Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Robert L. Kruse"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Wilson disease (WD) is a potentially fatal genetic disorder with a broad spectrum of phenotypic presentations. Inactivation of the copper (Cu) transporter ATP7B and Cu overload in tissues, especially in the liver, are established causes of WD. Howeve
Externí odkaz:
https://doaj.org/article/0424c1b6aa3a445cb44ff1ea269abbe2
Autor:
Robert L. Kruse, Mercedes Barzi, Xavier Legras, Francis P. Pankowicz, Nika Furey, Lan Liao, Janming Xu, Beatrice Bissig-Choisat, Betty L. Slagle, Karl-Dimiter Bissig
Publikováno v:
JHEP Reports, Vol 3, Iss 2, Pp 100252- (2021)
Background & Aims: Development of new and more effective therapies against hepatitis B virus (HBV) is limited by the lack of suitable small animal models. The HBV transgenic mouse model containing an integrated overlength 1.3-mer construct has yielde
Externí odkaz:
https://doaj.org/article/3ed29fbe45da41f499709b7abe8d5061
Autor:
Robert L. Kruse
Publikováno v:
F1000Research, Vol 9 (2020)
A novel coronavirus (2019-nCoV) originating in Wuhan, China presents a potential respiratory viral pandemic to the world population. Current efforts are focused on containment and quarantine of infected individuals. Ultimately, the outbreak could be
Externí odkaz:
https://doaj.org/article/33b8fde0a6f34e978d3470caa9a491b5
Publikováno v:
Pneumonia, Vol 10, Iss 1, Pp 1-8 (2018)
Abstract Background In most cases of community-acquired pneumonia (CAP), an etiologic agent is not determined; the most common report from the microbiological evaluation of sputum cites “normal respiratory flora.” Non-diphtheria Corynebacterium s
Externí odkaz:
https://doaj.org/article/e891aced4ca34201a126de31c4796f6c
Autor:
Robert L. Kruse, Thomas Shum, Xavier Legras, Mercedes Barzi, Frank P. Pankowicz, Stephen Gottschalk, Karl-Dimiter Bissig
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 7, Iss C, Pp 32-41 (2017)
Current therapies against hepatitis B virus (HBV) do not reliably cure chronic infection, necessitating new therapeutic approaches. The T cell response can clear HBV during acute infection, and the adoptive transfer of antiviral T cells during bone m
Externí odkaz:
https://doaj.org/article/0eda57cb833d4cb99a64fad628fb7cef
Autor:
Cliona M. Rooney, Stephen Gottschalk, Leonid S. Metelitsa, Malcolm K. Brenner, Hao Liu, Paul Castillo, Robin Parihar, Daofeng Liu, Tim Sauer, Zhongzhen Yi, Kathan Parikh, Dimitrios L. Wagner, Robert L. Kruse, Haruko Tashiro, Bilal Omer, Thomas Shum
Supplementary Figure 3: C7R signaling does not change phenotypic composition of GD2-CAR T-cells during culture.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d28de38422f6720e2574e27ce887f86
https://doi.org/10.1158/2159-8290.22532024.v1
https://doi.org/10.1158/2159-8290.22532024.v1
Autor:
Cliona M. Rooney, Stephen Gottschalk, Leonid S. Metelitsa, Malcolm K. Brenner, Hao Liu, Paul Castillo, Robin Parihar, Daofeng Liu, Tim Sauer, Zhongzhen Yi, Kathan Parikh, Dimitrios L. Wagner, Robert L. Kruse, Haruko Tashiro, Bilal Omer, Thomas Shum
Supplementary Figure 6: Efficient retroviral transduction of T-cells with Î"34, C7R, GD2-CAR, and GD2-CAR.C7R constructs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9834a0d5003b2bdaa1de1ab2deeb6bfd
https://doi.org/10.1158/2159-8290.22532015.v1
https://doi.org/10.1158/2159-8290.22532015.v1
Autor:
Cliona M. Rooney, Stephen Gottschalk, Leonid S. Metelitsa, Malcolm K. Brenner, Hao Liu, Paul Castillo, Robin Parihar, Daofeng Liu, Tim Sauer, Zhongzhen Yi, Kathan Parikh, Dimitrios L. Wagner, Robert L. Kruse, Haruko Tashiro, Bilal Omer, Thomas Shum
Supplementary Figure 5: C7R does not significantly increase intracranial EphA2-CAR T-cell expansion against U373 tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c3a285c1f962f2a8f93d771d8d970de
https://doi.org/10.1158/2159-8290.22532018
https://doi.org/10.1158/2159-8290.22532018
Autor:
Cliona M. Rooney, Stephen Gottschalk, Leonid S. Metelitsa, Malcolm K. Brenner, Hao Liu, Paul Castillo, Robin Parihar, Daofeng Liu, Tim Sauer, Zhongzhen Yi, Kathan Parikh, Dimitrios L. Wagner, Robert L. Kruse, Haruko Tashiro, Bilal Omer, Thomas Shum
Supplementary Figure 1: CD34-IL7R* (C7R) is stably expressed in T-cells and enhances constitutive STAT5 activation relative to IL7R*.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27723675f24c64e613aa04c448f0f8b9
https://doi.org/10.1158/2159-8290.22532030
https://doi.org/10.1158/2159-8290.22532030
Autor:
Cliona M. Rooney, Stephen Gottschalk, Leonid S. Metelitsa, Malcolm K. Brenner, Hao Liu, Paul Castillo, Robin Parihar, Daofeng Liu, Tim Sauer, Zhongzhen Yi, Kathan Parikh, Dimitrios L. Wagner, Robert L. Kruse, Haruko Tashiro, Bilal Omer, Thomas Shum
Supplementary Figure 4: C7R prolongs survival of GD2-CAR T-cells but does not support autonomous cell expansion.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cd955be4498c36da823c31b289b7aff
https://doi.org/10.1158/2159-8290.22532021.v1
https://doi.org/10.1158/2159-8290.22532021.v1