Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Robert L. Herting"'
Publikováno v:
Neurology. 46:420-424
We tested the ability of d-cycloserine, a partial glycine agonist acting at the N-methyl-D-aspartate (NMDA) receptor complex, to improve implicit memory in Alzheimer patients in a parallel-group, placebo-controlled, double-blind study. One-hundred ei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bcab8c4ce3b6066dc8b77837369c60d
https://doi.org/10.1212/wnl.46.2.420
https://doi.org/10.1212/wnl.46.2.420
Autor:
Fumisuke Matsuo, Hugh C. Hendrie, Robert L. Herting, John J. Sramek, Neal R. Cutler, Ward T. Smith, T. Daniel Fakouhi
Publikováno v:
Journal of Geriatric Psychiatry and Neurology. 6:115-119
A multicenter, double-blind, placebo-controlled, parallel group study was conducted to assess the safety and efficacy of three doses of milacemide in the treatment of patients with senile dementia of the Alzheimer type of mild to moderate severity. P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2d27448e4ebd4e28046a0afbc8ec389
https://doi.org/10.1177/089198879300600210
https://doi.org/10.1177/089198879300600210
Autor:
Robert L. Herting, Janet A. Camp-Bruno
Publikováno v:
Psychopharmacology. 115(1-2)
Cognitive effects of the novel glycine prodrug milacemide (400 mg), the catecholaminergic agonist methylphenidate (20 mg), and placebo were evaluated in 48 healthy young adults. Throughout a 6-h drug treatment day, subjects repeatedly performed tests
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8669176e4aa2aaacd2635ad009b17086
https://pubmed.ncbi.nlm.nih.gov/7862911
https://pubmed.ncbi.nlm.nih.gov/7862911
Publikováno v:
European journal of pharmacology. 257(1-2)
The memory-enhancing potential of D-cycloserine (cycloserine) a partial agonist at the glycine recognition site on the NMDA receptor, was evaluated in mice using a thirst-motivated linear maze learning task. Immediate acute post-training injections (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19378708e68a465e337d5174ab6203b0
https://pubmed.ncbi.nlm.nih.gov/8082709
https://pubmed.ncbi.nlm.nih.gov/8082709
Publikováno v:
Clinical neuropharmacology. 15(2)
Prior research has shown that memory for facts and items (item memory) and memory for where one has learned these items (source memory) can be dissociated under certain conditions. In this study, we examined the effects of milacemide, a derivative of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::683915bba76c026d4ab031b2de775563
https://pubmed.ncbi.nlm.nih.gov/1591737
https://pubmed.ncbi.nlm.nih.gov/1591737
Publikováno v:
Neurology. 41(9)
Modulation of glycine concentrations in the brain influences learning and memory functions in experimental animals. We administered Milacemide, a glycine prodrug, or placebo to young and older healthy adults, who performed a word-retrieval task. Mila
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f522aa5766376c40f079c64cbb06973
https://pubmed.ncbi.nlm.nih.gov/1535694
https://pubmed.ncbi.nlm.nih.gov/1535694
Publikováno v:
Pharmacology, biochemistry, and behavior. 39(1)
The objective of this study was to evaluate the effectiveness of milacemide as a memory-enhancing drug in mice. Experiment 1 showed that forgetting of active avoidance learning produced by a 14-day training to test delay could be alleviated by milace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::349f47a751d64650652500269f3ff028
https://pubmed.ncbi.nlm.nih.gov/1833781
https://pubmed.ncbi.nlm.nih.gov/1833781
Autor:
Robert L. Herting
Publikováno v:
Annals of the New York Academy of Sciences. 640
Interest in the NMDA receptor as a key mechanism in long-term potentiation and possibly improved learning and memory has led to the development of milacemide as a prodrug for glycine, a modulator of the NMDA receptor. Trials of milacemide in doses ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd8c66031bc2dac42756e319bff00e7a
https://pubmed.ncbi.nlm.nih.gov/1837978
https://pubmed.ncbi.nlm.nih.gov/1837978
Publikováno v:
Biological Psychiatry. 37:596
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::893d16d72f33095c9345dbd963fbf296
https://doi.org/10.1016/0006-3223(95)94424-u
https://doi.org/10.1016/0006-3223(95)94424-u
Autor:
N. Dorin Ischlondsky, Robert Efron, Irving Mauer, André M. Bennett, Edwin O. Willis, Frederick L. Moolten, Roger G. Hart, Edwin T. Harper, Dwight J. Ingle, Robert L. Herting, Jack Benjamin
Publikováno v:
Perspectives in Biology and Medicine. 12:163-176
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7822df5f943f13c1f6eda8a022431b12
https://doi.org/10.1353/pbm.1968.0012
https://doi.org/10.1353/pbm.1968.0012