Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Robert L. Hills"'
Autor:
Yuting Tang, George Ho, Yaxin Li, Meghan A Hall, Robert L Hills, Shawn C Black, Yin Liang, Keith T Demarest
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42134 (2012)
An increasing amount of evidence supports pleiotropic metabolic roles of the cannibinoid-1 receptor (CB1R) in peripheral tissues such as adipose, liver, skeletal muscle and pancreas. To further understand the metabolic consequences of specific blocka
Externí odkaz:
https://doaj.org/article/348ba50837ed4a5cad1ee006e48b46d9
Autor:
Marc D. Zack, Matthew P. Yates, Micky D. Tortorella, Melissa R. Radabaugh, Joseph W. Leone, Robert L. Hills, David W. Griggs, James T. Alston, Adam Skepner, Troii Hall, Anne-Marie Malfait, Elizabeth C. Arner, Olga V. Nemirovskiy
Publikováno v:
Arthritis & Rheumatism. 60:2704-2713
Objective Fibronectin fragments are thought to play a critical role in the initiation and progression of cartilage degradation in arthritis. In a recent study, fibronectin neoepitopes resulting from cleavage of intact fibronectin at the Ala271/Val272
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ba595df08bec6aa93b2f6f2b561a097
https://doi.org/10.1002/art.24753
https://doi.org/10.1002/art.24753
Autor:
J. Thompson, K. Chinn, S. Markosyan, Elizabeth C. Arner, Robert L. Hills, Anne-Marie Malfait, Debra M. Meyer, B.D. Jaffee, Micky D. Tortorella, N. Ghoreishi-Haack
Publikováno v:
Osteoarthritis and Cartilage. 17(5):627-635
Summary Objective To develop an in vivo model for rapid assessment of cartilage aggrecan degradation and its pharmacological modulation. Design Tumor necrosis factor-α (TNFα) was injected intra-articularly (IA) in rat knees and aggrecan degradation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e36bab467a51b3bcc83dfd02b50586d5
Autor:
Olga V. Nemirovskiy, Marc D. Zack, Aida Abujoub, Malini Viswanathan, Anne-Marie Malfait, Joseph W. Leone, Min Liu, Richard Mazzarella, Robert L. Hills, Micky D. Tortorella, Gary J. Bassill, Arumugam Muruganandam, Elizabeth C. Arner, Kam Fok, Aaron K. Sato, Daniel J. Sexton
Publikováno v:
Journal of Biological Chemistry. 282:11101-11109
ADAMTS-4 and ADAMTS-5 are aggrecanases responsible for the breakdown of cartilage aggrecan in osteoarthritis. Multiple ADAMTS-4 cleavage sites have been described in several matrix proteins including aggrecan, versican, and brevican, but no concise p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::286c94e433aa96350ac059c051ba855d
https://doi.org/10.1074/jbc.m611588200
https://doi.org/10.1074/jbc.m611588200
Autor:
Elizabeth C. Arner, Jennifer A. Gormley, Micky D. Tortorella, Kam Fok, Robert L. Hills, Anne-Marie Malfait, Lyle E. Pegg, Grace E. Munie
Publikováno v:
Archives of Biochemistry and Biophysics. 444:34-44
ADAMTS-4 (aggrecanase 1) is synthesized as a latent precursor protein that may require activation through removal of its prodomain before it can exert catalytic activity. We examined various proteinases as well as auto-activation under a wide range o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9c93751ce6d021757cd28ea06d84509
https://doi.org/10.1016/j.abb.2005.09.018
https://doi.org/10.1016/j.abb.2005.09.018
Publikováno v:
Journal of Orthopaedic Research. 23:611-617
Members of the bone morphogenetic protein (BMP) group of the TGF-beta superfamily have been shown to enhance matrix synthesis and maintain cartilage phenotype in long-term culture. These proteins have also been shown to augment cartilage repair in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e29129a0c764d85a96a0ef74a3c8343
https://doi.org/10.1016/j.orthres.2004.12.009
https://doi.org/10.1016/j.orthres.2004.12.009
Autor:
Arthur J. Wittwer, Micky D. Tortorella, Robert L. Hills, Elizabeth C. Arner, Anne-Marie Malfait, Jennifer Korte-Sarfaty, Kam Fok, Rui-Qin Liu, Alan M. Easton
Publikováno v:
Journal of Biological Chemistry. 279:17554-17561
Osteoarthritis is characterized by the loss of aggrecan and collagen from the cartilage extracellular matrix. The proteinases responsible for the breakdown of cartilage aggrecan include ADAMTS-4 (aggrecanase 1) and ADAMTS-5 (aggrecanase 2). Post-tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::630d82f6b08852f6c9deca4618cabed7
https://doi.org/10.1074/jbc.m313041200
https://doi.org/10.1074/jbc.m313041200
Autor:
Alfredo G. Tomasselli, Margaret H. Marino, Timothy E. Benson, James R. Kiefer, Huey-Sheng Shieh, Jennifer M. Williams, Joseph W. Leone, Elizabeth C. Arner, Micky D. Tortorella, Anne-Marie Malfait, Joe F. Wiese, Jeffery N. Carroll, Robert L. Hills, Karl J. Mathis
Publikováno v:
The Journal of biological chemistry. 283(3)
Aggrecanase-2 (a disintegrin and metalloproteinase with thrombospondin motifs-5 (ADAMTS-5)), a member of the ADAMTS protein family, is critically involved in arthritic diseases because of its direct role in cleaving the cartilage component aggrecan.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b14dbcacf23c170de304f5917acac697
https://pubmed.ncbi.nlm.nih.gov/17991750
https://pubmed.ncbi.nlm.nih.gov/17991750
Autor:
Arthur J. Wittwer, Micky D. Tortorella, Robert L. Hills, Elizabeth C. Arner, and Anne-Marie Malfait, Charles P. Anglin, Robert H. Keith, Grace E. Munie
Publikováno v:
Biochemistry. 46(21)
ADAMTS-4 (aggrecanase-1) is implicated in the breakdown of articular cartilage and is an attractive target for therapeutic intervention in arthritis. Cleavage of the native substrate, aggrecan, occurs through exosite interactions and peptide sequence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35468ecf5d97fa627a1c5c46139a81f8
https://pubmed.ncbi.nlm.nih.gov/17487981
https://pubmed.ncbi.nlm.nih.gov/17487981
Autor:
Tang, Yuting1 ytang69@yahoo.com, Ho, George1, Li, Yaxin1, Hall, Meghan A.1, Hills, Robert L.1, Black, Shawn C.1, Yin Liang1, Demarest, Keith T.1, Chowen, Julie A.2
Publikováno v:
PLoS ONE. Aug2012, Vol. 7 Issue 8, Special section p1-9. 9p.