Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Robert L. Kline"'
Transplantation of Enalapril-Treated Kidneys Confers Persistent Lowering of Arterial Pressure in SHR
Publikováno v:
Hypertension. 42:932-936
The kidney plays a critical role in regulating the level of arterial pressure and in the pathogenesis of hypertension. Important evidence has come from studies in which hypertension is generated by transplanting kidneys from genetically hypertensive
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 280:R1076-R1084
This study tested the hypotheses that renal medullary blood flow (MBF) in spontaneously hypertensive rats (SHR) has enhanced responsiveness to angiotensin (ANG) II and that long-term treatment with enalapril can correct this. MBF, measured by laser D
Publikováno v:
Clinica Chimica Acta. 401:184-186
Autor:
Stephen A. W. Dukacz, Robert L. Kline
Publikováno v:
Journal of Hypertension. 17:1345-1352
OBJECTIVE To determine the effect of short-term angiotensin converting enzyme inhibition (enalapril) or angiotensin II AT1 receptor blockade (losartan) on medullary hemodynamics in the spontaneously hypertensive rat (SHR). DESIGN Laser-Doppler flowme
Publikováno v:
American Journal of Physiology-Renal Physiology. 273:F104-F112
Long-term angiotensin-converting enzyme inhibitor treatment has been shown to have a persistent antihypertensive effect in spontaneously hypertensive rats (SHR) long after discontinuation of treatment. To test the hypothesis that this persistent effe
Autor:
Robert L. Kline, G. R. Guarasci
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 270:R469-R478
Nitric oxide has been suggested to be an essential mediator of pressure natriuresis. To investigate this hypothesis, the effect of acute or chronic inhibition of nitric oxide synthase on pressure natriuresis and renal interstitial hydrostatic pressur
Publikováno v:
The American Journal of Cardiology. 74:A20-A24
Rilmenidine binds to α 2 -adrenoceptors and imidazoline receptors in the central nervous system and the kidney. To test the hypothesis that rilmenidine would increase sodium excretion, renal function was studied in rats with innervated and denervate
Autor:
Robert L. Kline, Fan Liu
Publikováno v:
Hypertension. 24:467-473
The goal of this study was to determine how long-term treatment of spontaneously hypertensive rats with losartan affects the pressure-natriuresis curve. Rats were treated with losartan (12 to 15 mg.kg-1.d-1 in drinking water) starting at 4 to 5 weeks
Autor:
Robert L. Kline, J. van der Mark
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 266:R739-R748
Angiotensin II (ANG II; 10 or 30 ng/min iv) was infused for 7-10 days in unilaterally adrenalectomized and nephrectomized Sprague-Dawley rats drinking 1% NaCl. The acute pressure-natriuresis relationship was studied under Inactin anesthesia in volume
Publikováno v:
American journal of physiology. Regulatory, integrative and comparative physiology. 281(5)
The present study assessed the short- and long-term effect of tempol, a membrane-permeable mimetic of superoxide dismutase, on renal medullary hemodynamics in spontaneously hypertensive rats (SHR). Tempol was given in the drinking water (1 mM) for 4