Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Robert L. Ochs"'
Autor:
Lauren Behman, Mark Lefever, Jerry Kosmeder, Larry E. Morrison, Robert L. Ochs, Esteban Roberts, Julia Ashworth-Sharpe, James Grille, Donald Johnson, Anne Pedata, Eric May, William Day
Publikováno v:
Laboratory Investigation. 97:104-113
Multiplexed analysis of multiple biomarkers in a tissue sample requires use of reporter dyes with specific spectral properties that enable discrimination of signals. Conventional chromogens with broad absorbance spectra, widely used in immunohistoche
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70fe9ed259d484d8d066f1756326c163
https://doi.org/10.1038/labinvest.2016.115
https://doi.org/10.1038/labinvest.2016.115
Publikováno v:
Medical Imaging: Digital Pathology
Multiplex brightfield immunohistochemistry (IHC) offers the potential advantage to simultaneously analyze multiple biomarkers in order to, for example, determine T-cell numbers and phenotypes in a patient’s immune response to cancer. This paper pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::291dbb617793eff7c14b7585dffb37c7
https://doi.org/10.1117/12.2293168
https://doi.org/10.1117/12.2293168
Autor:
Anamika Basu, Luis Eduardo Coelho Andrade, Tino W. Sanchez, Marvin J. Fritzler, Leslimar Rios-Colon, Michael Mahler, Carlos A. Casiano, Robert L. Ochs
Publikováno v:
Clinical and Experimental Medicine
Antinuclear autoantibodies (ANAs) displaying the nuclear dense fine speckled immunofluorescence (DFS-IIF) pattern in HEp-2 substrates are commonly observed in clinical laboratory referrals. They target the dense fine speckled autoantigen of 70 kD (DF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1864566639c8ba5d39913d74db2ec1b3
http://europepmc.org/articles/PMC4684813
http://europepmc.org/articles/PMC4684813
Autor:
Jian Zhang, Tsu-Shuen Tsao, Hongjun Zhang, Brian D. Kelly, William Day, Nathan W. Polaske, Donald Johnson, Robert L. Ochs, Mark Lefever, Jerry Kosmeder, Michael Farrell, Joerg Bredno, Julia Ashworth-Sharpe, Esteban Roberts, Larry E. Morrison
Publikováno v:
Cancer Research. 78:1600-1600
Introduction Immunohistochemistry (IHC) is a valuable means to examine the distribution of protein expression at the subcellular level throughout human tissues while retaining morphology of the cells and tissue. Given the large and growing number of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::179e9af94491a6762df2e7f25b68c102
https://doi.org/10.1158/1538-7445.am2018-1600
https://doi.org/10.1158/1538-7445.am2018-1600
Publikováno v:
Molecular Cancer Therapeutics. 4:1605-1616
We have recently described an ex vivo chemoresponse assay for determining chemosensitivity in primary cultures of human tumors. In this study, we have extended these experiments in an effort to correlate chemoresponse data with gene expression patter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec61f3c02f97c8bb27ba3429875b6648
https://doi.org/10.1158/1535-7163.mct-04-0311
https://doi.org/10.1158/1535-7163.mct-04-0311
Autor:
John Piwowar, Alan Wells, Anuja Chattopadhyay, Paul Kornblith, Michael J. Gabrin, Lisa D. George, Robert L. Ochs, Dennis R Burholt
Publikováno v:
International Journal of Gynecological Cancer. 14:607-615
The treatment of ovarian cancer principally relies on the use of platinum and taxane chemotherapeutic agents. Short-term clinical results have been encouraging, but long-term responses remain limited. In this report, an in vitro assay system that uti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c03e5ed785e3f3a51ab2548b5e032082
https://doi.org/10.1111/j.1048-891x.2004.14408.x
https://doi.org/10.1111/j.1048-891x.2004.14408.x
Publikováno v:
Journal of Biological Chemistry. 278:38847-38859
Genetic manipulations have revealed the functions of RNA helicases in ribosomal RNA (rRNA) biogenesis in yeast. However, no report shows the role of an RNA helicase in rRNA formation in higher eukaryotes. This study reports the functional characteriz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd39d2d14c2e27658a828ad077938cf8
https://doi.org/10.1074/jbc.m302258200
https://doi.org/10.1074/jbc.m302258200
Autor:
Anna Maria Billi, Roberta Bortul, Robert L. Ochs, Marina Zweyer, Renato Bareggi, Giovanna Tabellini, Alberto M. Martelli, Lucio Cocco
Publikováno v:
Journal of Cellular Biochemistry. 81:19-31
Cell death in eukaryotes can occur by either apoptosis or necrosis. Apoptosis is characterized by well-defined nuclear changes which are thought to be the consequence of both proteolysis and DNA fragmentation. On the other hand, the nuclear modificat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6ce57c29427d51dd10d3cbc378cb0f3
https://doi.org/10.1002/jcb.1073
https://doi.org/10.1002/jcb.1073
Publikováno v:
Arthritis & Rheumatism. 44:826-837
Objective YKL-40 (human cartilage glycoprotein 39) is one of the most abundant proteins secreted by cultured chondrocytes. The objectives of the present study were to identify regulators of YKL-40 production in cartilage and chondrocytes and to map t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75d95fe9216ef33bb004ccbbeebf282e
https://doi.org/10.1002/1529-0131(200104)44:4<826::aid-anr139>3.0.co
https://doi.org/10.1002/1529-0131(200104)44:4<826::aid-anr139>3.0.co
Publikováno v:
Journal of Immunological Methods. 226:11-18
We observed an artifactual reactivity on Western blots when heparin was used as the anticoagulant in collected blood specimens. This nonspecific interaction was found to be due to immunoglobulin aggregates that bound to cellular proteins, in particul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d7f23ea8f8676a08b6e6c3518bb1211
https://doi.org/10.1016/s0022-1759(99)00043-5
https://doi.org/10.1016/s0022-1759(99)00043-5