Zobrazeno 1 - 10 of 20 pro vyhledávání: '"Robert L. Roden"'
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Low-dose enoximone improves exercise capacity in chronic heart failure∗∗A list of the Enoximone Study Group Members and institutional affiliations is provided in the appendix
Autor: Michael R. Bristow, Lawrence Petrovich, Marcus A. DeWood, Richard J. Gorczynski, Michael B. Higginbotham, Peter S. Rahko, Thierry H. LeJemtel, Robert L. Roden, Margo M. Schleman, Brian D. Lowes, G. William Dec, Alastair D. Robertson, Mark A. Greenberg
Publikováno v: Journal of the American College of Cardiology. 36:501-508
OBJECTIVES This study was designed to evaluate the effects of low-dose enoximone on exercise capacity. BACKGROUND At higher doses the phosphodiesterase inhibitor, enoximone, has been shown to increase exercise capacity and decrease symptoms in heart
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63b8c8ee1fdc8849f11346768f67d107
https://doi.org/10.1016/s0735-1097(00)00759-2
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3
Changes in gene expression in the intact human heart. Downregulation of alpha-myosin heavy chain in hypertrophied, failing ventricular myocardium
Autor: Norbert F. Voelkel, Robert A. Quaife, Edward M. Gilbert, Darrin L. Dutcher, Alastair O. Robertson, Michael R. Bristow, Mona N. Rizeq, Wayne Minobe, Teresa J. Bohlmeyer, Bertron M. Groves, William T. Abraham, Brian D. Lowes, Robert L. Roden, David B. Badesch
Publikováno v: Journal of Clinical Investigation. 100:2315-2324
Using quantitative RT-PCR in RNA from right ventricular (RV) endomyocardial biopsies from intact nonfailing hearts, and subjects with moderate RV failure from primary pulmonary hypertension (PPH) or idiopathic dilated cardiomyopathy (IDC), we measure
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::861409224a159a0f088b64e102bf0fcc
https://doi.org/10.1172/jci119770
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4
Receptor Pharmacology of Carvedilol in the Human Heart
Autor: Robert L. Roden, Patti Larrabee, Michael R. Bristow, B. Müller-Beckmann, Wayne Minobe, J. D. Port, J. Klein, D. Handwerger, Lisa Skerl
Publikováno v: Journal of Cardiovascular Pharmacology. 19:S68-S80
The beta-blocker and vasodilator carvedilol was examined in preparations of human ventricular myocardium. Carvedilol is a high-affinity, slightly beta 1-selective competitive beta-blocking agent, with a KD for beta 1-receptors of approximately 4-5 nM
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::257aa7cdc9ed82e702bed08d69f1e0b4
https://doi.org/10.1097/00005344-199219001-00014
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5
The role of third‐generation beta‐blocking agents in chronic heart failure
Autor: Michael R. Bristow, Brian D. Lowes, Robert L. Roden, Edward M. Gilbert, Eric J. Eichhorn
Third-generation beta-blocking agents developed for the hypertension market are proving useful in the treatment of chronic heart failure (HF). These compounds share the ancillary property of vasodilation, which improves acute tolerability by unloadin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::862a721169d0d51cfbb450ee2f756be1
https://europepmc.org/articles/PMC6656140/
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6
Angiotensin-converting enzyme DD genotype in patients with primary pulmonary hypertension: increased frequency and association with preserved haemodynamics
Autor: Mary V. Raynolds, Lawrence S. Zisman, M. Benjamin Perryman, Brian D. Lowes, David B. Badesch, Alastair D. Robertson, Robert L. Roden, William T. Abraham, Michael R. Bristow, Bertron M. Groves, Norbert F. Voelkel, Kristine M. Wynne
Publikováno v: Journal of the Renin-Angiotensin-Aldosterone System, Vol 4 (2003)
Hypothesis/introduction A polymorphic marker within the angiotensin-converting enzyme (ACE) gene has been associated with circulating and tissue ACE activity and with a variety of forms of cardiovascular disease. Since angiotensin II (Ang II) causes
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b22dbe091bf72c8ed7e8f119dd36038
https://doaj.org/article/977d0f2c54a348009eb4912377b59463
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7
Myocardial-directed overexpression of the human beta(1)-adrenergic receptor in transgenic mice
Autor: Krishna Singh, Robert L. Roden, Wilson S. Colucci, Michael R. Bristow, Mary V. Raynolds, John D. Bisognano, Aldo Pende, Howard D. Weinberger, David J Port, Koji Asano, Catherine Communal, Teresa J. Bohlmeyer, Steven C. Wu, Burns C. Blaxall, Amornrate Sastravaha
Publikováno v: Journal of molecular and cellular cardiology. 32(5)
The beta(1)-adrenergic receptor (AR) is the dominant subtype in non-failing and failing myocardium. beta(1)-AR signaling, by the endogenous neurotransmitter norepinephrine, is central to the regulation of myocardial contractility. In heart failure, t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f2c6966fd58437e4dbe297440569fb5
https://pubmed.ncbi.nlm.nih.gov/10775486
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8
Increased protein kinase C activity and expression of Ca2+-sensitive isoforms in the failing human heart
Autor: Jacques L. Mizrahi, George E. Sandusky, Hani N. Sabbah, George L. King, Gianni Gromo, Todd Pickard, Robert L. Roden, Karen Mintze, Thomas B. Estridge, Michael R. Bristow, Richard A. Walsh, Guojie Song, Nancy Bowling, Rebecca L. Fouts, Chris J. Vlahos
Publikováno v: Circulation. 99(3)
Background —Increased expression of Ca 2+ -sensitive protein kinase C (PKC) isoforms may be important markers of heart failure. Our aim was to determine the relative expression of PKC-β1, -β2, and -α in failed and nonfailed myocardium. Methods a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::712c3f38306580048874b7516bea7abc
https://pubmed.ncbi.nlm.nih.gov/9918516
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9
Selective downregulation of the angiotensin II AT1-receptor subtype in failing human ventricular myocardium
Autor: Michael R. Bristow, J. David Port, Wayne Minobe, M. Benjamin Perryman, Mary V. Raynolds, Darrin L. Dutcher, Kelli D. Tremmel, Teresa J. Bohlmeyer, Koji Asano, Lawrence S. Zisman, Robert L. Roden, William T. Abraham, Erik Bush, Matthew J. Jenkin
Publikováno v: Circulation. 95(5)
Background The regulation of angiotensin II receptors and the two major subtypes (AT 1 and AT 2 ) in chronically failing human ventricular myocardium has not been previously examined. Methods and Results Angiotensin II receptors were measured by satu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aed9385d72298389b0a8cfd8ce56d1c0
https://pubmed.ncbi.nlm.nih.gov/9054834
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10
Cardiac adrenergic receptor effects of carvedilol
Autor: Darrin L. Dutcher, Michael R. Bristow, T. Yoshikawa, Robert L. Roden, Michel Bouvier, Koji Asano, P. Chidiak, J. D. Port, Wayne Minobe, Kelli D. Tremmel
Publikováno v: Scopus-Elsevier
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Carvedilol is an adrenoceptor antagonist which modulates the activity not only of beta 1 and beta 2 but also of alpha 1 adrenergic receptors present on the cell surface membrane of the human cardiac myocyte. In the heart, carvedilol has approximately
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca801a5dfbf70bf0ff05076bd1c865c8
https://pubmed.ncbi.nlm.nih.gov/8733065
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