewski, Stefano Guido
Publikováno v:
Organic Process Research & Development. 20:558-567
A continuous Buchwald–Hartwig reaction using the bulky N-heterocyclic carbene (NHC) precatalyst [Pd(IPr*)(cin)Cl] 4 has been developed for the synthesis of a key pharmaceutical intermediate 2. Using microreactor technology, the reaction could be op
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7887591310ea8ee00e81397ca88ef5f3
https://doi.org/10.1021/acs.oprd.5b00350
https://doi.org/10.1021/acs.oprd.5b00350
Autor:
Nicholas Holmes, Rebecca E. Meadows, Robert L. Woodward, Richard A. Bourne, A. John Blacker, Geoffrey R. Akien
Publikováno v:
Reaction Chemistry & Engineering. 1:366-371
Self-optimising flow reactors combine online analysis with evolutionary feedback algorithms to rapidly achieve optimum conditions. This technique has been applied to the final bond-forming step in the synthesis of AZD9291, an irreversible epidermal g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6e9ea2d5e10a06f22025480c24b0a37
https://doi.org/10.1039/c6re00059b
https://doi.org/10.1039/c6re00059b
Online quantitative mass spectrometry for the rapid adaptive optimisation of automated flow reactors
Autor:
Robert L. Woodward, Ian R. Baxendale, Nicholas Holmes, Brian A. Taylor, Christian Stanetty, Rebecca E. Meadows, A. John Blacker, Richard A. Bourne, Geoffrey R. Akien, Robert J. D. Savage
Publikováno v:
Reaction chemistry & engineering, 2016, Vol.1(1), pp.96-100 [Peer Reviewed Journal]
An automated continuous reactor for the synthesis of organic compounds, which uses online mass spectrometry (MS) for reaction monitoring and product quantification, is presented. Quantitative and rapid MS monitoring was developed and calibrated using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c68e7a961cb71615cea9a915f051170c
https://doi.org/10.1039/c5re00083a
https://doi.org/10.1039/c5re00083a
Autor:
Robert L. Woodward, Ben McKeever-Abbas, Richard Hart, Nicholas I. Pedge, Gareth P. Howell, Adam Herring
Publikováno v:
Organic Process Research & Development. 19:537-542
Process analytical technology (PAT) was used to probe, monitor, and control the formation of process impurities during the synthesis of a pharmaceutical intermediate at 600 kg input scale. An accurate determination of end of reaction (EoR) was vital
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04cd9502635cf2a87d4ae551765a28cf
https://doi.org/10.1021/acs.oprd.5b00008
https://doi.org/10.1021/acs.oprd.5b00008