Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Robert L. Stolfi"'
Autor:
Daniel S. Martin, Jason C. Tsai, Jason A. Koutcher, Douglas Ballon, Robert L. Stolfi, Alan A. Alfieri, Cornelia Matei
Publikováno v:
Cancer Investigation. 15:111-120
The combination of N-(phosphonacetyl)-L-aspartate (PALA), 6-methylmercaptopurine riboside (MMPR), and 6-aminonicotinamide (6AN) has been shown to be an effective antineoplastic regimen and also to enhance the effects of other antineoplastic agents (1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f4d01fe20beb8c8a4e00c47f7f22d2d
https://doi.org/10.3109/07357909709115763
https://doi.org/10.3109/07357909709115763
Publikováno v:
Anti-Cancer Drugs. 7:100-104
A three-drug combination, PMA, consisting of (phosphonacetyl)-L-aspartic acid + 6-methylmercaptopurine riboside + 5-aminonicotinamide, preceding either 5-fluorouracil (5-FU) or adriamycin (Adr), produced tumor-regressing activity in a murine advanced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e23643ca7606b48c6e5ac04c681fbfdc
https://doi.org/10.1097/00001813-199601000-00012
https://doi.org/10.1097/00001813-199601000-00012
Publikováno v:
Biochemical Pharmacology. 50:1943-1948
DNA-damaging agents, e.g. Adriamycin ® (ADR), are reported to cause tumor regression by induction of apoptosis. A reduction in the intracellular content of ATP is part of the biochemical cascade of events that ultimately results in programmed death
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::423e7a9112d9e81ac0832c689641abac
https://doi.org/10.1016/0006-2952(95)02094-2
https://doi.org/10.1016/0006-2952(95)02094-2
Autor:
Charles W. Young, Mary L. Devitt, David Cowburn, Daniel S. Martin, Robert C. Sawyer, Robert L. Stolfi, Alice B. Kornblith, Jason A. Koutcher
Publikováno v:
Magnetic Resonance in Medicine. 19:113-123
We have used in vivo 19F NMR spectroscopy to study the metabolism of 5-fluorouracil (FUra) in tumors with and without pretreatment with methotrexate (MTX). Using the CD8F1 murine mammary tumor as an in vivo model, we observed signals from FUra, alpha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::434e9b9a65827447625a555c5551b822
https://doi.org/10.1002/mrm.1910190111
https://doi.org/10.1002/mrm.1910190111
Autor:
Daniel S. Martin, Robert L. Stolfi
Publikováno v:
Pharmacology & Therapeutics. 49:43-54
Most cytotoxic drugs used in cancer therapy do not discriminate between neoplastic and normal proliferating cells. To avoid irreversible damage to vital host tissues, such as bone marrow and intestine, drugs must be administered at dosages which usua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52cfa650cf20ca63fcbadf4e893a231f
https://doi.org/10.1016/0163-7258(91)90021-d
https://doi.org/10.1016/0163-7258(91)90021-d
Autor:
Robert L. Stolfi, Daniel S. Martin
Publikováno v:
Chemotherapy. 36:435-440
In experiments designed to investigate the biochemical basis for the diminution of the antitumor activity of 5-fluorouracil (FUra) by L-histidinol in CD8FI breast tumors, it was discovered that L-histidinol inhibits RNA and DNA synthesis in these tum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::519174b199e037507119de073b20bf5c
https://doi.org/10.1159/000238801
https://doi.org/10.1159/000238801
Autor:
G. Weippl, Mitsuo Ohkawa, H.-M. Grubbauer, Milap C. Nahata, Markus Ruhnke, Matthias Trautmann, A. Georgopoulos, A.M. Felber, Ferdin von Bredow, M Takashima, P. Dittrich, D. Lyon, Shuji Tokunaga, Kevin M. Smith, Kjetil K. Melby, Daniel S. Martin, I. Mutz, A. Graves, Dhanu S. Jackson, Robert W. Wheat, Iris Löw-Friedrich, Tone Børsum, R. Fotter, Álvaro Pascual, Klaus Borner, Hans Jürgen Dornbusch, E. Hatzopoulos, Schinichi Fujita, Lise Dannevig, José M. Aragón, P. Hohl, Robert L. Stolfi, T. Karachalios, Haruo Hisazumi, Wilhelm Schoeppe, Perea Ej, Tadayuki Nishikawa, K. Avent, Gunnar Størvold, Dwight A. Powell, G. López-López, G.P. Lyritis, R. Dill, G. Zobel, Walter Hopfenmüller, G. Cobbs
Publikováno v:
Chemotherapy. 36:I-VI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::340663599920cfa2ec38879832bb943e
https://doi.org/10.1159/000238792
https://doi.org/10.1159/000238792
Autor:
Joseph R. Colofiore, Stephen S. Sternberg, Victor E. Reuter, Daniel S. Martin, Robert L. Stolfi, Alan A. Alfieri, L. D. Nord, Jason A. Koutcher, George J. Netto
Publikováno v:
Cancer chemotherapy and pharmacology. 40(5)
The drug combination N-(phosphonacetyl)-l-aspartic acid (PALA), methylmercaptopurine riboside (MMPR) and 6-aminonicotinamide (6AN), referred to as PMA, induces regressions of advanced CD8F1 murine mammary carcinomas in vivo. We demonstrated that CD8F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4da528d6e904f05f41f714f44664183
https://pubmed.ncbi.nlm.nih.gov/9272113
https://pubmed.ncbi.nlm.nih.gov/9272113
Publikováno v:
Cancer investigation. 15(4)
Cancer cells that are sufficiently damaged by cancer chemotherapeutic agents (as well as radiotherapy) eventually die in an ordered sequential biochemical process known as apoptosis. Apoptosis is a general physiological mechanism for controlled cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b74771847805354c786a9b19cf0503aa
https://pubmed.ncbi.nlm.nih.gov/9246161
https://pubmed.ncbi.nlm.nih.gov/9246161
Publikováno v:
Anti-cancer drugs. 7(6)
Paclitaxel alone is active against the CD8F1 murine spontaneous mammary cancer, and when administered following an ATP-depleting combination of N-(phosphonacetyl)-L-aspartate (PALA) + 6-methylmercaptopurine riboside (MMPR) + 6-aminonicotinamide (6-AN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f0c4bfb57ac55713cd4855d3fb45822
https://pubmed.ncbi.nlm.nih.gov/8913434
https://pubmed.ncbi.nlm.nih.gov/8913434