Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Robert L. Summers"'
Autor:
Selina Bopp, Charisse Flerida A. Pasaje, Robert L. Summers, Pamela Magistrado-Coxen, Kyra A. Schindler, Victoriano Corpas-Lopez, Tomas Yeo, Sachel Mok, Sumanta Dey, Sebastian Smick, Armiyaw S. Nasamu, Allison R. Demas, Rachel Milne, Natalie Wiedemar, Victoria Corey, Maria De Gracia Gomez-Lorenzo, Virginia Franco, Angela M. Early, Amanda K. Lukens, Danny Milner, Jeremy Furtado, Francisco-Javier Gamo, Elizabeth A. Winzeler, Sarah K. Volkman, Maëlle Duffey, Benoît Laleu, David A. Fidock, Susan Wyllie, Jacquin C. Niles, Dyann F. Wirth
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Drug resistance to current antimalarials is rising and new drugs and targets are urgently needed. Here the authors identify Plasmodium falciparum acyl-CoA synthetase 10 as a new target whose inhibition leads to a decrease in triacylglycerols.
Externí odkaz:
https://doaj.org/article/8ae40ec50bdc468aaa960a15e9ca87b3
Autor:
Sarah H. Shafik, Simon A. Cobbold, Kawthar Barkat, Sashika N. Richards, Nicole S. Lancaster, Manuel Llinás, Simon J. Hogg, Robert L. Summers, Malcolm J. McConville, Rowena E. Martin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Plasmodium falciparum chloroquine resistance transporter (PfCRT) mediates multidrug resistance, but its natural function remains unclear. Here, Shafik et al. show that PfCRT transports host-derived peptides of 4-11 residues but not other ions or meta
Externí odkaz:
https://doaj.org/article/e62a9cfeb1b74e3793184dbfb72b16f7
Autor:
Robert L. Summers, Annette Habluetzel, Stefania Lamponi, Sandra Gemma, Rowena E. Martin, Sarah H. Shafik, Stefano Federico, Reto Caldelari, Donatella Taramelli, Luca Pozzetti, Giuseppe Campiani, Sarah D'Alessandro, Stefania Butini, Simone K. Babij, Nicola Relitti, Sofia Tapanelli
Due to the surge in resistance to common therapies, malaria remains a significant concern to human health worldwide. In chloroquine (CQ)-resistant (CQ-R) strains of Plasmodium falciparum, CQ and related drugs are effluxed from the parasite’s digest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b8956bb26e1162a62798dcc944865de
http://hdl.handle.net/11365/1141531
http://hdl.handle.net/11365/1141531
Autor:
Alex Joule, Alice Patterson-Robert, Zachary R. Sailer, Michael J. Harms, Rowena E. Martin, Sarah H. Shafik, Robert L. Summers
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 9, p e1008243 (2020)
PLoS Computational Biology
PLoS Computational Biology
Understanding evolution requires detailed knowledge of genotype-phenotype maps; however, it can be a herculean task to measure every phenotype in a combinatorial map. We have developed a computational strategy to predict the missing phenotypes from a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a8101258a3c1a18ebec96e6ffceca91
https://doaj.org/article/020e794cc46b429399bb79a85a12ccc8
https://doaj.org/article/020e794cc46b429399bb79a85a12ccc8
Autor:
Marcus C. S. Lee, Edward Owen, James M. Murithi, Kerry McGowen, Beatriz Baragaña, Madeline R. Luth, Emma F. Carpenter, Jacquin C. Niles, Chris Walpole, Manu Vanaerschot, Rebecca E. K. Mandt, Sabine Ottilie, Ian H. Gilbert, Avinash S. Punekar, Charisse Flerida A. Pasaje, Krittikorn Kümpornsin, Aslı Akidil, João Pedro Pisco, Kelly Rubiano, Nimisha Mittal, David A. Fidock, Robert L. Summers, De Lin, Andy Plater, Sharon M. Shepherd, Elizabeth A. Winzeler, A. Hazel Dilmore, Andrew M. Shepherd, Amanda K. Lukens, Dyann F. Wirth, Madalyn Won, Josefine Striepen, Justin Munro, Manuel Llinás
Publikováno v:
Cell Chemical Biology. 29:191-201.e8
Summary We identify the Plasmodium falciparum acetyl-coenzyme A synthetase (PfAcAS) as a druggable target, using genetic and chemical validation. In vitro evolution of resistance with two antiplasmodial drug-like compounds (MMV019721 and MMV084978) s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80e3028ee2d6c74bf0739d4ebecac7eb
https://doi.org/10.1016/j.chembiol.2021.07.010
https://doi.org/10.1016/j.chembiol.2021.07.010
Autor:
Robert L. Summers, Yimin Huang, Pu-Ting Dong, Kai-Chih Huang, Ji-Xin Cheng, Andy J. Chen, Dyann F. Wirth, Selina Bopp, Cheng Zong
Publikováno v:
Journal of Biomedical Optics
Hemozoin, the heme detoxification end product in malaria parasites during their growth in the red blood cells (RBCs), serves as an important marker for diagnosis and treatment target of malaria disease. However, the current method for hemozoin-target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4db968e1ac0ea305bc43de14182123a5
http://europepmc.org/articles/PMC6916744
http://europepmc.org/articles/PMC6916744
Publikováno v:
Journal of Biological Chemistry. 293:13327-13337
The antimalarial activity of chemically diverse compounds, including the clinical candidate cipargamin, has been linked to the ATPase PfATP4 in the malaria-causing parasite Plasmodium falciparum The characterization of PfATP4 has been hampered by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19fcb83edcd40f4f68c6a72e05d5e643
https://doi.org/10.1074/jbc.ra118.003640
https://doi.org/10.1074/jbc.ra118.003640
Autor:
Nicole S. Lancaster, Manuel Llinás, Sarah H. Shafik, Robert L. Summers, Simon J. Hogg, Malcolm J. McConville, Kawthar Barkat, Rowena E. Martin, Simon A. Cobbold, Sashika N. Richards
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The Plasmodium falciparum chloroquine resistance transporter (PfCRT) is a key contributor to multidrug resistance and is also essential for the survival of the malaria parasite, yet its natural function remains unresolved. We identify host-derived pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78c80cce56587a46440b3acf33d9e412
https://pubmed.ncbi.nlm.nih.gov/32764664
https://pubmed.ncbi.nlm.nih.gov/32764664
Publikováno v:
The Journal of biological chemistry. 293(34)
The antimalarial activity of chemically diverse compounds, including the clinical candidate cipargamin, has been linked to the ATPase PfATP4 in the malaria-causing parasite Plasmodium falciparum. The characterization of PfATP4 has been hampered by th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4aeb4f28baf8c417db3ebaeab5007638
https://pubmed.ncbi.nlm.nih.gov/29986883
https://pubmed.ncbi.nlm.nih.gov/29986883
Autor:
Rowena E. Martin, Max Meyrath, Megan N. Nash, Wilfred D. Stein, Robert L. Summers, Sebastiano Bellanca, Michael Lanzer, Anurag Dave, Martin Dittmer, Cecilia P. Sanchez
Publikováno v:
The Journal of Biological Chemistry
Background: Mutations in the chloroquine resistance transporter (PfCRT) change the susceptibility of Plasmodium falciparum to diverse antimalarial drugs. Results: In addition to chloroquine, PfCRT transports quinine, quinidine, and verapamil, which b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc6ec9cd8b81ba3802e0bc1c7122b0c1
https://doi.org/10.1074/jbc.m114.614206
https://doi.org/10.1074/jbc.m114.614206