Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Robert L. Wardle"'
Autor:
Jennifer Louten,, Jeanine D. Mattson, Maria-Christina Malinao, Ying Li, Claire Emson, Felix Vega, Robert L. Wardle, Michael R. Van Scott, Robert B. Fick, Terrill K. McClanahan, Rene de Waal Malefyt, Maribel Beaumont
Publikováno v:
Biomarker Insights, Vol 2012, Iss 7, Pp 87-104 (2012)
Externí odkaz:
https://doaj.org/article/fd3fb9673f874c7d8dab8df2d3535926
Autor:
Alan D Curtis, Najla Taslim, Shaun P Reece, Elena Grebenciucova, Richard H Ray, Matthew D Rosenbaum, Robert L Wardle, Michael R Van Scott, Mark D Mannie
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110048 (2014)
Atypical models of experimental autoimmune encephalomyelitis (EAE) are advantageous in that the heterogeneity of clinical signs appears more reflective of those in multiple sclerosis (MS). Conversely, models of classical EAE feature stereotypic progr
Externí odkaz:
https://doaj.org/article/55068c2a63754589bb7a6eeb772f88df
Autor:
Andrew Peter Kennedy, Michael R. Van Scott, Ryan B. Gruber, Toshinori Hoshi, David Ritchie, Richard Woodward, Francis J. Golder, Robert L. Wardle, Courtney Ideo, Veljko Puskovic, Scott L. Dax, Santhosh M. Baby, Sean Peng, James C. Mannion, D. Euan MacIntyre
Publikováno v:
Anesthesiology. 123(5)
Background The authors describe the preclinical pharmacological properties of GAL-021, a novel peripheral chemoreceptor modulator. Methods The ventilatory effects of GAL-021 were characterized using tracheal pneumotachometry (n = 4 to 6), plethysmogr
Publikováno v:
The Journal of Physiology. 572:259-267
Acute hypoxia dilates most systemic arteries leading to increased tissue perfusion. We showed that at high stimulus conditions, porcine coronary artery was relaxed by hypoxia without a change in [Ca(2+)](i). This 'Ca(2+)-desensitizing hypoxic relaxat
Publikováno v:
The Journal of Physiology. 562:839-846
To demonstrate a Ca2+-independent component of hypoxic vasorelaxation and to investigate its mechanism, we utilized permeabilized porcine coronary arteries, in which [Ca2+] could be clamped. Arteries permeabilized with β-escin developed maximum forc
Publikováno v:
Journal of Biological Chemistry. 276:34681-34685
We investigated whether myosin light chain phosphatase activity changes during nitric oxide-induced relaxation of contracted intact carotid media and how changes in phosphatase activity mediate this relaxation. We also investigated one mechanism for
Autor:
Robert L. Wardle, Richard A. Murphy
Publikováno v:
American Journal of Physiology-Cell Physiology. 275:C1095-C1103
Exposure of porcine carotid artery smooth muscle (PCASM) to histamine was followed by a large reduction in the rate of force generation in response to 40 mM KCl. This was shown to be a manifestation of slow attainment of a steady-state myoplasmic Ca2
Autor:
Maribel Beaumont, Rene de Waal Malefyt, Jennifer Louten, Jeanine D. Mattson, Michael R. Van Scott, Robert L. Wardle, Terrill K. McClanahan, Claire Emson, Felix Vega, Robert B. Fick, Ying Li, Maria-Christina Malinao
Publikováno v:
Biomarker Insights
Biomarker Insights, Vol 7 (2012)
Biomarker Insights, Vol 2012, Iss 7, Pp 87-104 (2012)
Biomarker Insights, Vol 7 (2012)
Biomarker Insights, Vol 2012, Iss 7, Pp 87-104 (2012)
Background Biomarkers facilitate early detection of disease and measurement of therapeutic efficacy, both at clinical and experimental levels. Recent advances in analytics and disease models allow comprehensive screening for biomarkers in complex dis
Autor:
Paul A. Hoskins, Sean Peng, James C. Mannion, D. Euan MacIntyre, Francis J. Golder, Scott L. Dax, Robert L. Wardle, Santhosh M. Baby, Michael R. Van Scott, Ryan B. Gruber, Veljko Puskovic
Publikováno v:
A109. UPPER AIRWAY CONTROL, STRUCTURE AND FUNCTION.
Autor:
Robert B. Fick, Stephen Olmstead, Stuart R. Ellis, Benjamin D. Putnam, Shaun P. Reece, Robert L. Wardle, Micheal R. Van Scott, Jacqueline L. Gaddis
Publikováno v:
D33. ASTHMA PATHOGENESIS.