Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Robert L. Ludwig"'
Autor:
Mylène Tajan, Marc Hennequart, Eric C. Cheung, Fabio Zani, Andreas K. Hock, Nathalie Legrave, Oliver D. K. Maddocks, Rachel A. Ridgway, Dimitris Athineos, Alejandro Suárez-Bonnet, Robert L. Ludwig, Laura Novellasdemunt, Nikolaos Angelis, Vivian S. W. Li, Georgios Vlachogiannis, Nicola Valeri, Nello Mainolfi, Vipin Suri, Adam Friedman, Mark Manfredi, Karen Blyth, Owen J. Sansom, Karen H. Vousden
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Dietary serine and glycine starvation has emerged as a potential therapy for cancer. Here, the authors show that inhibition of PHGDH, which mediates the first step in the serine synthesis pathway, improves the therapeutic efficacy of serine depletion
Externí odkaz:
https://doaj.org/article/4b3a136e97e9418588502ed7dece3071
Autor:
Allan M. Weissman, Karen H. Vousden, John A. Beutler, John H. Kenten, Chou-Chi H. Li, Pankaj Oberoi, Ilia V. Davydov, Jane P. Jensen, Shervon A. Pierre, Robert L. Ludwig, Kevin L. Lorick, Yien Che Tsai, Ren-Ming Dai, Jirouta Kitagaki, Yili Yang
The conjugation of proteins with ubiquitin plays numerous regulatory roles through both proteasomal-dependent and nonproteasomal-dependent functions. Alterations in ubiquitylation are observed in a wide range of pathologic conditions, including numer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bc1227002443a3063ad1af58535618d
https://doi.org/10.1158/0008-5472.c.6496439.v1
https://doi.org/10.1158/0008-5472.c.6496439.v1
Autor:
Allan M. Weissman, Karen H. Vousden, John A. Beutler, John H. Kenten, Chou-Chi H. Li, Pankaj Oberoi, Ilia V. Davydov, Jane P. Jensen, Shervon A. Pierre, Robert L. Ludwig, Kevin L. Lorick, Yien Che Tsai, Ren-Ming Dai, Jirouta Kitagaki, Yili Yang
Supplementary Figures 1-8 from Inhibitors of Ubiquitin-Activating Enzyme (E1), a New Class of Potential Cancer Therapeutics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bce062a4d872eee53295c21e6dfd6cce
https://doi.org/10.1158/0008-5472.22370567
https://doi.org/10.1158/0008-5472.22370567
Autor:
Vipin Suri, Mylène Tajan, Owen J. Sansom, Vivian S. W. Li, Rachel A. Ridgway, Laura Novellasdemunt, Eric C. Cheung, Robert L. Ludwig, Marc Hennequart, Nathalie Legrave, Nicola Valeri, Georgios Vlachogiannis, Fabio Zani, Andreas K. Hock, Alejandro Suárez-Bonnet, Nello Mainolfi, Karen Blyth, Mark Manfredi, Adam L. Friedman, Nikolaos Angelis, Karen H. Vousden, Oliver D. K. Maddocks, Dimitris Athineos
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
Many tumour cells show dependence on exogenous serine and dietary serine and glycine starvation can inhibit the growth of these cancers and extend survival in mice. However, numerous mechanisms promote resistance to this therapeutic approach, includi
Autor:
Patricia A.J. Muller, Robert L. Ludwig, Volker Dötsch, M H Stindt, Sebastian Kehrloesser, Karen H. Vousden
Publikováno v:
Oncogene
Many cancers express mutant p53 proteins that have lost wild-type tumor suppressor activity and, in many cases, have acquired oncogenic functions that can contribute to tumor progression. These activities of mutant p53 reflect interactions with sever
Publikováno v:
The EMBO Journal. 30:4921-4930
The p53 tumour suppressor protein is a transcription factor that prevents oncogenic progression by activating the expression of apoptosis and cell-cycle arrest genes in stressed cells. The stability of p53 is tightly regulated by ubiquitin-dependent
Publikováno v:
Genes & Development. 24:2430-2439
The ASPP (apoptosis-stimulating protein of p53) family of proteins can function in the nucleus to modulate the transcriptional activity of p53, with ASPP1 and ASPP2 contributing to the expression of apoptotic target genes. In this study, we describe
Autor:
Natalia Lukashchuk, David A. F. Gillespie, Owen J. Sansom, Karen H. Vousden, Robert L. Ludwig, Brendan Doyle, Saadia A. Karim, Anne Cromer, Joan S. Brugge, Marcin P. Iwanicki, Pauline Gosselin, Ee H. Tan, Jim C. Norman, Patrick T. Caswell, Patricia A.J. Muller
Publikováno v:
Cell. 139(7):1327-1341
Summaryp53 is a tumor suppressor protein whose function is frequently lost in cancers through missense mutations within the Tp53 gene. This results in the expression of point-mutated p53 proteins that have both lost wild-type tumor suppressor activit
Autor:
Yili Yang, Jane P. Jensen, Yien Che Tsai, Karen H. Vousden, Jirouta Kitagaki, Robert L. Ludwig, Ilia Davydov, Chou-Chi H. Li, John A. Beutler, Allan M. Weissman, Kevin L. Lorick, John H. Kenten, Pankaj Oberoi, Ren-Ming Dai, Shervon A. Pierre
Publikováno v:
Cancer Research. 67:9472-9481
The conjugation of proteins with ubiquitin plays numerous regulatory roles through both proteasomal-dependent and nonproteasomal-dependent functions. Alterations in ubiquitylation are observed in a wide range of pathologic conditions, including numer
Autor:
Alexey Kotlyarov, Matthias Gaestel, Karen H. Vousden, Hans Oliver Weber, Robert L. Ludwig, Deborah Morrison
Publikováno v:
Oncogene. 24:1965-1972
p53 stability is regulated by HDM2, a RING domain protein that acts as an E3 ligase to ubiquitinate p53 and target its degradation. Phosphorylation of HDM2 on serine 166 by AKT has been shown to enhance HDM2 activity and promote the degradation of p5