Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Robert L. Rodgers"'
Autor:
Robert L. Rodgers
Publikováno v:
Physiological Reports, Vol 10, Iss 9, Pp n/a-n/a (2022)
Abstract For at least 50 years, the prevailing view has been that the adenylate cyclase (AC)/cyclic AMP (cAMP)/protein kinase A pathway is the predominant signal mediating the hepatic glucose‐mobilizing actions of glucagon. A wealth of evidence, ho
Externí odkaz:
https://doaj.org/article/67297dd0449f4c8a94b9f89a61318d06
Autor:
Robert L. Rodgers
Publikováno v:
Am J Physiol Endocrinol Metab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9dddd1ac65e6904c7e926d4aff40a5e
https://doi.org/10.1152/ajpendo.00171.2021
https://doi.org/10.1152/ajpendo.00171.2021
Autor:
Robert L, Rodgers
Publikováno v:
Peptides. 159:170906
Effects of the metabolic hormone glucagon can be physiological or supraphysiological, based on agonist concentration and the mediating cellular signal. The threshold concentration (TC) for activating the AC/cAMP signal pathway in liver is ≥ 100 pM.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eac9447a15ab260c838ed40de4edbcbf
https://doi.org/10.1016/j.peptides.2022.170906
https://doi.org/10.1016/j.peptides.2022.170906
Autor:
Robert L. Rodgers
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 321(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e25cc709abbd1c9845e1c095a8e65025
https://pubmed.ncbi.nlm.nih.gov/34486402
https://pubmed.ncbi.nlm.nih.gov/34486402
Autor:
Robert L. Rodgers
Publikováno v:
Measurement of Cardiac Function ISBN: 9781003071853
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48d437303c962982c7f12fb7423cf325
https://doi.org/10.1201/9781003071853-2
https://doi.org/10.1201/9781003071853-2
Autor:
Robert L. Rodgers, Julie A. Harney
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 295:E155-E161
At concentrations around 10−9M or higher, glucagon increases cardiac contractility by activating adenylate cyclase/cyclic adenosine monophosphate (AC/cAMP). However, blood levels in vivo, in rats or humans, rarely exceed 10−10M. We investigated w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3979be8e6c91204d66901a23eabd41cb
https://doi.org/10.1152/ajpendo.90228.2008
https://doi.org/10.1152/ajpendo.90228.2008
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 82:927-933
We investigated whether the antiepileptic valproic acid (VPA) might interfere with oxidative metabolism in heart, as it does in liver. We administered VPA to working rat hearts perfused with radiolabeled carbohydrate and fatty acid fuels. Measurement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2cc2118d5dac725c4ed258f4d48cd3f
https://doi.org/10.1139/y04-096
https://doi.org/10.1139/y04-096
Publikováno v:
Molecular and Cellular Biochemistry. 226:97-105
Pharmacologic (millimolar) levels of carnitine have been reported to increase myocardial glucose oxidation, but whether physiologically relevant concentrations of carnitine affect cardiac metabolism is not known. We employed the isolated, perfused ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0707a7d0b9032960b06c0935245b2741
https://doi.org/10.1023/a:1012793924469
https://doi.org/10.1023/a:1012793924469
Autor:
Robert L. Rodgers
Publikováno v:
Current diabetes reviews. 8(5)
It is well established that glucagon can stimulate adipose lipolysis, myocardial contractility, and hepatic glucose output by activating a GPCR and adenylate cyclase (AC) and increasing cAMP production. It is also widely reported that activation of A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc72d9c2bae86b0563dae3482ee58462
https://pubmed.ncbi.nlm.nih.gov/22587514
https://pubmed.ncbi.nlm.nih.gov/22587514
Autor:
Arthur C. Cosmas, Frederick J. Vetter, Thomas G. Manfredi, Michael E. Dunn, Joshua N. King, Robert L. Rodgers
Publikováno v:
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology. 20(6)
Background: Glycolytic flux in the mouse heart during the progression of left ventricular hypertrophy (LVH) and mechanical dysfunction has not been described. Methods: The main objectives of this study were to characterize the effects of thoracic aor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfe9a8464e1e1583d04901f527a82f21
https://pubmed.ncbi.nlm.nih.gov/21296006
https://pubmed.ncbi.nlm.nih.gov/21296006