Zobrazeno 1 - 10
of 189
pro vyhledávání: '"Robert L. Sinsheimer"'
Autor:
Douglas M Heithoff, William R Shimp, John K House, Yi Xie, Bart C Weimer, Robert L Sinsheimer, Michael J Mahan
Publikováno v:
PLoS Pathogens, Vol 8, Iss 4, p e1002647 (2012)
Salmonella is a principal health concern because of its endemic prevalence in food and water supplies, the rise in incidence of multi-drug resistant strains, and the emergence of new strains associated with increased disease severity. Insights into p
Externí odkaz:
https://doaj.org/article/cc458f1e428a43a7ba193b4e0e94e4f1
Autor:
Robert L. Sinsheimer
Publikováno v:
Regulation of Scientific Inquiry ISBN: 9780429304279
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff31f7e3eee3272de5d2fd9b3f541eb9
https://doi.org/10.4324/9780429304279-7
https://doi.org/10.4324/9780429304279-7
Publikováno v:
Epigenetics of Infectious Diseases ISBN: 9783319550190
Epigenetic programming of the pathogen and the host can have a marked influence on the development and progression of acute and chronic disease. Bacterial pathogenesis may be viewed as a developmental program similar to that of cell differentiation a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b971f7ca239a13a0d4c37712eab6d19
https://doi.org/10.1007/978-3-319-55021-3_5
https://doi.org/10.1007/978-3-319-55021-3_5
Autor:
Elena Y. Enioutina, Michael J. Mahan, Raymond A. Daynes, Douglas M. Heithoff, Robert L. Sinsheimer, Steven M. Julio, Golnaz Badie
Publikováno v:
Journal of Bacteriology. 189:4708-4717
Salmonella enterica serovar Typhimurium that lacks the DNA adenine methylase (Dam) ectopically expresses multiple genes that are preferentially expressed during infection, is attenuated for virulence, and confers heightened immunity in vaccinated hos
Autor:
Robert L. Sinsheimer
Publikováno v:
Bacteriophage. 5(1)
Autor:
Robert L. Sinsheimer
Publikováno v:
Journal of Biological Chemistry. 279:40247-40251
Publikováno v:
Infection and Immunity. 70:1006-1009
Yersinia pseudotuberculosis mutants that overproduce the DNA adenine methylase (Dam) are highly attenuated, confer fully protective immune responses, and secrete several Yersinia virulence proteins ( Yersinia outer proteins [Yops]) under conditions t
Publikováno v:
#N# The Lure of Bacterial Genetics
Bacterial pathogenesis may be viewed as a developmental program wherein the virulence traits observed are the summation of the relative contributions of nature versus nurture; i.e., a series of complex interactions between bacterial genes and the env
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6eedd3e68698229c0bd1f78106494fd7
https://doi.org/10.1128/9781555816810.ch19
https://doi.org/10.1128/9781555816810.ch19
Autor:
Raymond A. Daynes, Robert L. Sinsheimer, David A. Low, Douglas M. Heithoff, Elena Y. Enioutina, Michael J. Mahan
Publikováno v:
Infection and Immunity. 69:6725-6730
Salmonella isolates that lack or overproduce DNA adenine methylase (Dam) elicited a cross-protective immune response to different Salmonella serovars. The protection afforded by the Salmonella enterica serovar Typhimurium Dam vaccine was greater than
Publikováno v:
Annual Review of Genetics. 34:139-164
▪ Abstract A number of techniques have been developed to assess the expression of microbial virulence genes within the host (in vivo). These studies have shown that bacteria employ a wide variety of mechanisms to coordinately regulate the expressio